1-(2-羟基乙基)-5-氧代吡咯烷-3-羧酸 | 43094-95-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-(2-羟基乙基)-5-氧代吡咯烷-3-羧酸
• 英文名称: N-(2-hydroxyethyl)-2-pyrrolidone-4-carboxylic acid
• 英文别名: 1-(2-Hydroxyethyl)-5-oxopyrrolidine-3-carboxylic acid
• CAS: 43094-95-7
• 化学式: C₇H₁₁NO₄
• mdl: MFCD07357604
• 分子量: 173.169
• InChiKey: LYORUPRFHVMNOI-UHFFFAOYSA-N

物化性质

• 沸点：
  452.7±35.0 °C(Predicted)
• 密度：
  1.401±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933790090

反应信息

• 作为产物：
  描述：

  衣康酸 、 C.I.酸性橙108 以 水 为溶剂， 以71%的产率得到1-(2-羟基乙基)-5-氧代吡咯烷-3-羧酸
  参考文献：
  名称：

  由衣康酸合成可生物降解和可水降解的聚内酰胺酯

  摘要：

  聚内酰胺酯易于由生物基衣康酸制备，并与聚乳酸进行比较。内酰胺环提高了玻璃化转变温度，主链酯基更容易水解，通过在水中搅拌一年完全降解。

  DOI：

  10.1039/c6gc01081d

文献信息

• Extending the chemical product tree: a novel value chain for the production of <i>N</i>-vinyl-2-pyrrolidones from biogenic acids
  作者：Moritz Otto Haus、Yannik Louven、Regina Palkovits

  DOI：10.1039/c9gc01488h

  日期：——

  ethanolamine and hydrogen using small amounts of water as solvent together with solid catalysts. For effective conversion, the optimal catalyst (carbon supported ruthenium) has to hold the ability of activating H2 as well as (imide) CO bonds. The obtained products, N-(2-hydroxyethyl)-2-pyrrolidones, are subsequently converted in a continuous gas phase dehydration over simple sodium-doped silica, with

  从生物平台化学物质可持续生产聚合物显示出减少化学工业对化石资源的依赖的巨大希望。在这种情况下，我们提出了一种新的两步法，从二羧酸（例如琥珀酸和衣康酸）到N-乙烯基-2-吡咯烷酮单体。首先，使用少量的水作为溶剂与固体催化剂一起使生物酸与乙醇胺和氢气反应。为了有效转化，最佳催化剂（碳载钌）必须具有活化H 2以及（酰亚胺）C O键的能力。获得的产品，N-（2-羟乙基）-2-吡咯烷酮随后在简单的钠掺杂二氧化硅上以连续气相脱水的方式转化，具有超过96mol％的优异选择性，并且水是唯一的副产物。在两个工艺步骤中最终产品的收率为≥72mol％，并且由于采用了非均相催化而产生的浪费极少，因此，无论从商业角度还是从绿色化学方面来说，拟议的方法都有望实现。
• FILM FORMING COATING COMPOSITIONS CONTAINING CARBOXAMIDE COALESCING SOLVENTS AND METHODS OF USE
  申请人：Luebke Gary

  公开号：US20130143986A1

  公开（公告）日：2013-06-06

  A film may be formed from film forming compositions which comprise at least one carboxamide based coalescing solvent. These coalescing solvents impart equivalent or improved wet-scrub resistance, block resistance, gloss, dirt pick-up resistance and leveling characteristics to the films on a substrate, without contributing to total VOC levels, when replacing conventional coalescing solvents. The present invention also includes a method for forming a film comprising applying a film forming composition comprising polyunsaturated reactive carboxamides to a substrate and curing the film under ambient conditions. The coalescing carboxamide solvents are suitable for paint, latex based caulk, adhesives and floor care applications.

  可以使用至少一种基于羧酰胺的共溶剂来制备膜形成组合物，从而形成一种电影。当取代传统的共溶剂时，这些共溶剂可以赋予膜在基材上等效或改善的耐湿擦洗性、阻塞性、光泽度、防尘性和平整特性，而不会对总挥发性有所贡献。本发明还包括一种方法，用于形成膜，包括将含有多不饱和反应性羧酰胺的膜形成组合物涂覆在基材上，并在环境条件下固化膜。这些共溶剂适用于涂料、乳胶基密封胶、粘合剂和地面保养应用。
• Salts of N-substituted-2-pyrrolidone-4-carboxylic acids as humectants
  申请人：PFIZER INC.

  公开号：EP0069512A2

  公开（公告）日：1983-01-12

  Alkali metal salts of N-(C1-C5)alkyl- or N-(C1-C5)hydroxyalkyl-2-pyrrolidone-4-carboxylic acids and compositions containing them are useful as humectants, particularly in topical cosmetic and pharmaceutical compositions.

  N-(C1-C5)alkyl- 或 N-(C1-C5)hydroxyalkyl-2-pyrrolidone-4-carboxylic acids 的碱金属盐和含有它们的组合物可用作保湿剂，特别是在局部化妆品和药物组合物中。
• Biorenewable, water-degradable polymers and co-polymers
  申请人：University of Florida Research Foundation, Inc.

  公开号：US10738151B2

  公开（公告）日：2020-08-11

  Various embodiments relate to biorenewable and water-degradable co-polymers and methods of producing co-polymers that include a plurality of first monomeric units and a plurality of second monomeric units joined by a plurality of hydrolytically-sensitive ester linkages. Each of the plurality of first monomeric units may be derived from a first monomer. The first monomer may be the product of a reaction between itaconic acid and a first amino acid. Each of the plurality of second monomeric units may be derived from a second monomer. The second monomer may be the product of a reaction between itaconic acid and a second amino acid. The co-polymers may be a product of the reaction of the first monomer and the second monomer in the presence of a diol. The co-polymers may have a glass transition temperature of about 50° C. or greater.

  各种实施方案涉及生物可再生和水可降解共聚物以及生产共聚物的方法，这些共聚物包括多个第一单体单元和多个第二单体单元，它们通过多个水解敏感的酯键连接。多个第一单体单元中的每一个都可以来自第一单体。第一单体可以是衣康酸和第一氨基酸反应的产物。多个第二单体单元中的每一个都可以来自第二单体。第二单体可以是衣康酸和第二氨基酸反应的产物。共聚物可以是第一单体和第二单体在二元醇存在下反应的产物。共聚物的玻璃化温度可为约 50 摄氏度或更高。
• COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED IN THE 4 POSITION WITH A CARBOXYLIC ACID OR AMIDE, AND AT LEAST ONE DIRECT DYE OR A PIGMENT FOR DYEING KERATIN FIBRES
  申请人：Sabelle Stéphane

  公开号：US20130167307A1

  公开（公告）日：2013-07-04

  The invention relates to a composition for dyeing keratin fibres, and in particular human keratin fibres such as the hair, comprising at least one 2-pyrrolidone functionalized in the 4 position with a carboxylic acid or amide radical, and at least one hydrophobic direct dye or a pigment; a dyeing process using this composition. Similarly, the invention relates to the use of the said pyrrolidone combined with a direct dye or a pigment for dyeing keratin fibres, and especially to the use of the said pyrrolidone for improving the colour uptake onto the fibres of direct dyes that are sparingly soluble or insoluble in aqueous-alcoholic supports. The invention also relates to novel pyrrolidone derivatives. The present invention makes it possible in particular to obtain direct dyeing on keratin fibres that is fast, resistant to washing, chromatic and powerful.