1,4-二(3'-[2'-二硫基吡啶]丙酸酰氨基)丁烷 | 141647-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1,4-二(3'-[2'-二硫基吡啶]丙酸酰氨基)丁烷
• 英文名称: 1,4-Bis[3-(2-pyridyldithio)propionamido]butane
• 英文别名: 3-(pyridin-2-yldisulfanyl)-N-[4-[3-(pyridin-2-yldisulfanyl)propanoylamino]butyl]propanamide
• CAS: 141647-62-3
• 化学式: C₂₀H₂₆N₄O₂S₄
• 分子量: 482.7
• InChiKey: JMUAKWNHKQBPGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  30
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  185
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26
• 危险类别码：
  R36/37/38

文献信息

• [EN] CLEAVABLE NUCLEOTIDE ANALOGS AND USES THEREOF<br/>[FR] ANALOGUES NUCLÉOTIDIQUES CLIVABLES ET LEURS UTILISATIONS
  申请人：HARVARD COLLEGE

  公开号：WO2018102554A1

  公开（公告）日：2018-06-07

  Cleavable nucleotide analogs are provided. The nucleotide analog includes a nucleotide molecule attached to a cleavable moiety wherein the cleavable moiety comprises a protective group and/or a linker attached to a fluorophore. The cleavable moiety is linked to the oxygen atom of the 3'-OH of the pentose of the nucleotide molecule. The nucleotide analogs can be used in making polynucleotide molecules using template independent polymerases. The nucleotide analogs can act as reversible terminators during DNA sequencing by synthesis. The cleavage of the cleavable moiety restores a free 3'-OH functional group allowing growth of the polynucleotide molecule. The general structures as well as proposed synthetic schemes for the nucleotide analogs are also provided.

  可切割的核苷酸类似物已提供。该核苷酸类似物包括连接到可切割基团的核苷酸分子，其中可切割基团包括保护基团和/或连接到荧光团的连接物。可切割基团连接到核苷酸分子的五碳糖的3'-OH的氧原子。这些核苷酸类似物可用于使用模板无关聚合酶制备多核苷酸分子。这些核苷酸类似物在DNA合成测序过程中可作为可逆终止子。切割可切割基团恢复自由的3'-OH官能团，从而促进多核苷酸分子的生长。还提供了核苷酸类似物的一般结构以及拟议的合成方案。
• [EN] MATERIALS AND METHODS FOR THE PREPARATION OF BACTERIAL CAPSULAR POLYSACCHARIDES<br/>[FR] MATÉRIAUX ET PROCÉDÉS POUR LA PRÉPARATION DE POLYSACCHARIDES CAPSULAIRES BACTÉRIENS
  申请人：UNIV CALIFORNIA

  公开号：WO2020163784A1

  公开（公告）日：2020-08-13

  Methods for preparing saccharide products such as bacterial capsular polysaccharides are provided. The methods include: forming a reaction mixture containing one or more bacterial capsular polysaccharide synthases, a sugar acceptor, and one or more sugar donors; and maintaining the reaction mixture under conditions sufficient to form the bacterial capsular saccharide product. Vaccine compositions containing bacterial capsular saccharide products prepared according to the methods are also described.

  提供了制备细菌胞外多糖等糖类产品的方法。这些方法包括：形成一个反应混合物，其中包含一个或多个细菌胞外多糖合成酶、一个糖受体和一个或多个糖供体；并在足以形成细菌胞外糖类产品的条件下维持反应混合物。还描述了根据这些方法制备的含有细菌胞外糖类产品的疫苗组合物。
• HYDROXYALKYL STARCH DERIVATIVES AS REACTANTS FOR COUPLING TO THIOL GROUPS
  申请人：FRESENIUS KABI DEUTSCHLAND GMBH

  公开号：US20160311934A1

  公开（公告）日：2016-10-27

  The present invention relates to a hydroxyalkyl starch (HAS) derivative of formula (I) wherein F1 is a functional group comprising the group —NR′—, with R′ being H or alkyl; L is a spacer bridging F1 and S; wherein HAS′ is the remainder of the HAS molecule, R b and R c are —[(CR 1 R 2 ) m O] n —H and are the same or different from each other; R a is —[(CR 1 R 2 ) m O] n —H with HAS′ being the remainder of the hydroxyalkyl starch molecule, or R a is HAS″ with HAS′ and HAS″ together being the remainder of the hydroxyalkyl starch molecule; R 1 and R 2 are independently hydrogen or an alkyl group having from 1 to 4 carbon atoms, m is 2 to 4, wherein R 1 and R 2 are the same or different from each other in the m groups CR 1 R 2 ; n is from 0 to 6.

  本发明涉及一种羟基烷基淀粉（HAS）衍生物，其化学式为（I），其中F1是包含基团—NR′—的功能基团，其中R′为H或烷基；L是桥接F1和S的间隔物；其中HAS′是HAS分子的剩余部分，Rband Rcare —[(CR1R2)mO]n—H，且彼此相同或不同；Ra是—[(CR1R2)mO]n—H，其中HAS′是羟基烷基淀粉分子的剩余部分，或者Ra是HAS″，其中HAS′和HAS″一起是羟基烷基淀粉分子的剩余部分；R1和R2独立地是氢或具有1至4个碳原子的烷基基团，m为2至4，其中在m个CR1R2基团中，R1和R2彼此相同或不同；n为0至6。
• Surface modification for improving biocompatibility
  申请人：The Children's Hospital of Philadelphia

  公开号：US20030044408A1

  公开（公告）日：2003-03-06

  A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal support, such as a medical device, results in a single molecular layer that can fasten various molecules, thereby minimizing any cellular inflammatory response while enhancing biocompatibility.

  一种治疗性输送系统能够高效地将生物活性分子引入哺乳动物细胞，而无需使用合成聚合物或生物聚合物涂层。对金属支撑物进行表面改性，如医疗器械，形成一个单分子层，可固定各种分子，从而最大程度地减少细胞炎症反应，同时增强生物相容性。
• COMPOSITIONS CONTAINING NUCLEIC ACID NANOPARTICLES WITH MODULAR FUNCTIONALITY
  申请人：Sixfold Bioscience Ltd.

  公开号：US20210330810A1

  公开（公告）日：2021-10-28

  The invention provides compositions containing cargo molecules attached to elements that improve the function of the cargo molecules in the body of a subject. The compositions are useful for therapeutic and diagnostic purposes. Furthermore, the invention outlines ways in which these compositions can be produced; the core molecule can be functionalized, via bioorthogonal click chemistry, in such a way as to impart modular characteristics. This functionalization simultaneously allows for loading of biologically relevant cargo and provides stabilization to the overall structure of the molecule.

  本发明提供了一种包含附着于能够改善受试者体内载荷分子功能的元素的组合物。该组合物在治疗和诊断方面具有用途。此外，本发明还概述了可生产这些组合物的方法；核心分子可以通过生物正交点击化学功能化，以赋予模块化特性。这种功能化同时允许装载生物相关载荷并为分子的整体结构提供稳定性。