1-(2-O,3-O,5-O-三乙酰基-beta-D-阿拉伯呋喃糖基)-2,4(1H,3H)-嘧啶二酮 | 14057-18-2

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 中文名称: 1-(2-O,3-O,5-O-三乙酰基-beta-D-阿拉伯呋喃糖基)-2,4(1H,3H)-嘧啶二酮
• 英文名称: 2',3',5'-Triacetyluridine
• 英文别名: [3,4-diacetyloxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate
• CAS: 14057-18-2
• 化学式: C₁₅H₁₈N₂O₉
• mdl: MFCD00023795
• 分子量: 370.31
• InChiKey: AUFUWRKPQLGTGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE
  申请人：Tufts University

  公开号：US20180085386A1

  公开（公告）日：2018-03-29

  This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to compounds, such as agonists, of P 2 Y 6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma and inflammatory conditions.

  该披露涉及尿苷核苷衍生物，包括含有这些核苷衍生物的治疗有效量的组合物，以及使用这些核苷衍生物或组合物治疗对P2Y6受体的化合物（如激动剂）具有响应的疾病的方法，例如神经元疾病，包括神经退行性疾病（如阿尔茨海默病、帕金森病）和创伤性中枢神经系统损伤、疼痛、唐氏综合征（DS）、青光眼和炎症性疾病。
• Uridine nucleoside derivatives, compositions and methods of use
  申请人：TUFTS UNIVERSITY

  公开号：US10544183B2

  公开（公告）日：2020-01-28

  This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma and inflammatory conditions.

  本公开涉及尿苷核苷衍生物、包含治疗有效量的这些核苷衍生物的组合物以及使用这些核苷衍生物或组合物治疗对P2Y6受体的配体（如激动剂）有反应的疾病的方法，例如神经元疾病，包括神经退行性疾病（如阿尔茨海默病、帕金森病）和创伤性中枢神经系统损伤、疼痛、唐氏综合征（DS）、青光眼和炎症。
• Uridine diphosphate derivatives, prodrugs, compositions and uses thereof
  申请人：TUFTS UNIVERSITY

  公开号：US10632138B2

  公开（公告）日：2020-04-28

  This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs for treating various disorders including, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions, e.g., psoriasis and rheumatoid arthritis.

  本公开涉及尿苷二磷酸（UDP）衍生物、其盐和/或原药在治疗炎症（如银屑病）和青光眼方面的用途，涉及UDP衍生物的原药、包含治疗有效量的这些UDP衍生物原药的组合物以及使用这些原药治疗各种疾病的方法，这些疾病包括，如神经元疾病，包括神经退行性疾病（如阿尔茨海默病、帕金森病）和创伤性中枢神经系统损伤、疼痛、唐氏综合征（DS）、青光眼和炎症，如牛皮癣和类风湿性关节炎。
• Uridine diphosphate derivatives, compositions and methods for treating neurodegenerative disorders
  申请人：Tufts University

  公开号：US11072627B2

  公开（公告）日：2021-07-27

  This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease) and traumatic CNS injury, as well as pain.

  本公开涉及尿苷二磷酸 (UDP) 衍生物、包含治疗有效量的这些 UDP 衍生物的组合物以及使用这些衍生物或组合物治疗对 P2Y6 受体的配体（如激动剂）有反应的疾病（如神经元疾病，包括神经退行性疾病（如阿尔茨海默病）和创伤性中枢神经系统损伤）以及疼痛的方法。
• URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
  申请人：Tufts University

  公开号：EP2760858B1

  公开（公告）日：2018-08-08