1,5-双(苄氧基)-3-戊酮 | 241477-36-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,5-双(苄氧基)-3-戊酮
• 英文名称: 1,5-dibenzyloxy-3-pentanone
• 英文别名: 1,5-bis(phenylmethoxy)pentan-3-one
• CAS: 241477-36-1
• 化学式: C₁₉H₂₂O₃
• 分子量: 298.382
• InChiKey: ABKANBSVZLTZJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,5-双(苄氧基)-3-戊酮 在 盐酸 、 氨 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲醇 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 24.0h， 生成 5,5-bis(2-(benzyloxy)ethyl)-2-butyl-3,5-dihydro-4H-imidazol-4-one
  参考文献：
  名称：

  [EN] DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS
  [FR] ANTAGONISTES DU RÉCEPTEUR DE L'ENDOTHÉLINE ET DE L'ANGIOTENSINE À DOUBLE ACTION

  摘要：

  The present disclosure relates generally to dual-acting angiotensin and endothelin receptor antagonists, or pharmaceutically acceptable salts, isotopically enriched analogs, stereoisomers, mixtures of stereoisomers, or prodrugs thereof, and methods of making and using the same.

  公开号：

  WO2023224963A1
• 作为产物：
  描述：

  在 sodium periodate 作用下， 以 乙醇 、 水 为溶剂， 以95%的产率得到1,5-双(苄氧基)-3-戊酮
  参考文献：
  名称：

  New mannose-derived ketones as organocatalysts for enantioselective dioxirane-mediated epoxidation of arylalkenes. Part 3: Chiral ketones from sugars

  摘要：

  New D-arabino-hexopyranosid-3-uloses were synthesized by a simple method from mannopyranoside derivatives. The common skeleton possesses a tunable alkoxy group as steric sensor on carbon 2 of the sugar. The new ketones were employed in the dioxirane-mediated epoxidation of a range of trans- and trisubstituted arylalkenes giving enantiomeric excesses from low to good (30-90%). The effect of the size of the steric sensor on the enantioselectivity was also studied. The least bulky group (methoxy group) enhanced the stereoselectivity (up to 90% ee toward triphenylethylene). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.014

文献信息

• Benzene compound and pharmaceutical use thereof
  申请人：Yoshitomi Pharmaceutical Industries, Ltd.

  公开号：US05948820A1

  公开（公告）日：1999-09-07

  A benzene compound of the formula ##STR1## wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Beh.cedilla.et's disease, uveal disease, systemic lupus erythematosus, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.

  一种苯环化合物，其化学式为##STR1## 其中每个符号如规范中定义的；其光学活性异构体或盐，含有该化合物的药物组合物，以及含有该化合物作为活性成分的免疫抑制剂。该化合物，光学活性异构体或盐具有出色的免疫抑制作用，并可用作器官或骨髓移植中发生的排斥反应的抑制剂，以及关节风湿病、特应性湿疹（皮炎）、Beh.cedilla.et病、葡萄膜疾病、系统性红斑狼疮、Sjogren综合症、多发性硬化症、重症肌无力、I型糖尿病、内分泌眼病、原发性胆汁性肝硬化、克罗恩病、肾小球肾炎、结节病、银屑病、天疱疮、再生障碍性贫血、特发性血小板减少性紫癜、过敏、多动脉炎、进行性系统性硬化、混合结缔组织病、主动脉炎综合征、多发性肌炎、皮肌炎、Wegener肉芽肿、溃疡性结肠炎、活动性慢性肝炎、自身免疫性溶血性贫血、Evans综合症、支气管哮喘和过敏性鼻炎的预防或治疗。它还可用作抗真菌剂和促进头发生长的刺激剂。
• US5948820A
  申请人：——

  公开号：US5948820A

  公开（公告）日：1999-09-07
• US6187821B1
  申请人：——

  公开号：US6187821B1

  公开（公告）日：2001-02-13
• US6372800B1
  申请人：——

  公开号：US6372800B1

  公开（公告）日：2002-04-16
• New mannose-derived ketones as organocatalysts for enantioselective dioxirane-mediated epoxidation of arylalkenes. Part 3: Chiral ketones from sugars
  作者：José M. Vega-Pérez、Ignacio Periñán、Margarita Vega-Holm、Carlos Palo-Nieto、Fernando Iglesias-Guerra

  DOI：10.1016/j.tet.2011.07.014

  日期：2011.9

  New D-arabino-hexopyranosid-3-uloses were synthesized by a simple method from mannopyranoside derivatives. The common skeleton possesses a tunable alkoxy group as steric sensor on carbon 2 of the sugar. The new ketones were employed in the dioxirane-mediated epoxidation of a range of trans- and trisubstituted arylalkenes giving enantiomeric excesses from low to good (30-90%). The effect of the size of the steric sensor on the enantioselectivity was also studied. The least bulky group (methoxy group) enhanced the stereoselectivity (up to 90% ee toward triphenylethylene). (C) 2011 Elsevier Ltd. All rights reserved.