1-(1,2-二溴丙基)-4-甲氧基苯 | 1201-60-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(1,2-二溴丙基)-4-甲氧基苯
• 英文名称: 1-(1,2-dibromopropyl)-4-methoxybenzene
• 英文别名: 1,2-dibromo-1-(4-methoxyphenyl)propane；1,2-Dibrom-1-(4-methoxy-phenyl)-propan；4-(1,2-dibromo-propyl)-anisole；4-(1,2-Dibrom-propyl)-anisol；Opt.-inakt. 4-Methoxy-1-(1.2-dibrom-propyl)-benzol；1¹.1²-Dibrom-4-methoxy-1-propyl-benzol；α.β-Dibrom-α-(4-methoxy-phenyl)-propan；4-Methoxy-1-(α.β-dibrom-propyl)-benzol；Methyl-[4-(1.2-dibrom-propyl)-phenyl]-aether；Anetholdibromid
• CAS: 1201-60-1
• 化学式: C₁₀H₁₂Br₂O
• 分子量: 308.013
• InChiKey: YBNDQTKOLHGZOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(1,2-二溴丙基)-4-甲氧基苯 在 1-phenyl-2-(2-pyridyl)-1,2-disodiumethane 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 以90%的产率得到茴香烯
  参考文献：
  名称：

  Reducing properties of 1,2-diaryl-1,2-disodiumethanes

  摘要：

  1,2-Diphenyl- and 1-phenyl-2-(2-pyridyl)-1,2-disodiumethane efficiently dehalogenate vic-dibromoderivatives, affording the corresponding alkenes. The reaction proceeds rapidly, under mild conditions and is tolerant of a variety of functional groups (alcohol, carboxylic acid, ester and amide). This procedure was successfully extended to similar vic-disubstituted compounds. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.12.054
• 作为产物：
  描述：

  茴香烯 在 溴 作用下， 以 四氢呋喃 为溶剂， 生成 1-(1,2-二溴丙基)-4-甲氧基苯
  参考文献：
  名称：

  Polycyanurate networks from dehydroanethole cyclotrimers: Synthesis and characterization

  摘要：

  Novel biobased trisphenols were obtained by palladium- and cobalt-catalyzed [2 + 2 + 2] cycloaddition of dehydroanethole isomers which were readily prepared from the natural product trans-anethole. The trisphenols were transformed into their corresponding tricyanate esters and thermally cured to give polycyanurate networks. Comparison of the thermal properties, from differential scanning calorimetry, thermogravimetric and oscillatory thermomechanical analyses, of the new tricyanate esters with similar commercial products is presented. A new tricyanate ester with an acceptable processing temperature that yields a polycyanurate with very high glass transition temperature and low water absorption was found. Interestingly, the low moisture absorption was found to help limit the degradation of residual cyanate ester groups during exposure to hot water, allowing for a substantial recovery in the glass transition temperature upon subsequent heating, an unusual phenomenon for polycyanurate networks. Published by Elsevier Ltd.

  DOI：

  10.1016/j.polymer.2013.10.050

文献信息

• Electrophilic Bromination of Alkenes, Alkynes, and Aromatic Amines with Potassium Bromide/Orthoperiodic Acid under Mild Conditions
  作者：Ardeshir Khazaei、Mohammad Zolfigol、Eskandar Kolvari、Nadiya Koukabi、Hamid Soltani、Fatemeh Komaki

  DOI：10.1055/s-0029-1216994

  日期：2009.11

  Bromination of alkenes, alkynes, and aromatic amines has efficiently been carried out at room temperature in short reaction times using potassium bromide/orthoperiodic acid in dichloromethane-water (1:1) to prepare the corresponding bromo compounds with excellent yields. bromination - orthoperiodic acid - alkenes - aromatic amines

  在室温下，使用溴化钾/原高碘酸在二氯甲烷-水（1：1）中，烯烃，炔烃和芳族胺的溴化反应已在室温下短时间内有效地进行，从而以高收率制备了相应的溴代化合物。 溴化-正高碘酸-烯烃-芳香胺
• Electrophilic Bromination of Alkenes, Alkynes, and Aromatic Amines with Iodic Acid/Potassium Bromide Under Mild Conditions
  作者：Ardeshir Khazaei、Mohammad Ali Zolfigol、Eskandar Kolvari、Nadiya Koukabi、Hamid Soltani、Leyla Sharaf Bayani

  DOI：10.1080/00397910903349992

  日期：2010.8.31

  Bromination of alkenes, alkynes, and aromatic amines has efficiently been carried out at room temperature in short reaction times using HIO3/KBr in CH2Cl2/H2O (1:1) to prepare corresponding brominated compounds in excellent yields.

