(2R,4R)-5-hydroxy-4-(hydroxymethyl)-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-10-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (2R,4R)-5-hydroxy-4-(hydroxymethyl)-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-10-one
• 化学式: C₉H₁₀N₂O₅
• 分子量: 226.19
• InChiKey: UUGITDASWNOAGG-AYZDMWBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  91.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• EXTRAHEPATIC DELIVERY
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20220125823A1

  公开（公告）日：2022-04-28

  The invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs at one or more internal positions on at least one strand, optionally via a linker or carrier.

  本发明涉及一种基因沉默方法，包括向细胞或需要治疗的受体中给予脂溶性基团偶联的双链iRNA，在至少一条链的一个或多个内部位置上给予治疗有效量，可选地通过连接剂或载体给予。
• Nucleic Acid Labeling Compounds
  申请人：McGall Glenn

  公开号：US20110082289A1

  公开（公告）日：2011-04-07

  Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
• Nucleic Acid Labelling Compounds
  申请人：McGall Glenn

  公开号：US20120053336A1

  公开（公告）日：2012-03-01

  Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
• Novel 2'/3'/5'-(R/S)-Serinyl Functionalized Oligonucleotides
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US20170044527A1

  公开（公告）日：2017-02-16

  The present invention provides novel chiral serinyl functionalized tethered oligunucleotides i.e. R/S serinyl functionalized tethered oligonucleotides and the process of preparation thereof. Specifically, the present invention provides a modified nucleoside unit containing the R/S serinyl derivative at 2′ of the sugar unit which is introduced in a nucleotide sequence. Also, capping of the oligonucleotides with abasic serinyl derivative to render the nuclease stability to the oligonucleotiedds is also disclosed. The chiral serinyl functionalized tethered oligonucleotides, 2′-O-[R/S-( 2 -amino- 3 -methoxy)propyl] nucleic acids with both ′3- and 5′-ends capped with two units of abasic serine have antisense activity against the miRNA.
• Chemically Ligated RNAs for CRISPR/Cas9-lgRNA Complexes as Antiviral Therapeutic Agents
  申请人：Dr. Minghong Zhong

  公开号：US20210222165A1

  公开（公告）日：2021-07-22

  Provided herein are chemically ligated guide RNA oligonucleotides (lgRNA) which comprise two functional RNA modules (crgRNA and tracrgRNA) joined by non-nucleotide chemical linkers (nNt-linker), their complexes with CRISPR-Cas9, and cells comprising lgRNAs, preparation methods of Cas9-1gRNA complexes, and their uses for prevention and treatments of viral infections in humans. Also disclosed are processes and methods for preparation of these compounds.