1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐 | 74298-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐
• 英文名称: Chlorimidazole hydrochloride
• 英文别名: chlormidazole hydrochloride；Hydrochlorid v. 2-Methyl-1-(4-chlorbenzyl)-benzimidazol；1-[(4-chlorophenyl)methyl]-2-methylbenzimidazole;hydrochloride
• CAS: 74298-63-8
• 化学式: C₁₅H₁₃ClN₂*ClH
• 分子量: 293.196
• InChiKey: MHMTXDMLQZHXRZ-UHFFFAOYSA-N

物化性质

• 熔点：
  227-228°
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  0.47
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  19.7
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 储存条件：
  -20°C

制备方法与用途

生物活性

氯咪达唑盐酸盐是一种抗真菌剂，能够抑制多种真菌和部分革兰氏阳性球菌。该药物可用于治疗指甲和皮肤的真菌及细菌感染，包括指间和甲周真菌感染。

靶点

IC50: 真菌

文献信息

• [EN] DERMAL COMPOSITIONS CONTAINING UNNATURAL HYGROSCOPIC AMINO ACIDS<br/>[FR] COMPOSITIONS DERMATOLOGIQUES CONTENANT DES AMINOACIDES HYGROSCOPIQUES NON NATURELS
  申请人：MEDPHARM LTD

  公开号：WO2014072747A1

  公开（公告）日：2014-05-15

  Unnatural, hygroscopic amino acids are useful to enhance the moisture retention and uptake properties of skin. In particular, such amino acids are N-hydroxyserine, N- hydroxyglycine, L-homoserine,alpha-hydroxyglycine, 2-(aminooxy) -2-hydroxyacetic acid, 2-hydroxy-2-(hydroxyamino) acetic acid, 2- (aininooxy)acetic acid, and combinations thereof.

  不自然的、亲水性的氨基酸对增强皮肤的保湿和吸湿性能是有用的。特别是，这些氨基酸包括N-羟基丝氨酸、N-羟基甘氨酸、L-同丝氨酸、α-羟基甘氨酸、2-(氨氧基)-2-羟基乙酸、2-羟基-2-(羟氨基)乙酸、2-(氨氧基)乙酸，以及它们的组合。
• GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
  申请人：Cai Jianfeng

  公开号：US20150274782A1

  公开（公告）日：2015-10-01

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一种新型类别的抗微生物药物，称为γ-AA肽。当前发明提供了各种类别的γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂质化γ-AA肽。本发明的γ-AA肽被设计为具有抗微生物活性，同时稳定且无毒。γ-AA肽似乎也不会导致被治疗微生物体内微生物产生抗药性。因此，所披露的γ-AA肽可用于治疗与病原微生物相关的各种医疗状况。
• DERMAL COMPOSITIONS CONTAINING UNNATURAL HYGROSCOPIC AMINO ACIDS
  申请人：MEDPHARM LIMITED

  公开号：US20150328109A1

  公开（公告）日：2015-11-19

  Unnatural, hygroscopic amino acids are useful to enhance the moisture retention and uptake properties of skin. In particular, such amino acids are N-hydroxyserine, N-hydroxyglycine, L-homoserine, alpha-hydroxyglycine, 2-(aminooxy)-2-hydroxyacetic acid, 2-hydroxy-2-(hydroxyamino) acetic acid, 2-(aininooxy)acetic acid, and combinations thereof.

  不自然的、亲水性的氨基酸对于增强皮肤的保湿性和吸水性非常有用。特别是，这些氨基酸包括N-羟基丝氨酸、N-羟基甘氨酸、L-脯氨酸、α-羟基甘氨酸、2-(氨氧基)-2-羟基乙酸、2-羟基-2-(羟胺基)乙酸、2-(氨氧基)乙酸和它们的组合。
• Absorbent medical articles
  申请人：3M Innovative Properties Company

  公开号：EP2462956A1

  公开（公告）日：2012-06-13

  Medical articles including an absorbent layer, a backing layer and an optional liquid permeable facing layer are disclosed. The construction of the medical article is such that volumetric expansion of the absorbent layer is allowed in directions parallel to the surface of the backing layer as the absorbent layer absorbs moisture. The medical article may include a debonding agent located between the absorbent layer and the backing layer. The absorbent layer is operably attached to the backing layer. When the absorbent layer absorbs moisture, e.g., wound exudates, at least a portion of the absorbent layer detaches from the backing layer such that the absorbent layer can expand and move relative to the backing. The debonding agent facilitates this change from attachment to detachment of the absorbent layer to the backing. The medical articles of the present invention may also be constructed such that a portion of the front surface of the backing layer located directly opposite the absorbent layer is free of adhesive. The adhesive free area or areas may be provided in place of a physical debonding agent or in addition to a physical debonding agent.

  本发明公开了包括吸水层、背衬层和可选液体渗透面层的医疗用品。医疗用品的结构允许吸收层在吸收湿气时在与背衬层表面平行的方向上发生体积膨胀。医疗用品可包括位于吸水层和背衬层之间的脱粘剂。吸水层可操作地附着在背衬层上。当吸水层吸收水分（如伤口渗出物）时，吸水层的至少一部分会从背衬层脱落，这样吸水层就可以膨胀并相对于背衬层移动。脱粘剂可促进吸收层与背衬层从附着到分离的这种变化。本发明的医疗用品还可以这样构造，即背衬层前表面与吸收层直接相对的部分没有粘合剂。无粘合剂区域可代替物理脱粘剂或作为物理脱粘剂的补充。
• γ-AApeptides with potent and broad-spectrum antimicrobial activity
  申请人：Cai Jianfeng

  公开号：US10144764B2

  公开（公告）日：2018-12-04

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一类名为γ-AA肽的新型抗菌剂。本发明提供了各种类型的 γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂化γ-AA肽。本发明中的γ-AA 肽具有抗菌活性，同时稳定无毒。γ-AA肽似乎也不会导致被处理微生物产生抗药性。因此，所公开的γ-AA 肽可用于治疗与病原微生物有关的各种病症。