甲基内吸磷 | 919-86-8

• 物质功能分类: 化学农药原药 - 杀虫剂 - 有机磷杀虫剂
• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机硫代磷化合物
• 中文名称: 甲基内吸磷
• 中文别名: 内吸磷-S-甲基
• 英文名称: demeton-S-methyl
• 英文别名: S-[2-(ethylthio)ethyl] O,O-dimethyl phosphorothioate；1-dimethoxyphosphorylsulfanyl-2-ethylsulfanylethane
• CAS: 919-86-8
• 化学式: C₆H₁₅O₃PS₂
• mdl: MFCD00055464
• 分子量: 230.289
• InChiKey: WEBQKRLKWNIYKK-UHFFFAOYSA-N

物化性质

• 熔点：
  <25℃
• 沸点：
  118℃
• 密度：
  1.207 g/cm3
• 闪点：
  2 °C
• 物理描述：
  Demeton-s-methyl is a pale yellow oil. Used as an insecticide. Not registered as a pesticide in the U.S. (EPA, 1998)
• 颜色/状态：
  Oily colorless to pale yellow liquid
• 气味：
  Unpleasant odor
• 溶解度：
  600 g/kg dichloromethane at 20 °C; 600 g/kg propan-2-ol at 20 °C
• 蒸汽密度：
  Relative vapor density (air = 1): 7.9
• 蒸汽压力：
  3X10-4 mm Hg at 20 °C
• 稳定性/保质期：

  可燃，燃烧时会分解出有毒的氮氧化物、磷氧化物和硫氧化物气体。

• 分解：
  When heated to decomposition it emits toxic fumes of /phosphorous and sulfur oxides/.
• 气味阈值：
  1.0X10-2 mg/L (liqiuid) (detection in water, purity not specified)
• 折光率：
  Index of refraction: 1.5063 at 20 °C/D
• 碰撞截面：
  150.48 Ų [M+Na]+
• 保留指数：
  1628;1579;1596;1628;1628

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  86.1
• 氢给体数：
  0
• 氢受体数：
  5

ADMET

代谢

在植物中，硫乙基团被氧化生成亚砜（氧代乙硫甲烷）和磺酰（脱氧乙硫甲烷磺酰）。水解生成二甲基磷酸。

In plants, the thioethyl group is oxidized to give the sulfoxide (oxydemeton-methyl) and sulfone (demeton-S-methyl sulfone). Hydrolysis gives dimethyl phosphate.

来源:Hazardous Substances Data Bank (HSDB)

代谢

在哺乳动物中，口服给药后，代谢涉及将硫乙基团氧化成亚砜（氧代乙硫甲烷）和磺酰（脱甲硫磷亚砜），以及水解成二甲基磷酸。

In mammals, following oral admin, metab involves oxidation of the thioethyl group to give the sulfoxide (oxydemeton-methyl) & sulfone (demeton-S-methyl sulfone), & hydrolysis to dimethyl phosphate.

来源:Hazardous Substances Data Bank (HSDB)

代谢

给Sprague-Dawley雄性大鼠单次口服剂量为0.1、0.5、5或10毫克/千克或静脉注射剂量为0.5或1毫克/千克的(14)C-甲基对硫磷。另外，给了一些雌性大鼠单次口服剂量为0.5毫克/千克。... 收集了大鼠尿液样本... 进行薄层色谱和放射性计数方法，旨在识别和量化母体化合物和代谢物。从给予单次口服剂量为5或10毫克/千克14C-甲基对硫磷的雄性大鼠中收集了零至八小时和八至二十四小时的样本。约92%的给药放射性在八小时内通过尿液回收。甲基对硫磷的主要代谢途径是侧链的氧化形成相应的亚砜。还观察到同一侧链进一步轻微氧化形成相应的砜。尿液中还鉴定出了三种相应的亚砜、亚砜和砜部分的O-去甲基代谢物，以及另外两种可能的代谢物，这些代谢物可能是由O-甲基磷酸酯基团的裂解以及随后的甲基化和亚砜化步骤产生的。母体化合物甲基对硫磷几乎完全代谢，尿液中未检测到(<1%)。尿样中大约99%的放射性，相当于给药口服剂量的约95%，被识别并量化如下：甲基对硫磷(未改变的母体化合物)，<1%；甲基对硫磷亚砜，58%；甲基对硫磷砜，6%；O-去甲基-甲基对硫磷，6%；O-去甲基-甲基对硫磷亚砜，6%；O-去甲基-甲基对硫磷砜，4%；甲基亚磺酰-2-乙基亚磺酰乙烷，8.4%和甲基亚磺酰-2-乙基亚磺酰乙烷，10.4%。另一种代谢物占尿液中放射性不到1%，未进一步研究。用葡萄糖苷酸酶或磺酸酯酶处理尿液并未表明存在任何葡萄糖苷酸或硫酸盐结合物。

