1,6-己二胺,N,N-二乙基- | 13029-29-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,6-己二胺,N,N-二乙基-
• 英文名称: N,N-diethylhexane-1,6-diamine
• 英文别名: N,N-diethyl-1,6-hexanediamine；N,N-diethyl-hexanediyldiamine；N,N-Diaethyl-hexandiyldiamin；1,6-Hexanediamine, N,N-diethyl-；N',N'-diethylhexane-1,6-diamine
• CAS: 13029-29-3
• 化学式: C₁₀H₂₄N₂
• 分子量: 172.314
• InChiKey: TZBFEBDATQDIHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,6-己二胺,N,N-二乙基- 在 palladium on activated charcoal 盐酸 、 sodium tetrahydroborate 、 氢气 作用下， 以 甲醇 、 乙醇 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 106.0h， 生成 N,N-bis-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N',N'-diethyl-1,6-hexanediamine
  参考文献：
  名称：

  具有11-乙酰基5,11-二氢-6H-吡啶基[2,3-b] [1,4]苯并二氮杂-6-一个部分的甲基辛巴胺相关四胺的设计，合成和生物学活性：最佳结构要求对称和不对称多胺揭示了毒蕈碱受体亚型的存在。

  摘要：

  合成了四胺5-13和二胺14-17以及单胺18，并通过在分离的豚鼠左心房（M2）和回肠（M3）中进行的功能实验以及在大鼠中的结合试验评估了毒蕈碱受体亚型的生物学特性皮质（M1），心脏（M2）和上颌下腺（M3）匀浆和NG 108-15细胞（M4）。在四胺主链的末端氮上适当数量和类型的取代基提供了化合物，例如三苯丙胺（8）和地皮胺（6），它们具有不同的亲和力和选择性。雷帕曲明是一种不对称的四胺，是迄今为止可获得的最有效，最具选择性的M2毒蕈碱受体拮抗剂（pA2 = 9.75 +/- 0.02； pKi = 9.54 +/- 0.08）。然而，它无法区分M1和M4毒蕈碱受体亚型（选择性比：M2 / M3，1600-2200; M2 / M1，81; M2 / M4，41; M1 / M3，28; M4 / M3，55; M4 / M1 ，2）。Dipitramine是在同一末端氮上带有两个取代基

  DOI：

  10.1021/jm00046a021
• 作为产物：
  描述：

  6-氯-1-己醇 在 四溴化碳 、 potassium carbonate 、 三苯基膦 、 肼 作用下， 以 1,4-二氧六环 、 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 1,6-己二胺,N,N-二乙基-
  参考文献：
  名称：

  Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors

  摘要：

  Telomerase and telomere maintenance are emerging targets for the treatment of human cancers. We report here on the targeting of the telomere-telomerase complex with a series of small molecules based on an acridine platform. A series of 3,6-bis-amidoacridines with extended 9-anilino sidechains were designed and synthesised as potential telomeric G-quadruplex DNA (G4) interacting compounds. G4-stabilisation was assessed using a high-throughput FRET (fluorescence resonance energy transfer) assay and telomerase inhibition quantified by a modified TRAP (telomerase repeat amplification protocol) method. Within the series, the compounds showed significant G4-stabilising ability (DeltaT(m) values of 25-36degreesC at 1 muM concentration) and telomerase inhibition in the nanomolar region ((EC50)-E-tel values of 80-318 nM). Furthermore, a direct correlation between the FRET and TRAP assays was observed, supporting the use of the rapid screening FRET assay for early assessment of potential G4-stabilising telomerase inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.090

文献信息

• SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS
  申请人：Thede Kai

  公开号：US20120264704A1

  公开（公告）日：2012-10-18

  The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

  本申请涉及新颖的取代二氢吡唑酮衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及用于制备治疗和/或预防疾病的药物，特别是心血管和血液病以及肾脏疾病，并促进伤口愈合。
• Novel Multitarget Directed Triazinoindole Derivatives as Anti-Alzheimer Agents
  作者：Dushyant V. Patel、Nirav R. Patel、Ashish M. Kanhed、Sagar P. Patel、Anshuman Sinha、Deep D. Kansara、Annie R. Mecwan、Sarvangee B. Patel、Pragnesh N. Upadhyay、Kishan B. Patel、Dharti B. Shah、Navnit K. Prajapati、Prashant R. Murumkar、Kirti V. Patel、Mange Ram Yadav

  DOI：10.1021/acschemneuro.9b00226

  日期：2019.8.21

  multitarget-directed ligands (MTDLs) to confront the key pathological aberrations. A novel series of triazinoindole derivatives were designed and synthesized. In vitro studies revealed that all the compounds showed moderate to good anticholinesterase activity; the most active compound 23e showed an IC50 value of 0.56 ± 0.02 μM for AChE and an IC50 value of 1.17 ± 0.09 μM for BuChE. These derivatives are also

