Chlorfenvinfos is an amber-colored liquid with a mild chemical odor. Used for control of ticks, flies, lice, and mites on cattle and for blowfly, lice, ked, and itchmite on sheep. Controls fleas and mites on dogs; not used on cats. Applied on organic wastes and breeding places of fly larvae. Also used as a foliage insecticide for potatoes, rice, maize, and sugar cane. Used to control soil insects. (EPA, 1998)
颜色/状态：
Colorless liquid
气味：
Mild odor
溶解度：
In water, 124 mg/l at 20 °C
蒸汽压力：
7.5X10-6 mm Hg @ 25 °C
稳定性/保质期：
SLOWLY HYDROLYZED BY WATER OR ACID, 50% DECOMP OCCURS AT 38 °C IN GREATER THAN 700 HR AT PH 1.1, GREATER THAN 400 HR AT PH 9.1, BUT UNSTABLE IN ALKALI--AT 20 °C 50% LOSS OCCURS IN 1.28 HR AT PH 13.
分解：
When heated to decomposition it emits very toxic fumes of hydrogen chloride and POx /phosphorus oxides/.
MICROSOMES FROM RABBIT LIVERS WERE INCUBATED WITH CHLORFENVINPHOS. OXIDATIVE CLEAVAGE OF ESTER BOND ... /OCCURRED/ VIA HYDROXYLATION ... TO GIVE 1-HYDROXYETHYL PHOSPHATE TRIESTER. THIS ... INTERMEDIATE BROKE DOWN ... TO 2-CHLORO-1-(2,4-DICHLOROPHENYL) VINYL ETHYL HYDROGEN PHOSPHATE. OXIDATIVE CLEAVAGE OF THE C-O BOND, RATHER THAN HYDROLYSIS OF THE P-O BOND, YIELDED ACETALDEHYDE ... .
AFTER ORAL ADMIN TO RATS AND DOGS...IN RATS, 32.3% OF DOSE WAS ACCOUNTED FOR BY 2-CHLORO-1-(2,4-DICHLOROPHENYL) VINYL MONOETHYL PHOSPHATE; 41% BY 1-(2',4'-DICHLOROPHENYL) ETHYL BETA-D-GLUCOPYRANOSIDURONIC ACID; 7% BY 2,4-DICHLOROMANDELIC ACID; 2.6% BY 2,4-DICHLOROPHENYLETHANEDIOL GLUCURONIDE; AND 4.3% BY 2,4-DICHLOROHIPPURIC ACID. IN DOGS THIS WAS 69.6% 2-CHLORO-1-(2,4-DICHLOROPHENYL) VINYL MONOETHYL PHOSPHATE; 3.6% 1-(2',4'-DICHLOROPHENYL) ETHYL BETA-D-GLUCOPYRANOSIDURONIC ACID; 13.4% /UNIDENTIFIED COMPD/; 2.7% 2,4-DICHLOROPHENYLETHANEDIOL GLUCURONIDE. AFTER IV ADMINISTRATION, CHLORFENVINPHOS WAS RAPIDLY METABOLIZED TO O-DESETHYL ANALOG (2-CHLORO-1-(2,4-DICHLOROPHENYL) VINYL MONOETHYL PHOSPHATE) (83%), 2,4-DICHLOROMANDELIC ACID (9%), AND 1-(2',4'-DICHLOROPHENYL) ETHYL BETA-D-GLUCOPYRANOSIDURONIC ACID (8%) IN DOGS.
来源:Hazardous Substances Data Bank (HSDB)
代谢
氯芬vinfos在人体内的一种代谢物是去乙基氯vinfos。
One metabolite of chlorfenvinphos in humans is desethyl chlorvinphos.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
暴露途径
这种物质可以通过吸入、皮肤接触和摄入被身体吸收。
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
毒理性
吸入症状
瞳孔收缩，肌肉痉挛，过度流涎。出汗。恶心。眩晕。呼吸困难。头痛。抽搐。昏迷。症状可能会延迟出现。
Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Dizziness. Laboured breathing. Headache. Convulsions. Unconsciousness. Symptoms may be delayed.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
毒理性
皮肤症状
可能会被吸收！请参见吸入部分。
MAY BE ABSORBED! See Inhalation.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
毒理性
眼睛症状
模糊的视力。
Blurred vision.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
毒理性
摄入症状
腹部绞痛。腹泻。呕吐。虚弱。抽搐。请参见吸入部分。
Abdominal cramps. Diarrhoea. Vomiting. Weakness. Convulsions. See Inhalation.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
PEAK CONCN OF RADIOACTIVE MATERIAL IN URINE OF STEERS, AFTER SPRAY APPLICATION OF (32)P-LABELED CHLORFENVINPHOS, OCCURRED IN SAMPLES AT 3 HR POST-TREATMENT. ... RESIDUES OF CHLORFENVINPHOS ... WERE BELOW LIMITS OF DETECTION IN ORGANS OF EXPOSED SHEEP. RESIDUE LEVELS NEVER REACHED 0.1 PPM. AFTER ORAL ADMIN TO RATS & DOGS, (14)C CHLORFENVINPHOS WAS RAPIDLY METABOLIZED AND EXCRETED. ABOUT 90% WAS ELIMINATED IN URINE; REMAINDER, VIA FECES AND, TO A LESSER EXTENT, VIA EXPIRED GASES. ... STUDIES HAVE SHOWN THAT THIS COMPD REACTED WITH AND WAS BOUND BY PROTEINS IN BLOOD PLASMA OF MAMMALS AND IN HOMOGENATES OF HOUSE FLY HEADS.
Dosage levels of 112 mg/hr/man /applied to left forearm/ ... produced blood levels of 0.012 ppm or more measured 24 hr after exposure. ... 70.8 mg/hr/man caused ... a blood level of 0.006 ppm 24 hr after exposure.
Oral dosages as high as 1 mg/kg did not affect cholinesterase or the awake-sleep cycle of rats. At dosages over 2 mg/kg, the cholinesterase activities of both brain & red cells were significantly decr, & the spontaneous EEG showed a prominent arousal pattern with suppression of curves characteristic of sleep. Maximal inhibition of brain cholinesterase occurred 3 hr after dosing & lasted for more than 72 hr.
[EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
申请人：GILEAD APOLLO LLC
公开号：WO2017075056A1
公开（公告）日：2017-05-04
The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
[EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
申请人：BASF SE
公开号：WO2014206910A1
公开（公告）日：2014-12-31
The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
