1,4-亚苯基双-3-硫代氨基脲 | 1728-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,4-亚苯基双-3-硫代氨基脲
• 英文名称: 2,2'-(1,4-Phenylene)di(hydrazine-1-carbothioamide)
• 英文别名: [4-(2-carbamothioylhydrazinyl)anilino]thiourea
• CAS: 1728-67-2
• 化学式: C₈H₁₂N₆S₂
• 分子量: 256.4
• InChiKey: KVPRQAHEOYMTAP-UHFFFAOYSA-N

物化性质

• 熔点：
  205-206 °C
• 沸点：
  436.8±55.0 °C(Predicted)
• 密度：
  1.569±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  164
• 氢给体数：
  6
• 氢受体数：
  4

安全信息

• 海关编码：
  2930909090

文献信息

• HASylated polypeptides, especially HASylated erythropoietin
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：EP1398322A1

  公开（公告）日：2004-03-17

  The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS moecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).

  本发明涉及羟烷基淀粉（HAS）-多肽-共轭物（HAS-多肽），包括一个或多个 HAS 小分子，其中每个 HAS 通过碳水化合物分子或硫醚与多肽共轭，还涉及其生产方法。在一个优选的实施方案中，多肽是促红细胞生成素（EPO）。
• Method of producing hydroxyalkyl starch derivatives
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：EP1398327A1

  公开（公告）日：2004-03-17

  The present invention relates to a method of producing a hydroxyalkyl starch derivative, said hydroxyalkyl starch having a structure according to formula (I) comprising reacting hydroxyalkyl starch of formula (I) at its optionally oxidized reducing end or a hydroxyalkyl starch derivative, obtainable by reacting hydroxyalkyl starch of formula (I) at its optionally oxidized reducing end with a compound (D), said compound (D) comprising - - at least one functional group Z1 capable of being reacted with the optionally oxidized reducing end of the hydroxyalkyl starch, and - - at least one functional group W, with a compound (L) comprising at least one functional group Z1 capable of being reacted with said hydroxyalkyl starch, or at least one functional group Z2 capable of being reacted with functional group W comprised in said hydroxyalkyl starch derivative, and at least one functional group X capable of being reacted with a functional group Y of a further compound (M), wherein said functional group Y is selected from the group consisting of an aldehyd group, a keto group, a hemiacetal group, an acetal group, and a thio group. The present invention further relates to the hydroxyalkyl starch derivatives as such ans a pharmaceutical composition comprising the hydroxyalkyl starch derivatives.

  本发明涉及一种生产羟烷基淀粉衍生物的方法，所述羟烷基淀粉具有符合式 (I) 的结构 包括反应 式（I）的羟烷基淀粉在其可选的氧化还原端或 一种羟烷基淀粉衍生物，可通过使式（I）的羟烷基淀粉在其可选氧化还原端与化合物（D）反应获得，所述化合物（D）包括 - 至少一个可与羟烷基淀粉的可选氧化还原端反应的官能团 Z1，以及 - 至少一个官能团 W、 化合物 (L) 包括 至少一个可与所述羟烷基淀粉反应的官能团 Z1，或至少一个可与所述羟烷基淀粉衍生物中的官能团 W 反应的官能团 Z2，以及 至少一个能与另一种化合物（M）的官能团 Y 反应的官能团 X、 其中所述官能团 Y 选自由醛基、酮基、半缩醛基、缩醛基和硫代官能团组成的组。本发明还涉及羟烷基淀粉衍生物以及包含羟烷基淀粉衍生物的药物组合物。
• Hydroxyalkyl starch derivatives
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：EP1398328A1

  公开（公告）日：2004-03-17

  The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (1) at its reducing end which is not oxidized prior to said reaction, with a compound of formula (II)         R'-NH-R"     (II) wherein R1, R2 and R3 are independently hydrogen or a linear or branched hydroxyalkyl group, and wherein either R' or R" or R' and R" comprise at least one functional group X capable of being reacted with at least one other compound prior to or after the reaction of (I) and (II), as well as to the hydroxyalkyl starch derivative as such, obtainable by said method, and to a pharmaceutical composition comprising said hydroxyalkyl starch derivative.

  本发明涉及一种生产羟烷基淀粉衍生物的方法，该方法包括将式（1）的羟烷基淀粉 在反应前未被氧化的还原端与式 (II) 化合物反应 R'-NH-R" (II) 其中 R1、R2 和 R3 独立地为氢或直链或支链羟烷基，R'或 R "或 R' 和 R "包含至少一个官能团 X，可在 (I) 和 (II) 反应之前或之后与至少一个其它化合物反应，以及通过所述方法可获得的羟烷基淀粉衍生物和包含所述羟烷基淀粉衍生物的药物组合物。
• Hasylated polypeptides
  申请人：Conradt S. Harald

  公开号：US20060019877A1

  公开（公告）日：2006-01-26

  The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).

  本发明涉及由一个或多个 HAS 分子组成的羟烷基淀粉（HAS）-多肽-共轭物（HAS-多肽），其中每个 HAS 通过碳水化合物分子或硫醚与多肽共轭，还涉及其生产方法。在一个优选的实施方案中，多肽是促红细胞生成素（EPO）。
• Method of Producing Hydroxyalkyl Starch Derivatives
  申请人：Zander Norbert

  公开号：US20100317609A1

  公开（公告）日：2010-12-16

  The present invention relates to methods of producing hydroxyalkyl starch (HAS) derivatives having a structure according to formula (I) comprising reacting HAS of formula (I) at its optionally oxidized reducing end or a HAS derivative, obtainable by reacting HAS of formula (I) at its optionally oxidized reducing end with a compound (D) comprising at least one functional group Z 1 capable of being reacted with the optionally oxidized reducing end of the HAS and at least one functional group W, with a compound (L) comprising at least one functional group Z 1 capable of being reacted with said HAS, or at least one functional group Z 2 capable of being reacted with functional group W comprised in said HAS derivative, and at least one functional group X capable of being reacted with a functional group Y of a further compound. The present invention further relates to HAS derivatives and pharmaceutical compositions comprising them.