  阿尔茨海默氏病（AD）的多面性要求使用多靶标配体（MTDL）进行治疗以应对关键的病理畸变。设计并合成了一系列新颖的三嗪并吲哚衍生物。体外研究表明，所有化合物均显示出中等至良好的抗胆碱酯酶活性。活性最高的化合物23e对AChE的IC50值为0.56±0.02μM，对BuChE的IC50值为1.17±0.09μM。这些衍生物还具有强大的抗氧化活性。为了理解化合物23e的合理结合模式，进行了分子对接研究和分子动力学模拟研究，结果表明23e在AChE和BuChE的活性位点之间发生了显着的相互作用。化合物23e成功地减轻了SH-SY5Y细胞中H2O2诱导的氧化应激，并以浓度依赖的方式对SH-SY5Y细胞表现出优异的抗H2O2神经保护活性以及Aβ诱导的毒性。此外，在细胞毒性试验中，它对神经元SH-SY5Y细胞未显示任何明显的毒性。化合物23e在高达2000 mg / kg的剂量下未在大鼠中表现出任何急
• METHOD FOR CONTINUOUSLY PRODUCING ALKYLAMINO(METH)ACRYLAMIDES
  申请人：Schmitt Bardo

  公开号：US20110313195A1

  公开（公告）日：2011-12-22

  The invention relates to a process for continuously preparing N-alkyl(meth)acrylamides by reacting alkyl (meth)acrylates with high-boiling amines. A catalyst activation and specific workup technique achieve product qualities which have not been achieved to date. In addition, very high space-time yields and overall yields can be achieved.

  本发明涉及一种通过将烷基（甲基）丙烯酸酯与高沸点胺反应来连续制备N-烷基（甲基）丙烯酰胺的工艺。通过催化剂激活和特定的后处理技术，可以实现迄今为止未曾达到的产品质量。此外，还可以实现非常高的空间时间收率和总收率。
• PREPARATION OF N,N-(DI)ALKYLAMINOALKYL(METH)ACRYLAMIDE OR N,N-(DI)ALKYLAMINOALKYL (METH)ACRYLATE AND THE QUATERNARY AMMONIUM SALTS THEREOF AS FLOCCULATING AIDS AND GELLING AGENTS
  申请人：Evonik Roehm GmbH

  公开号：US20170369424A1

  公开（公告）日：2017-12-28

  N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl (meth)acrylate and/or a quaternary ammonium salt thereof are prepared with a low content of a compound of formula (IV) wherein R 5 in each case is a linear, branched or cyclic alkyl radical, an aryl radical which may also be substituted by one or more alkyl groups, the linear, cyclic or branched alkyl radical may have a length of 1-12 carbon atoms and is, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, hexyl, heptyl, octyl, isooctyl, nonyl, decyl, undecyl, dodecyl.

  制备低含量的化合物公式（IV）其中R5在每种情况下都是线性，支链或环烷基，芳基，也可以被一个或多个烷基取代，线性，环状或支链烷基长度可以为1-12个碳原子，例如甲基，乙基，丙基，异丙基，丁基，异丁基，叔丁基，戊基，己基，庚基，异辛基，壬基，癸基。制备N，N-（二）烷基氨基烷基（甲基）丙烯酰胺或N，N-（二）烷基氨基烷基（甲基）丙烯酸酯和/或其季铵盐。
• Process for the preparation of glyceraldehyde and derivatives thereof
  申请人：——

  公开号：US20010025124A1

  公开（公告）日：2001-09-27

  The invention pertains to a process for the preparation of glyceraldehyde, or an acetal or a hemiacetal thereof, characterized in that 3-butene-1,2-diol is dissolved in a lower alkanol and is subjected to ozonolysis to obtain a 3-hydroperoxy-3-alkoxy-propane-1,2-diol, which is subjected to a reductive treatment to obtain a hemiacetal of glyceraldehyde, which optionally may be converted into glyceraldehyde or an acetal or hemiacetal thereof, and to a process wherein the hemiacetal of glyceraldehyde is converted to a 3-aminopropane-1,2-diol derivative, by subjecting the hemiacetal of glyceraldehyde to a reductive treatment in the presence of ammonia or a primary or secondary amine. Preferably, the hemiacetal of glyceraldehyde is subjected to a reductive treatment in the presence of an amine with the formula R 1 R 2 NH, wherein R 1 and R 2 independently are hydrogen or an alkyl group with 1-18 carbon atoms, or R 1 and R 2 together with the nitrogen atom to which they are bonded form a 5- or 6-membered ring, to give a compound with the formula R 1 R 2 N—CH 2 —CHOH—CH 2 OH, wherein R 1 and R 2 have the previously given meanings

  本发明涉及一种制备甘油醛或其缩醛或半缩醛的方法，其特征在于将3-丁烯-1,2-二醇溶解于较低的烷基醇中，并进行臭氧化反应以获得3-羟基过氧基-3-烷氧基-丙烷-1,2-二醇，然后进行还原处理以获得甘油醛的半缩醛，该半缩醛可以选择性地转化为甘油醛或其缩醛或半缩醛。还涉及将甘油醛的半缩醛转化为3-氨基丙烷-1,2-二醇衍生物的方法，通过在氨或一级或二级胺存在下将甘油醛的半缩醛进行还原处理。优选地，在胺的存在下将甘油醛的半缩醛还原处理，其中胺的化学式为R1R2NH，其中R1和R2独立地为氢或具有1-18个碳原子的烷基，或者R1和R2与它们所连接的氮原子一起形成5或6元环，以给出化学式R1R2N-CH2-CHOH-CH2OH的化合物，其中R1和R2具有上述给定的含义。