Male Sprague-Dawley rats given single oral doses of 0.1, 0.5, 5 or 10 mg/kg or intravenous doses of 0.5 or 1 mg/kg of (14)C- demeton-S-methyl. Additional female rats were given a single oral dose of 0.5 mg/kg. ... Rat urine samples ... were collected and subjected to thin layer chromatographic and radioactivity counting methods designed to identify and quantitate the parent compound and metabolites. Zero-to-eight hour and eight to 24-hour samples were collected from male rats given a single oral dose of 5 or 10 mg/kg of 14C-demeton-S-methyl. About 92 percent of the administered radioactivity was recovered in the urine within eight hours. The main route of metabolism of demeton-S-methyl was oxidation of the side chain to form the corresponding sulfoxide. Some further slight oxidation of the same side chain to form the corresponding sulfone was also observed. Three corresponding O-demethylated metabolites of the sulfide, sulfoxide and sulfone moieties were also identified in the urine, as were two additional metabolites presumably resulting from cleavage of the O-methylphosphoric ester group and subsequent methylation and sulfoxidation steps. The parent compound, demeton-S-methyl, was nearly completely metabolized and was not detected in the urine (<1 percent). Approximately 99 percent of the radioactivity in the urine samples, equivalent to about 95 percent of the administered oral doses, was identified and quantitated as follows: demeton-S-methyl (unchanged parent compound), < 1 percent, demeton-S-methyl sulfoxide, 58 percent; demeton-S-methyl sulfone, 6 percent; O-demethyl-demeton - S-methyl, 6 percent; O-demethyl-demeton-D-methyl sulfoxide, 6 percent; O-demethyl-demeton-S-methyl sulfone, 4 percent; methyl sulfinyl-2-ethyl sulfinyl ethane, 8.4 percent and methyl sulfinyl-2-ethyl sulfonyl ethane, 10.4 percent. Another metabolite accounting for less than 1 percent of the radioactivity in the urine was not further investigated. Treatment of urine with glucuronidase or sulfatase did not indicate the presence of any glucuronide or sulfate conjugates.

来源:Hazardous Substances Data Bank (HSDB)

代谢

代森-S-甲基的主要代谢途径是侧链的氧化，导致相应亚砜（甲氧基代森）的形成，在进一步氧化后，到较小区别，形成磺酰化物。也有O-脱甲基化反应发生。尚未发现葡萄糖苷酸或硫酸盐结合物。

The main metabolic route of demeton-S-methyl is oxidation of the side chain leading to the formation of the corresponding sulfoxide, oxydemeton methyl, and to lesser extent, after further oxidation, the sulfone. O-demethylation also occurs. Neither glucuronide nor sulfate conjugates have been identified.

来源:Hazardous Substances Data Bank (HSDB)

代谢

对农业工作者进行了一项关于有机磷农药尿代谢物的研究。该队列包括40名接触甲基-S-敌百虫的工人。……在开始工作前1天和在工作后12-18小时或2或3天收集尿液样本。他们分析了甲基-S-敌百虫中的二甲基硫代磷酰氧酸钾盐。……使用甲基-S-敌百虫的混合工人在3天工作后二甲基硫代磷酰氧酸钾盐的中位浓度为83 ng/cc。

A study of urinary metabolites of organophosphorus pesticides in agricultural workers was conducted. The cohort consisted of 40 workers exposed to demeton-S-methyl. ...Urine samples were collected 1 day before beginning work and 12-18 hrs or 2 or 3 days after work. They were analyzed for dimethyl-phosphorothiolate-potassium-salt in the case of demeton-S-methyl. ...Median concentration of dimethyl-phosphorothiolate-potassium-salt in mixers using demeton-S-methyl was 83 ng/cc after 3 days work.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

