1-(二氯甲基)异喹啉 | 88237-16-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 1-(二氯甲基)异喹啉
• 英文名称: 1-dichloromethylisoquinoline
• 英文别名: 1-(Dichloromethyl)isoquinoline
• CAS: 88237-16-5
• 化学式: C₁₀H₇Cl₂N
• 分子量: 212.078
• InChiKey: NJQVYZQWQIEQKH-UHFFFAOYSA-N

物化性质

• 熔点：
  57-59 °C(Solv: ligroine (8032-32-4))
• 沸点：
  331.4±27.0 °C(Predicted)
• 密度：
  1.354±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(二氯甲基)异喹啉 以 二甲基亚砜 为溶剂， 反应 8.0h， 以95%的产率得到异喹啉-1-甲醛
  参考文献：
  名称：

  Isoquinoline in the synthesis of 1-dichloromethylisoquinoline and 1-formylisoquinoline

  摘要：

  By the reaction of isoquinoline with CCl(4) and methanol catalyzed by iron-containing compounds a synthesis was performed of 1-dichloromethylisoquinoline that was quantitatively converted into 1-formylisoquinoline by the treatment with dimethyl sulfoxide.

  DOI：

  10.1134/s1070428010050192
• 作为产物：
  描述：

  异喹啉 、 四氯化碳 在 iron(III)-acetylacetonate 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以59%的产率得到1-(二氯甲基)异喹啉
  参考文献：
  名称：

  Isoquinoline in the synthesis of 1-dichloromethylisoquinoline and 1-formylisoquinoline

  摘要：

  By the reaction of isoquinoline with CCl(4) and methanol catalyzed by iron-containing compounds a synthesis was performed of 1-dichloromethylisoquinoline that was quantitatively converted into 1-formylisoquinoline by the treatment with dimethyl sulfoxide.

  DOI：

  10.1134/s1070428010050192

文献信息

• α-Methyl Functionalization of Electron-Poor Heterocycles¹: Free Radical Chlorination
  作者：George R. Newkome、Garry E. Kiefer、YUAN-JIAO Xia、Vinod K. Gupta

  DOI：10.1055/s-1984-30930

  日期：——
• Katagiri, Nobuya; Niwa, Ryuji; Furuya, Yoichi, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 6, p. 1833 - 1841
  作者：Katagiri, Nobuya、Niwa, Ryuji、Furuya, Yoichi、Kato, Tetsuzo

  DOI：——

  日期：——
• KATAGIRI, NOBUYA;NIWA, RYUJI;FURUYA, YOICHI;KATO, TETSUZO, CHEM. AND PHARM. BULL., 1983, 31, N 6, 1833-1841
  作者：KATAGIRI, NOBUYA、NIWA, RYUJI、FURUYA, YOICHI、KATO, TETSUZO

  DOI：——

  日期：——
• NEWKOME, G. R.;KIEFER, G. E.;XIA, YUAN-JIAO;GUPTA, V. K., SYNTHESIS, BRD, 1984, N 8, 676-679
  作者：NEWKOME, G. R.、KIEFER, G. E.、XIA, YUAN-JIAO、GUPTA, V. K.

  DOI：——

  日期：——
• Process for Producing Olefin Copolymerization Catalyst and Process for Producing Olefin Copolymer
  申请人：NAKAHARA Shinya

  公开号：US20090018012A1

  公开（公告）日：2009-01-15

  A process for producing an olefin copolymerization catalyst, comprising the step of contacting, with one another, (A) a solid catalyst component containing a titanium atom, a magnesium atom and a halogen atom, (B) an organoaluminum compound and/or organoaluminumoxy compound, and (C) a nitrogen-containing aromatic heterocyclic compound, whose one or more carbon atoms adjacent to its nitrogen atom are linked to an electron-withdrawing group, or a group containing an electron-withdrawing group; and a process for producing an olefin copolymer using the an olefin copolymerization catalyst.