1-(吡啶-1-鎓-1-基甲基)苯并三唑 | 125713-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 中文名称: 1-(吡啶-1-鎓-1-基甲基)苯并三唑
• 英文名称: 1-((1H-Benzotriazol-L-yl)methyl)pyridinium
• 英文别名: 1-(pyridin-1-ium-1-ylmethyl)benzotriazole
• CAS: 125713-96-4
• 化学式: C12H11N4+
• 分子量: 211.24
• InChiKey: NEMINUYEACMXFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：Shimizu Kazuo

  公开号：US20120015972A1

  公开（公告）日：2012-01-19

  The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. That is, the present invention relates to indolizine derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In the formula, ring U represents aryl or heteroaryl; R 1 represents halogen, a hydroxy group or the like; R 2 represents halogen, a hydroxy group, alkyl, alkoxy, alkyl substituted by fluorine, alkoxy substituted by fluorine or the like; m represents a number from 0 to 2; n represents a number from 0 to 3; and R 3 represents hydrogen, fluorine or the like.

  本发明提供了作为与异常血清尿酸水平相关的疾病的预防或治疗剂的化合物。也就是说，本发明涉及由以下式（I）所表示的吲哚啉衍生物，具有黄嘌呤氧化酶抑制活性，并且作为与血清尿酸水平异常相关的疾病的预防或治疗剂，其前药，其盐或类似物。在该式中，环U代表芳基或杂环芳基；R1代表卤素，羟基或类似物；R2代表卤素，羟基，烷基，烷氧基，氟取代的烷基，氟取代的烷氧基或类似物；m代表0到2之间的数字；n代表0到3之间的数字；R3代表氢，氟或类似物。
• US8748452B2
  申请人：——

  公开号：US8748452B2

  公开（公告）日：2014-06-10