1-N,1-N-二乙基-2-甲基苯-1,4-二胺 | 2628-71-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-N,1-N-二乙基-2-甲基苯-1,4-二胺
• 英文名称: N,N-diethyl-2-methyl-p-phenylenediamine
• 英文别名: 2-methyl-4-amino-N,N-diethylaniline；N¹,N¹-diethyl-2-methyl-p-phenylenediamine；N¹,N¹-Diaethyl-2-methyl-p-phenylendiamin；5-Amino-2-diaethylamino-toluol；N1,N1-diethyl-2-methyl-benzene-1,4-diamine；N,N-diethyl-2-methyl-1,4-phenylenediamine；N1,N1-Diethyl-2-methylbenzene-1,4-diamine；1-N,1-N-diethyl-2-methylbenzene-1,4-diamine
• CAS: 2628-71-9
• 化学式: C₁₁H₁₈N₂
• 分子量: 178.277
• InChiKey: NXVHEHXRZVQDCR-UHFFFAOYSA-N

物化性质

• 沸点：
  284.9±20.0 °C(Predicted)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2921590090

反应信息

• 作为反应物：
  描述：

  4-(3-methyl-5-oxo-2,5-dihydro-pyrazol-1-yl)-benzenesulfonic acid amide 、 1-N,1-N-二乙基-2-甲基苯-1,4-二胺 在 水 、 sodium carbonate 、 silver(I) chloride 作用下， 生成 4-[4-(4-diethylamino-2-methyl-phenylimino)-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl]-benzenesulfonic acid amide
  参考文献：
  名称：

  Azomethine Dyes. I. Color and Constitution of Pyrazolone Azomethine Dyes

  摘要：

  DOI：

  10.1021/ja01147a011
• 作为产物：
  描述：

  4-硝基-2-甲苯胺 在 盐酸 、 sodium hydroxide 、 乙醇 、 碘乙烷 、 锌 作用下， 反应 2.0h， 生成 1-N,1-N-二乙基-2-甲基苯-1,4-二胺
  参考文献：
  名称：

  Bernthsen, Chemische Berichte, 1892, vol. 25, p. 3135

  摘要：

  DOI：

文献信息

• Isoxazole carboxamide derivatives as ghrelin receptor modulators
  申请人：Liu Gang

  公开号：US20060089398A1

  公开（公告）日：2006-04-27

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.

  本发明涉及式(I)的化合物，或其在治疗上适用的盐或前药，该化合物的制备，含有该化合物的组合物以及在预防或治疗由胃饥素调节的疾病中使用该化合物，包括厌食症、癌症恶病质、进食障碍、与年龄相关的身体组成下降、体重增加、肥胖和糖尿病。
• Tetraline derivatives as ghrelin receptor modulators
  申请人：Liu Bo

  公开号：US20050014794A1

  公开（公告）日：2005-01-20

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.

  本发明涉及式(I)的化合物，或其在治疗上适宜的盐或前药，该化合物的制备，含有该化合物的组合物以及该化合物在预防或治疗由胃泌素调节的疾病中的应用，包括厌食症、癌症恶病质、进食障碍、与年龄相关的身体组成下降、体重增加、肥胖和糖尿病。
• METHOD FOR PURIFYING FREE-BASE P-PHENYLENEDIAMINE-TYPE PHOTOGRAPHIC COLOR DEVELOPERS
  申请人：——

  公开号：US20030017426A1

  公开（公告）日：2003-01-23

  A process for purifying p-phenylenediamine color developers in their free-base form. The process includes subjecting a solution containing p-phenylenediamine-type free base color developer to short path distillation which includes at least one of falling film evaporator, thin film evaporator, wiped film evaporator, or short-path evaporator. Another aspect is a method for preparing an acid salt from a p-phenylenediamine free base color developer. The method includes the steps of: a) dissolving a purified p-phenylenediamine free base derived from the short path distillation process in an organic solvent; b) contacting the dissolved free base distillate with an appropriate mineral acid; and c) crystallizing the color developer in the acid salt form.

  一种用于纯化游离态p-苯二胺显色剂的方法。该方法包括将含有p-苯二胺游离基显色剂的溶液经过短程蒸馏，其中至少包括下列一种：降膜蒸发器、薄膜蒸发器、刮板蒸发器或短程蒸馏器。另一方面，该方法还包括制备p-苯二胺游离基显色剂酸盐的方法。该方法包括以下步骤：a）将经过短程蒸馏过程得到的纯化的p-苯二胺游离基溶解在有机溶剂中；b）将溶解的游离基馏分物与适当的矿酸接触；c）以酸盐形式结晶显色剂。
• Method for preparing an acid salt of p-phenylenediamine-type photographic color developers
  申请人：——

  公开号：US20030022114A1

  公开（公告）日：2003-01-30

  A process for purifying p-phenylenediamine color developers in their free-base form. The process includes subjecting a solution containing p-phenylenediamine-type free base color developer to short path distillation which includes at least one of falling film evaporator, thin film evaporator, wiped film evaporator, or short-path evaporator. Another aspect is a method for preparing an acid salt from a p-phenylenediamine free base color developer. The method includes the steps of: a) dissolving a purified p-phenylenediamine free base derived from the short path distillation process in an organic solvent; b) contacting the dissolved free base distillate with an appropriate mineral acid; and c) crystallizing the color developer in the acid salt form.

  一种用于纯化游离基形式的p-苯二胺显影剂的过程。该过程包括将含有p-苯二胺型游离基显影剂的溶液经过短程蒸馏，其中包括至少一个下降薄膜蒸发器、薄膜蒸发器、刮板蒸发器或短程蒸馏器。另一个方面是从p-苯二胺游离基显影剂制备酸盐的方法。该方法包括以下步骤：a）将从短程蒸馏过程中获得的纯化p-苯二胺游离基溶解在有机溶剂中；b）将溶解的游离基馏分与适当的矿酸接触；c）以酸盐形式结晶显影剂。
• Antifungal Agents
  申请人：Thomson Samantha Patricia

  公开号：US20080161302A1

  公开（公告）日：2008-07-03

  Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: R1, R2, R3, R4, R5, R6, R7, X and X 1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

  式(I)的化合物及其药学上可接受的盐可用于治疗，例如作为抗真菌剂：其中：R1、R2、R3、R4、R5、R6、R7、X和X1如此定义。还提供了式(I)的某些化合物。式(T)的化合物及其农业上可接受的盐也可用作农业杀菌剂。