1,5-二甲基-6-氧杂双环[3.1.0]己烷 | 82461-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 中文名称: 1,5-二甲基-6-氧杂双环[3.1.0]己烷
• 中文别名: 三磷酸)四氢2'-叠氮-2'-脱氧腺苷5'-(
• 英文名称: 1,5-dimethyl-6-oxabicyclo[3.1.0]hexane
• 英文别名: 1,2-epoxy-1,2-dimethyl-cyclopentane；1,2-Epoxy-1,2-dimethyl-cyclopentan；1,5-Dimethyl-6-oxa-bicyclo[3.1.0]hexane
• CAS: 82461-31-2
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: UXMPPYGRAFYWRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,5-二甲基-6-氧杂双环[3.1.0]己烷 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 1,2-dimethylcyclopentanol
  参考文献：
  名称：

  Mechanism of Lithium Aluminum Hydride Reactions

  摘要：

  DOI：

  10.1021/ja01173a035
• 作为产物：
  描述：

  1,2-二甲基环戊烯 在 间氯过氧苯甲酸 作用下， 以 四氯化碳 为溶剂， 生成 1,5-二甲基-6-氧杂双环[3.1.0]己烷
  参考文献：
  名称：

  Vinyl substituent effects in the peracid oxidation of cyclopropenes

  摘要：

  DOI：

  10.1021/ja00825a014

文献信息

• STRONGLY LEWIS ACIDIC METAL-ORGANIC FRAMEWORKS FOR CONTINUOUS FLOW CATALYSIS
  申请人：The University of Chicago

  公开号：US20210053042A1

  公开（公告）日：2021-02-25

  Lewis acidic metal-organic framework (MOF) materials comprising triflate-coordinated metal nodes are described. The materials can be used as heterogenous catalysts in a wide range of organic group transformations, including Diels-Alder reactions, epoxide-ring opening reactions, Friedel-Crafts acylation reactions and alkene hydroalkoxylation reactions. The MOFs can also be prepared with metallated organic bridging ligands to provide heterogenous catalysts for tandem reactions and/or prepared as composites with support particles for use in columns of continuous flow reactor systems. Methods of preparing and using the MOF materials and their composites are also described.

  描述了包含三氟甲磺酸盐配位金属节点的Lewis酸性金属有机框架（MOF）材料。这些材料可用作广泛范围的有机基团转化中的杂质催化剂，包括Diels-Alder反应、环氧化物开环反应、Friedel-Crafts酰化反应和烯烃水解烷氧基化反应。这些MOF还可以通过金属化有机桥联配体制备，以提供串联反应的杂质催化剂和/或与支撑颗粒制备为复合材料，用于连续流反应器系统的柱中。还描述了制备和使用MOF材料及其复合材料的方法。
• Efficient and selective oxidation of methyl substituted cycloalkanes by heterogeneous methyltrioxorhenium–hydrogen peroxide systems
  作者：Gianluca Bianchini、Marcello Crucianelli、Carmen Canevali、Claudia Crestini、Franca Morazzoni、Raffaele Saladino

  DOI：10.1016/j.tet.2006.10.013

  日期：2006.12

  Polymer-supported methyltrioxorhenium (MTO) systems are efficient catalysts for the oxidative functionalisation of cyclohexane and cyclopentane derivatives with H2O2 as oxygen donor. Using poly(4-vinyl)pyridine and poly(4-vinyl)pyridine-N-oxide as MTO supports, cycloalkanol, cycloalkanediol, cycloalkanone and ω-hydroxy methyl ketone derivatives were obtained in different yields depending on the experimental

  聚合物负载的甲基三氧合hen（MTO）系统是用于以H 2 O 2为氧供体的环己烷和环戊烷衍生物的氧化功能化的有效催化剂。使用聚（4-乙烯基）吡啶和聚（4-乙烯基）吡啶-N-氧化物作为MTO载体，取决于实验条件，以不同的产率获得了环烷醇，环烷二醇，环烷酮和ω-羟基甲基酮衍生物。有趣的是，当用聚苯乙烯微囊化的MTO催化剂进行氧化时，以可接受的收率以良好的收率选择性回收环烷二聚体。所述EPR调查表明，CH的均裂3 -Re键与地层的CH 3 自由基发生在聚苯乙烯胶囊内部，表明甲基自由基可能在环烷二聚途径中发挥作用。
• NOVEL PHARMACEUTICAL
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1987827A1

