1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)-1H-苯并咪唑硫酸盐 | 17162-20-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)-1H-苯并咪唑硫酸盐
• 英文名称: Clemizole sulfate
• 英文别名: 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;sulfuric acid
• CAS: 17162-20-8
• 化学式: C19H22ClN3O4S
• 分子量: 423.9
• InChiKey: RZENSCAUEVAXIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Medical composition for external application
  申请人：Kao Corporation

  公开号：EP0179277A1

  公开（公告）日：1986-04-30

  57 A medical composition for external application comprises a dialkyl phosphate represented by the formula: wherein R, and R2 independently represent a hydrocarbon group having from 6 to 24 carbon atoms, R3 and R. independently represent hydrocarbon group having from 2 to 6 carbon atoms, m and n indepedently represent a value of from 0 to 20, and x represents a hydrogen atom or a salt of an alkali metal and the like. In the presence of the dialkyl phosphate, percutaneous intake of medically active ingredients is highly enhanced. Examples of the medically active ingredients directed to in the invention include antiinflammatory agents such as ethyl aminobenzoate; adrenocortical hormones such as hydrocortisone; etc. The inventive composition is highly safe without giving any stimulation to the skin.

  57 用于外用的医疗组合物包括由式表示的磷酸二烷基酯：其中 R 和 R2 独立地代表具有 6 至 24 个碳原子的烃基，R3 和 R.独立地代表具有 2 至 6 个碳原子的烃基，m 和 n 独立地代表 0 至 20 的值，x 代表氢原子或碱金属盐等。 在磷酸二烷基酯存在的情况下，经皮摄入医疗活性成分的效果非常好。 本发明所涉及的医疗活性成分包括抗炎剂（如氨基苯甲酸乙酯）、肾上腺皮质激素（如氢化可的松）等，本发明组合物非常安全，不会对皮肤造成任何刺激。
• MICROCAPSULE, TREATMENT LIQUID CONTAINING MICROCAPSULES, AND TEXTILE STRUCTURE HAVING MICROCAPSULES STUCK THERETO
  申请人：KANEBO, LTD.

  公开号：EP0436729A1

  公开（公告）日：1991-07-17

  This invention relates to a microcapsule having a particle diameter of 2 to 300 µm and comprising at least such substances as acting to improve physiological conditions of human skin, for example, substances exhibiting such effects as skin whitening, aging preventive, humidity preservable, itch suppressive, pain-killing, or antiphlogistic ones, and/or aromatic agents contained within the filmy coating of synthetic high molecular substance thereof. The microcapsule is not broken when making, processing, or laundering the textile structure, however, is gradually broken when the textile structure is put on the human body, used for the other purpose, or subjected to intentional application of friction or pressure thereto, and releases acting substances contained therein. Treatment liquid comprising such microcapsules and binder, preferably containing spraying agent, adapt the microcapsules to tightly stick to textile structures as stocking, underwear, and bedclothes, thereby providing a textile structure to exhibit the aforesaid effects.

  本发明涉及一种微胶囊，其颗粒直径为 2 至 300 微米，至少含有能改善人体皮 肤生理状况的物质，例如，具有美白、防老化、防潮、止痒、止痛或抗炎等功效的物 质，和/或在其合成高分子物质的丝状涂层中含有的芳香剂。在制作、加工或洗涤织物结构时，微胶囊不会破损，但当织物结构穿在人体上、用于其他目的或受到有意的摩擦或压力时，微胶囊会逐渐破损，并释放出其中所含的作用物质。由这种微胶囊和粘合剂（最好含有喷洒剂）组成的处理液可以使微胶囊紧紧地粘在丝袜、内衣和床上用品等纺织品结构上，从而使纺织品结构显示出上述效果。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• ADVANCED DRUG DEVELOPMENT AND MANUFACTURING
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519A2

  公开（公告）日：2009-08-05
• X-RAY FLUORESCENCE ANALYSIS METHOD
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519B1

  公开（公告）日：2012-08-01