普通人群对代森-S-甲基硫赶的主要暴露来源于食物作物上的残留物。在大鼠体内，代森-S-甲基硫赶从肠道快速且几乎完全吸收，并在体内组织（红细胞中浓度较高）中均匀分布。它在大鼠体内迅速代谢并通过尿液排出。血液中的浓度随着初始半衰期约2小时而降低。处理后24小时，体内大约还有1%的口服剂量。在大鼠中，代森-S-甲基硫赶的主要代谢途径是侧链的氧化，形成相应的亚砜（氧代森-S-甲基硫赶）和更小程度的进一步氧化，形成磺酰化物。另一个重要的代谢途径是O-去甲基化。代森-S-甲基硫赶会导致胆碱能毒性。没有发现增加的发生率。代森-S-甲基硫赶对皮肤和眼睛有轻微的刺激性。在实际使用中，代森-S-甲基硫赶的致敏性不应成为问题。代森-S-甲基硫赶对胚胎无毒性也不会导致畸形。目前可用的信息不足以允许对代森-S-甲基硫赶的基因毒性潜力进行充分评估。代森-S-甲基硫赶既没有引起延迟性多发性神经病也没有抑制神经病靶酯酶。两种植物和哺乳动物代谢物是氧代森-S-甲基硫赶和代森-S-甲基硫赶磺酰化物，这两种化合物的毒理学特性在数量和质量上与代森-S-甲基硫赶没有显著差异。代森-S-甲基硫赶是直接的胆碱酯酶抑制剂，其引起的毒性与其在神经末梢抑制乙酰胆碱酯酶有关。有报道称自杀尝试后出现了几例急性中毒的胆碱能综合症。在包装商业制剂时的不小心职业暴露后，一些工人出现了需要药物治疗胆碱能毒性。代森-S-甲基硫赶的吸收可能是通过皮肤。同样，不当的工作条件可能在棉花田施用代森-S-甲基硫赶时导致过度的皮肤吸收。它对水生无脊椎动物有很高的急性毒性，并对鱼类和鸟类有毒。然而，没有报道说该化合物导致了大量的生物死亡。

Primary exposure for the general human population is from residues of demeton-S-methyl on food crops. ... Demeton-S-methyl is rapidly and almost completely absorbed from the intestinal tract in rats and is uniformly (except for high concentration in erythrocytes) distributed to body tisssues. It is rapidly metabolized and excreted via the urine. Blood concentration decreases with an initial half life of about 2 hr. About 1% of the oral dose is present in the body 24 hr after treatment. The main metabolic pathway of demeton-S-methyl in rats is the oxidation of the side chain leading to the formation of the corresponding sulfoxide (oxydemeton-methyl) and, to a lesser extent, after further oxidation, to the sulfone. Another important metabolic route is O-demethylation. Demeton-S-methyl causes cholinergic toxicity. ... No increased incidence was found ... Demeton-S-methyl is a mild skin and eye irritant. ... Sensitization should not be a problem in the practical use of demeton-S-methyl. ... Demeton-S-methyl was neither embryotoxic nor teratogenic ... The available information is insufficient to permit an adequate assessment of the genotoxic potential of demeton-S-methyl. ... Demeton-S-methyl caused neither delayed polyneuropathy nor inhibition of neuropathy target esterase ... Two plant and mammalian metabolites /are/ oxydemeton-methyl and demeton-S-methylsulfone ... and the toxicological profile of these two compounds does not significantly differ, either quantitatively or qualitatively, from that of demeton-S-methyl. Demeton-S-methyl is a direct cholinesterase inhibitor, and the toxicity it causes is related to inhibition of acetylcholinesterase at nerve terminals. ... A few cases of acute intoxication with cholinergic syndrome, following suicide attempts, have been reported. ... Following careless occupational exposure during packaging of the commercial formulation, some workers developed cholinergic toxicity which required pharmacological treatment. Absorption of demeton-S-methyl was probably through the skin. Similarly, improper working conditions may have caused excessive dermal absorption during application of demeton-S-methyl in cotton fields. ... It has high acute toxicity to aquatic invertebrates and is toxic to fish and birds, ... However, significant field kills of organisms have not been reported for the compound.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A4；不能归类为人类致癌物。

