1,8-二甲基异喹啉 | 102878-54-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 1,8-二甲基异喹啉
• 英文名称: 1,8-dimethylisoquinoline
• 英文别名: 1,8-Dimethyl-isochinolin
• CAS: 102878-54-6
• 化学式: C₁₁H₁₁N
• mdl: MFCD18448150
• 分子量: 157.215
• InChiKey: SZDWUIFPFNPTPF-UHFFFAOYSA-N

物化性质

• 熔点：
  49-51 °C
• 沸点：
  155 °C(Press: 15 Torr)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,8-二甲基异喹啉 在 sodium hydroxide 、 selenium(IV) oxide 、 氯化亚砜 、 silver(l) oxide 作用下， 反应 9.0h， 生成 8-甲基-1-异喹啉羰基氯化物
  参考文献：
  名称：

  Preparation of Optically Active 8,8’-Disubstituted 1,1’-Biisoquinoline

  摘要：

  Synthesis of 1,1'-biisoquinolines having substituents in the 8,8'-positions and their resolution by hplc on a chiral column on a preparative scale are described.

  DOI：

  10.3987/com-95-s60
• 作为产物：
  描述：

  1-甲基苯基乙酮 在 PPA 作用下， 以 甲苯 为溶剂， 反应 15.0h， 生成 1,8-二甲基异喹啉
  参考文献：
  名称：

  Preparation of Optically Active 8,8’-Disubstituted 1,1’-Biisoquinoline

  摘要：

  Synthesis of 1,1'-biisoquinolines having substituents in the 8,8'-positions and their resolution by hplc on a chiral column on a preparative scale are described.

  DOI：

  10.3987/com-95-s60

文献信息

• [EN] ANTIBACTERIAL COMPOUNDS HAVING BROAD SPECTRUM OF ACTIVITY<br/>[FR] COMPOSÉS ANTIBACTÉRIENS À LARGE SPECTRE D'ACTIVITÉ
  申请人：ACRAF

  公开号：WO2016096686A1

  公开（公告）日：2016-06-23

  The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.

  本发明涉及新型抗菌化合物，含有它们的药物组合物以及它们作为抗微生物药物的用途。
• SULTAM DERIVATIVES
  申请人：MAEKAWARA Naomi

  公开号：US20090192154A1

  公开（公告）日：2009-07-30

  A sultam derivative of Formula (1) described below having inhibitory action for aggrecanase activity is provided. The sultam derivative of Formula (1) and a salt thereof exhibit strong inhibitory action for aggrecanase activity in a living body of a mammalian animal including human, and is useful, for example, as an active ingredient of a pharmaceutical agent for preventing and/or treating various diseases caused by degradation of aggrecan.

  提供一种以下式（1）描述的磺酰胺衍生物，具有对聚集素酶活性的抑制作用。该式（1）的磺酰胺衍生物及其盐在哺乳动物包括人类的活体内表现出对聚集素酶活性的强抑制作用，并且可用作制药剂的活性成分，用于预防和/或治疗由聚集素降解引起的各种疾病。
• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20140296246A1

  公开（公告）日：2014-10-02

  This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R 1a , R 1b , R 2a , R 2b , R 3 , and X are described herein.

  本申请涉及一种化合物，它可以作为溴域含有蛋白质（包括溴域含有蛋白质4（BRD4））的抑制剂或调节剂，以及包含这种化合物的组合物和配方，以及使用和制备这种化合物的方法。该化合物包括公式（I）中所描述的R1a，R1b，R2a，R2b，R3和X的化合物。
• ORGANIC ELECTRIC FIELD LIGHT EMITTING ELEMENT AND PRODUCTION THEREFOR
  申请人：Mitsubishi Chemical Corporation

  公开号：EP1857521A1

  公开（公告）日：2007-11-21

  A composition for an organic electroluminescent device is a composition for forming an organic light emitting layer of an organic electroluminescent device by wet coating process. The composition contains a phosphorescent material, a charge transport material, and a solvent, in which the phosphorescent material and the charge transport material are each an unpolymerized organic compound, and the first oxidation potential of the phosphorescent material ED+, the first reduction potential of the phosphorescent material ED-, the first oxidation potential of the charge transporting material ET+, and the first reduction potential of the charge transporting material ET- satisfy the following condition: ET-+0.1≤ED-

  一种用于有机电致发光器件的组合物是一种用于通过湿涂层工艺形成有机电致发光器件的有机发光层的组合物。该组合物包含磷光材料、电荷传输材料和溶剂，其中磷光材料和电荷传输材料均为未聚合的有机化合物，磷光材料的第一氧化电位 ED+、磷光材料的第一还原电位 ED-、电荷传输材料的第一氧化电位 ET+、电荷传输材料的第一还原电位 ET- 满足以下条件：ET-+0.1≤ED-