  使用 HIO3/KBr 的 CH2Cl2/H2O (1:1) 溶液，可以在室温下在短时间内有效地进行烯烃、炔烃和芳香胺的溴化反应，以优异的产率制备相应的溴化化合物。
• Samarium Triflate-Catalyzed Halogen-Promoted Friedel−Crafts Alkylation with Alkenes
  作者：Saumen Hajra、Biswajit Maji、Sukanta Bar

  DOI：10.1021/ol070813t

  日期：2007.7.1

  A versatile and efficient halogen-promoted highly regio- and stereoselective Friedel-Crafts (F-C) alkylation with alkenes has been developed with use of easily available and inexpensive NBS or I2 as the efficient halogen sources. Lewis acids, in particular metal triflates, are found to be effective catalysts for this halogen-promoted F-C alkylation. Among these, Sm(OTf)3 was the best catalyst. Electron-rich

  通过使用容易获得且便宜的NBS或I2作为有效的卤素源，开发了一种通用且有效的卤素促进的高度烯烃和立体选择性的Friedel-Crafts（FC）烷基化烯烃。发现路易斯酸，特别是金属三氟甲磺酸酯，对于这种卤素促进的FC烷基化是有效的催化剂。其中，Sm（OTf）3是最好的催化剂。富含电子的芳烃与各种烯烃（包括α，β-不饱和羰基化合物）顺利进行FC烷基化。
• <i>cis</i>-Dioxomolybdenum(VI) complexes with unsymmetric linear tetradentate ligands: syntheses, structures and bromoperoxidase activities
  作者：Sathish Kumar Kurapati、Samudranil Pal

  DOI：10.1002/aoc.3403

  日期：2016.3

  chain structure via intermolecular NH⋅⋅⋅O hydrogen bonding interactions. In cyclic voltammograms, the diamagnetic complexes display an irreversible metal‐centred reduction in the potential range −0.73 to −0.88 V (vs Ag/AgCl). The physicochemical data are consistent with a very similar gross molecular structure for all of 1, 2, 3, 4, 5. All the complexes exhibit decent bromoperoxidase activities and

  [MoO 2（乙酰丙酮酸酯）2 ]，2-（（（2-（2-羟乙基氨基）乙基氨基）甲基）-4- R-苯酚的反应（H 2 L n，n  = 1-5，R  = H，Me， OME，Cl和Br，分别地）和KOH中1：1：在甲醇2摩尔比，得到一系列具有通式配合物的顺式- [的MoO 2（L ñ）]（1，2，3，4，5）收率为81–86％。使用元素分析，光谱法（红外，紫外可见和1 H NMR，13C NMR和13 C-DEPT NMR）和电化学测量。的分子结构1，2，3，4已经使用的单晶X-射线晶体学测定。在每一个1，2，3，4，所述ONNO供体6,5,5元稠合螯合环形成（L Ñ）2-和两个相互顺氧代基团组装一扭曲的八面体Ñ 2 ö 4配位球周围金属中心。在晶格中，每个1，2，3，4种形式的一维无限链结构通过分子间Ñ  H⋅⋅⋅O氢键相互作用。在循环伏安图中，抗磁性配合物在-0.73至-0.88 V（vs
• A new and highly effective organometallic approach to 1,2-dehalogenations and related reactions
  作者：Ugo Azzena、Mario Pittalis、Giovanna Dettori、Luisa Pisano、Emanuela Azara

  DOI：10.1016/j.jorganchem.2007.05.039

  日期：2007.8

  We investigated the reductive elimination of several functionalized and non-functionalized vic-dibromides with 1,2-diphenyl-, 1, 1,2,2-tetraphenyl- and l-phenyl-2-(2-pyridyl)-1,2-disodioethane. The reaction, involving some of the less expensive organic and inorganic reagents, proceeds under mild conditions, and is tolerant of a variety of functional groups. Extension of this procedure to similar 1,2-disubstituted compounds was also investigated. Reductive eliminations run on stereochernical probe compounds strongly suggest that this reaction proceeds via a "single electron" reductive elimination reaction pathway. (c) 2007 Elsevier B.V. All rights reserved.