3-(hydroxymethyl)-6-[N-hydroxyiminomethyl]-1,2-dithiin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二噻英
• 英文名称: 3-(hydroxymethyl)-6-[N-hydroxyiminomethyl]-1,2-dithiin
• 英文别名: [6-[(Z)-hydroxyiminomethyl]dithiin-3-yl]methanol
• 化学式: C₆H₇NO₂S₂
• 分子量: 189.259
• InChiKey: SNXRBEYXVIJKOT-CLTKARDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-[(tert-Butyldimethylsilyloxy)methyl]-6-(N-hydroxyiminomethyl)-1,2-dithiin 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 以289 mg (1.53 mmol, 77%)的产率得到3-(hydroxymethyl)-6-[N-hydroxyiminomethyl]-1,2-dithiin
  参考文献：
  名称：

  1,2-dithiins having antifungal activity

  摘要：

  描述了作为抗真菌或抗感染剂有用的新型1,2-二硫杂环丙烷化合物，以及其作为此类化合物使用的方法。这些1,2-二硫杂环丙烷化合物在治疗感染方面特别有效，特别是那些由白念珠菌、新生隐球菌、烟曲霉菌、克鲁西白念珠菌、副假丝酵母菌、热带念珠菌、红色毛癣菌、表皮癣属、白色念珠菌属、丝孢子菌属、皮孢子属、丝孢丝原虫属、球孢子菌属、组织胞浆菌属、疱疹病毒、流感病毒、巨细胞病毒、人类免疫缺陷病毒、逆转录病毒、腺病毒、乳头状瘤病毒、副病毒、阿热病毒、布尼病毒、冠状病毒、副粘病毒、小核病毒、狂犬病毒、轮状病毒、肝炎病毒、金黄色葡萄球菌、嗜肠球菌、大肠杆菌、铜绿假单胞菌、空气肠杆菌、肺炎克雷伯菌、表皮葡萄球菌、黄单胞菌、不动杆菌、空气肠杆菌、沙雷氏菌、李斯特菌、单核细胞增多症链球菌、化脓性链球菌、肺炎链球菌、绿链球菌、流感嗜血杆菌、美丽变形杆菌、变形杆菌和脆弱拟杆菌引起的感染特别有效。

  公开号：

  US05580897A1

文献信息

• US5580897A
  申请人：——

  公开号：US5580897A

  公开（公告）日：1996-12-03
• [EN] PREPARATION OF SYMMETRICAL AND UNSYMMETRICAL DITHIIN COMPOUNDS<br/>[FR] PREPARATION DE COMPOSES DE DITHIINE SYMETRIQUES ET ASYMETRIQUES
  申请人：——

  公开号：WO1995024404A1

  公开（公告）日：1995-09-14

  [EN] Novel 1,2-dithiin compounds useful as antifungal or anti-infective agents, as well as methods for their use as such, are described. The 1,2-dithiin compounds are particularly effective in treating infections, especially those caused by Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Candida krusei, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Epidermophyton species, Microsporum species, Sporothrix species, Blastomyces dermatitidis, Coccidiodes immiitis, Histoplasma capsulatum, Herpes virus, Influenza virus, Cytomegalovirus, human immunodeficiency virus, retrovirus, Adenovirus, Papillomavirus, Paravirus, Arenavirus, Bunyavirus, Coronavirus, Paramyxovirus, Picornavirus, Rhabdlovirus, Togavirus, Hepadnavirus, Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella pneumoniae, Staphylococcus epidermis, Zanthomonus maltrophilia, Acinetobacter, Enterobacter cloacae, Serratia marscens, Listeria, Monocytogenes, Enterococcus faecalis, Streptococcus pyogenes; Straptococcus pneumonia, Viridans streptococci, Haemophilus influenzae, Proteus mirabilis, proteus vulgaris and Bacterioides fragilis.
  [FR] Nouveaux-composés de la 1,2-dithiine utiles comme agents antifongiques ou comme agents anti-infectieux et leurs méthodes d'utilisation. Les composés de la 1,2-dithiine sont particulièrement efficaces pour traiter des infections, en particulier celles causées par Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Candida krusei, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, les espèces du genres Epidermophyton, les espèces du genre Microsporum, les espèces du genre Sporothrix, Blastomyces dermatitidis, Coccidiodes immiitis, Histoplasma capsulatum, Herpes virus, virus de la grippe, Cytomegalovirus, virus de l'immunodéficience humaine, retrovirus, Adenovirus, Papillomavirus, Paravirus, Arenavirus, Bunyavirus, Coronavirus, Paramyxovirus, Picornavirus, Rhabdlovirus, Togavirus, Hepadnavirus, Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella pneumoniae, Staphylococcus epidermis, Zanthomonus maltrophilia, Acinetobacter, Enterobacter cloacae, Serratia marscens, Listeria, Monocytogenes, Enterococcus faecalis, Streptococcus pyogenes; Straptococcus pneumonia, Viridans streptococci, Haemophilus influenzae, Proteus mirabilis, proteus vulgaris et Bacterioides fragilis.
• 1,2-dithiins having antifungal activity
  申请人：Shaman Pharmaceuticals, Inc.

  公开号：US05580897A1

  公开（公告）日：1996-12-03

  Novel 1,2-dithiin compounds useful as antifungal or anti-infective agents, as well as methods for their use as such, are described. The 1,2-dithiin compounds are particularly effective in treating infections, especially those caused by Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Candida krusei, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Epidermophyton species, Microsporum species, Sporothrix species, Blastomyces dermatitidis, Coccidiodes immiitis, Histoplasma capsulatum, Herpes virus, Influenza virus, Cytomegalovirus, human immunodeficiency virus, retrovirus, Adenovirus, Papillomavirus, Paravirus, Arenavirus, Bunyavirus, Coronavirus, Paramyxovirus, Picornavirus, Rhabdlovirus, Togavirus, Hepadnavirus, Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella pneumoniae, Staphylococcus epidermis, Zanthomonus maltrophilia, Acinetobacter, Enterobacter cloacae, Serratia marscens, Listeria, Monocytogenes, Enterococcus faecalis, Streptococcus pyogenes; Straptococcus pneumonia, Viridans streptococci, Haemophilus influenzae, Proteus mirabilis, proteus vulgaris and Bacterioides fragilis.

  描述了作为抗真菌或抗感染剂有用的新型1,2-二硫杂环丙烷化合物，以及其作为此类化合物使用的方法。这些1,2-二硫杂环丙烷化合物在治疗感染方面特别有效，特别是那些由白念珠菌、新生隐球菌、烟曲霉菌、克鲁西白念珠菌、副假丝酵母菌、热带念珠菌、红色毛癣菌、表皮癣属、白色念珠菌属、丝孢子菌属、皮孢子属、丝孢丝原虫属、球孢子菌属、组织胞浆菌属、疱疹病毒、流感病毒、巨细胞病毒、人类免疫缺陷病毒、逆转录病毒、腺病毒、乳头状瘤病毒、副病毒、阿热病毒、布尼病毒、冠状病毒、副粘病毒、小核病毒、狂犬病毒、轮状病毒、肝炎病毒、金黄色葡萄球菌、嗜肠球菌、大肠杆菌、铜绿假单胞菌、空气肠杆菌、肺炎克雷伯菌、表皮葡萄球菌、黄单胞菌、不动杆菌、空气肠杆菌、沙雷氏菌、李斯特菌、单核细胞增多症链球菌、化脓性链球菌、肺炎链球菌、绿链球菌、流感嗜血杆菌、美丽变形杆菌、变形杆菌和脆弱拟杆菌引起的感染特别有效。