  公开（公告）日：2008-11-05

  A tissue-selective androgen receptor modulator containing a compound represented by the formula wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents an optionally further substituted 4- to 10-membered ring, Ring C represents an optionally further substituted benzene ring, X1 represents an optionally substituted carbon atom, X2 represents an optionally substituted carbon atom, an oxygen atom and the like, W1 represents a nitrogen atom and the like, Y11 represents a group represented by the formula CR2R3' (wherein R2 represents a hydrogen atom, a cyano group, a nitro group and the like, and R3' represents a bond, a hydrogen atom, a cyano group, a nitro group and the like, respectively), Y21 represents a group represented by the formula CR4R5' (wherein R4 represents a hydrogen atom, a cyano group, a nitro group and the like, and R5' represents a bond, a hydrogen atom, a cyano group, a nitro group and the like, respectively) and the like, R1 represents an electron-withdrawing group, and the formula - - - represents a single bond or a double bond, or a salt thereof or a prodrug thereof.

  一种组合物，包含一种组分，该组分的结构式如下：其中，环A代表一个可选取代的5-至8环，环B代表一个可选进一步取代的4-至10环，环C代表一个可选进一步取代的苯环，X1代表一个可选取代的碳原子，X2代表一个可选取代的碳原子、氧原子等，W1代表一个氮原子等，Y11代表一个由式CR2R3'（其中，R2代表氢原子、氰基、硝基等，R3'分别代表键、氢原子、氰基、硝基等）表示的基团，Y21代表一个由式CR4R5'（其中，R4代表氢原子、氰基、硝基等，R5'分别代表键、氢原子、氰基、硝基等）表示的基团等，R1代表一个电子吸引基团，而式- - -表示单键或双键，或其盐或前药。
• Novel Pharmaceutical
  申请人：Yamaoka Masuo

  公开号：US20090042857A1

  公开（公告）日：2009-02-12

  A tissue-selective androgen receptor modulator containing a compound represented by the formula wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents an optionally further substituted 4- to 10-membered ring, Ring C represents an optionally further substituted benzene ring, X 1 represents an optionally substituted carbon atom, X 2 represents an optionally substituted carbon atom, an oxygen atom and the like, W 1 represents a nitrogen atom and the like, Y 11 represents a group represented by the formula CR 2 R 3′ (wherein R 2 represents a hydrogen atom, a cyano group, a nitro group and the like, and R 3′ represents a bond, a hydrogen atom, a cyano group, a nitro group and the like, respectively), Y 21 represents a group represented by the formula CR 4 R 5′ (wherein R 4 represents a hydrogen atom, a cyano group, a nitro group and the like, and R 5′ represents a bond, a hydrogen atom, a cyano group, a nitro group and the like, respectively) and the like, R 1 represents an electron-withdrawing group, and the formula represents a single bond or a double bond, or a salt thereof or a prodrug thereof.

  一种组合物的组成式，该组合物是一种组织选择性的雄激素受体调节剂，其中环A代表可选取代的5-至8-环，环B代表可选取代的4-至10-环，环C代表可选取代的苯环，X1代表可选取代的碳原子，X2代表可选取代的碳原子、氧原子等，W1代表氮原子等，Y11代表由式CR2R3'（其中R2代表氢原子、氰基、硝基等，R3'代表键、氢原子、氰基、硝基等，分别）表示的基团，Y21代表由式CR4R5'（其中R4代表氢原子、氰基、硝基等，R5'代表键、氢原子、氰基、硝基等，分别）表示的基团等，R1代表电子吸引基团，式表示单键或双键，或其盐或前药。
• FUSED BENZENE DERIVATIVE AND USE
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1553074B1

  公开（公告）日：2014-06-18