正丙基二氯硫膦 | 2524-01-8

• 物质功能分类: 化学试剂 - 有机试剂 - 膦配体
• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机硫代磷化合物
• 中文名称: 正丙基二氯硫膦
• 英文名称: Propanthiophosphonsaeuredichlorid
• 英文别名: Propylphosphonothioic dichloride；dichloro-propyl-sulfanylidene-λ5-phosphane
• CAS: 2524-01-8
• 化学式: C₃H₇Cl₂PS
• mdl: MFCD00798601
• 分子量: 177.034
• InChiKey: WELFPYZEJACWRM-UHFFFAOYSA-N

物化性质

• 物理描述：
  This material is a chemical weapon precursor which is similar to methyl phosphonothioic dichloride. See the chemical datasheet for methyl phosphonothioic dichloride for more information.

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2930909027

反应信息

• 作为反应物：
  描述：

  正丙基二氯硫膦 在 硫化氢 作用下， 生成 trans-Propyl-thiono-phosphin-sulfid
  参考文献：
  名称：

  Thionophosphine Sulfides. I. Preparation and Use in the Friedel-Crafts Reaction¹

  摘要：

  DOI：

  10.1021/jo01058a017
• 作为产物：
  描述：

  dichloropropylphosphine 在 三氯化铝 、 sulfur 作用下， 生成 正丙基二氯硫膦
  参考文献：
  名称：

  Ochlobystin; Sacharkin, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958, p. 1006;engl.Ausg.S.977

  摘要：

  DOI：

文献信息

• Mass spectral characterization of the CWC-related isomeric dialkyl alkylphosphonothiolates/alkylphosphonothionates under gas chromatography/mass spectrometry conditions
  作者：R. Karthikraj、L. Sridhar、S. Prabhakar、N. Prasada Raju、M. R. V. S. Murty、M. Vairamani

  DOI：10.1002/rcm.6596

  日期：2013.7.15

  (time-of-flight) mass spectrometer, respectively. RESULTS The EI mass spectra of all the compounds had an abundant molecular ion at m/z 182, except in the case of a few selected butyl-substituted compounds, where this ion was of low abundance. The EI fragmentation pathways include α-cleavage, McLafferty rearrangement, McLafferty + 1 rearrangement, O/S-alkyl radical loss, and an alkene loss with a hydrogen

  理由禁化武组织实施的《化学武器公约》（CWC）的列入清单的化学品列为异构的二烷基烷基硫代磷酸二烷基酯和烷基烷基膦酸二烷基酯。必须正确标识PS和PR键的连接性，以验证CWC。本研究证明了在电子电离（EI）或化学电离（CI）条件下通过选择性裂解成功鉴定目标异构体。方法在我们的实验室中，使用既定方法合成了所有研究的异构化合物（共27种），然后使用配备HP-5MS毛细管柱的Agilent 6890气相色谱仪通过EI和CI气相色谱/质谱（GC / MS）进行分析并连接到5973 N质量选择检测器。使用范登杜尔公式计算所有化合物的保留指数（RI）值。还分别使用VG-Autospec（磁性扇区）和JEOL-AccuToF（飞行时间）质谱仪进行了GC / MS / MS和GC / HRMS实验。结果所有化合物的EI质谱在m / z 182处均具有丰富的分子离子，除了少数几种丁基取代的化合物（该离子的丰度较
• Guichard, Chemische Berichte, 1899, vol. 32, p. 1574
  作者：Guichard

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: S: SVol.4a/b, 1.3.10.1.8, page 267 - 269
  作者：

  DOI：——

  日期：——
• SOLID SUPPORT SYNTHESIS: A NEW AND EFFICIENT METHOD FOR FACILE SYNTHESIS OF CYCLIC ALKYLPHOSPHONATES UNDER MILD CONDITIONS
  作者：Rajesh Kumar、A.K. Gupta、Deepak Pardasani、D.K. Dubey、M. P. Kaushik

  DOI：10.1515/hc.2008.14.4.269

  日期：2008.1
• Prediction of Survival in Stage I Lung Carcinoma Patients by Telomerase Function Evaluation
  作者：Antonio Marchetti、Caterina Pellegrini、Fiamma Buttitta、Monica Falleni、Solange Romagnoli、Lara Felicioni、Fabio Barassi、Simona Salvatore、Antonio Chella、Carlo Alberto Angeletti、Massimo Roncalli、Guido Coggi、Silvano Bosari

  DOI：10.1097/01.lab.0000017165.26718.60

  日期：2002.6

  Telomerase activity and telomerase reverse transcriptase (hTERT) expression are elevated in human malignancies. We have investigated telomerase activity measured by the telomeric repeat amplification protocol (TRAP) assay and hTERT levels by real-time RT-PCR in stage I non-small-cell lung carcinomas. The purposes of our study included the comparison of these two techniques in the assessment of telomerase function and the evaluation of their prognostic significance. Telomerase activity and hTERT levels were determined in 90 stage I non-small-cell lung carcinoma patients, using TRAP assay and real-time RT-PCR, respectively. Variables were analyzed by the chi(2) and Fisher exact tests. Survival was analyzed by the Kaplan-Meier method. Multivariate analysis was performed with the Cox's proportional hazards model. Telomerase activity was elevated in 60 (67%) carcinomas. hTERT was elevated in 43 (48%) carcinomas. Only 21 (23%) tumors had low telomerase function by both TRAP and hTERT expression levels. Telomerase activity and hTERT were significantly correlated (p = 0.017), although 35 cases displayed discordant results. Both telomerase activity and hTERT levels were significantly associated with poor patient overall and disease-free survival (p = 0.019 and p = 0.018 for TRAP, and p = 0.011 and p = 0.012 for hTERT, respectively). Among the 21 patients with tumors displaying low telomerase function, defined by both TRAP and hTERT expression levels, only one succumbed to the disease (p = 0.0053). Our results suggest that the two techniques used in this study evaluate separate aspects of telomerase function and their combination provides powerful prognostic information in lung cancer patients.