1-(4-(5-氧代-1-苯基-2-硫代咪唑烷-4-基)丁基)-3-苯基硫脲 | 5657-26-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 1-(4-(5-氧代-1-苯基-2-硫代咪唑烷-4-基)丁基)-3-苯基硫脲
• 英文名称: 1-[4-(5-oxo-1-phenyl-2-thioxo-imidazolidin-4-yl)-butyl]-3-phenyl-thiourea
• 英文别名: N-[4-(5-oxo-1-phenyl-2-thioxo-imidazolidin-4-yl)-butyl]-N'-phenyl-thiourea；N-[4-(5-Oxo-1-phenyl-2-thioxo-imidazolidin-4-yl)-butyl]-N'-phenyl-thioharnstoff；1-(4-(5-Oxo-1-phenyl-2-thioxoimidazolidin-4-yl)butyl)-3-phenylthiourea；1-[4-(5-oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl)butyl]-3-phenylthiourea
• CAS: 5657-26-1
• 化学式: C₂₀H₂₂N₄OS₂
• 分子量: 398.553
• InChiKey: BUPYRERCBPFRFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  L-赖氨酸 、 硫代异氰酸苯酯 在 吡啶 、 sodium hydroxide 作用下， 生成 1-(4-(5-氧代-1-苯基-2-硫代咪唑烷-4-基)丁基)-3-苯基硫脲
  参考文献：
  名称：

  Among the Missing: Content on Lesbian and Gay People in Social Work Journals

  摘要：

  在社会工作文献中，关于同性恋和同性恋者的问题几乎没有被提及。本研究考察了1988年至1997年间在四本主要社会工作期刊上发表的关于同性恋的文章内容。文章根据关注点被编码为HIV/AIDS与同性恋社区或其他与女同性恋者和男同性恋者有关的问题。文章还被编码为以客户为中心、以工作者为中心或宏观为中心。在77篇关于同性恋的文章中，三分之二集中于HIV/AIDS。大多数文章反映了对同性恋者的以问题为导向的观点；很少有文章涉及异性恋主义或环境干预。需要更多关注同性恋者和女同性恋者优势、异性恋主义条件及社会公正的文献。

  DOI：

  10.1093/sw/47.4.345

文献信息

• Sjoequist, Arkiv foer Kemi, 1957, vol. 11, p. 129,130,132
  作者：Sjoequist

  DOI：——

  日期：——
• Pharmaceutical Compositions For and Methods of Inhibiting Hcv
  申请人：Huang Mingjun

  公开号：US20080207760A1

  公开（公告）日：2008-08-28

  The present invention relates generally to replicase complex defect inducers and pharmaceutical compositions containing such inducers. Methods of developing mutants that are resistant to replicase complex defect inducers are also provided. Further included are mutants that can be used in screening for replicase complex defect inducers. Methods of screening test compounds for the ability to induce the formation of replicase complex defects are also described. Also included are methods of inhibition of HCV replication by replicase complex defect inducers.
• Among the Missing: Content on Lesbian and Gay People in Social Work Journals
  作者：R. Van Voorhis、M. Wagner

  DOI：10.1093/sw/47.4.345

  日期：2002.10.1

  Lesbian and gay issues are barely visible in the social work literature. This study examined the content of articles on homosexuality that were published in four major social work journals between 1988 and 1997. Articles were coded according to their focus on either HIV/AIDS and the gay community or other issues pertaining to lesbians and gay men. Articles were also coded as client focused, worker focused, or macro focused. Two-thirds of the 77 articles published on homosexuality focused on HIV/AIDS. Most articles reflected a problem-oriented view of gay and lesbian people; few addressed heterosexism or environmental interventions. More literature is needed that focuses on strengths, heterosexist conditions, and social justice for lesbian and gay people.

  在社会工作文献中，关于同性恋和同性恋者的问题几乎没有被提及。本研究考察了1988年至1997年间在四本主要社会工作期刊上发表的关于同性恋的文章内容。文章根据关注点被编码为HIV/AIDS与同性恋社区或其他与女同性恋者和男同性恋者有关的问题。文章还被编码为以客户为中心、以工作者为中心或宏观为中心。在77篇关于同性恋的文章中，三分之二集中于HIV/AIDS。大多数文章反映了对同性恋者的以问题为导向的观点；很少有文章涉及异性恋主义或环境干预。需要更多关注同性恋者和女同性恋者优势、异性恋主义条件及社会公正的文献。