A4; Not classifiable as a human carcinogen.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶、通过皮肤接触以及摄入进入人体。

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 吸入症状

瞳孔收缩，肌肉痉挛，过度流涎。出汗。恶心。呕吐。腹痛。腹泻。昏迷。眩晕。呼吸困难。虚弱。

Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Vomiting. Abdominal cramps. Diarrhoea. Unconsciousness. Dizziness. Laboured breathing. Weakness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

可能被吸收！更多信息请见吸入部分。

MAY BE ABSORBED! Further see Inhalation.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

吸收、分配和排泄

给Sprague-Dawley雄性大鼠单次口服0.1、0.5、5或10 mg / kg或静脉内0.5或1 mg / kg的(14) C-甲基对硫磷。另外，给雌性大鼠单次口服0.5 mg / kg。服用后，测试材料被非常迅速且几乎完全吸收。在服用0.5或5 mg / kg的口服剂量后，大约3个小时内有超过50％的放射性被消除，大约8个小时内有大约90％。在48小时内，尿液中的放射性活性占给药剂量的98-99％。粪便占0.5 -2％，呼出的空气约占0.2％。 2小时后，体内的放射性残留物约占给药剂量的61％（那时已经排出了约39％），24小时后约为1.3％，48小时后约为0.5％，10天后约为0.2％。实验中回收的放射性总量平均为90-100％。排泄物中的回收百分比在很大程度上与剂量水平，给药途径和动物性别无关。消除率与剂量成比例。在另一项实验中，将0.5 mg / kg的(14) C-甲基对硫磷给雄性大鼠十二指肠给药，胆管造口，24小时内胆汁中约有3％的放射性被排出。服用5 mg / kg的测试材料后，血中的放射性活性在约1小时达到高峰。从给药后0至6小时，血液的半衰期计算为约2小时。从6小时到24小时后，半衰期约为6小时，24小时后要长得多。在24小时后，血液中的几乎所有放射性都是由红细胞中的高保留所解释的，红细胞的放射性活性比其他器官和组织高得多，直到10天。与红细胞相比，24小时后的血清水平较低，10天后可以忽略不计。2小时后，各种器官和组织中的放射性分布相对均匀。放射性没有集中在脂肪组织或网状内皮系统（肝，脾，骨髓）中。给药后两天，大多数器官和组织中的放射性（除血液和红细胞外）下降了130倍。在10天，除血液和红细胞外，大多数器官和组织中的放射性几乎无法检测到。在另一项实验中，全身自动放射性摄影证实了先前关于放射性在体内组织中的分布的发现，但也表明松果体，甲状腺和生殖道中的一些腺体（库珀氏腺，精囊，附睾生殖腺）中有一些放射性积聚。

Male Sprague-Dawley rats given single oral doses of 0.1, 0.5, 5 or 10 mg/kg or intravenous doses of 0.5 or 1 mg/kg of (14)C- demeton-S-methyl. Additional female rats were given a single oral dose of 0.5 mg/kg. The test material was very rapidly and nearly completely absorbed following oral administration. More than 50 percent of the administered radioactivity was eliminated in about three hours and approximately 90 percent within about eight hours following an oral dose of 0.5 or 5 mg/kg. Within 48 hours, radio- activity excreted in the urine accounted for 98-99 percent of the administered dose. Feces accounted for 0.5 - 2 percent and exhaled air for about 0.2 percent. Radioactivity remaining in the body was about 61 percent of the administered dose at two hours (about 39 percent having been already excreted at that time), about 1.3 percent at 24 hours, 0.5 percent at 48 hours and 0.2 percent at ten days. Total recovered radioactivity in experiments averaged 90-100 percent. Recovery percentages in excreta were largely independent of dose level, route of administration and sex of the animal. Rates of elimination were dose-proportional. In a separate experiment in which 0.5 mg/kg of (14)C-demeton-S-methyl was intraduodenally administered to male rats with bile duct fistulas, about 3 percent of the administered radioactivity was excreted in the bile within 24 hours. Blood levels of radioactivity peaked at about one hour following oral administration of 5 mg/kg of the test material. From zero to six hours following administration, the blood half-life was calculated to be about two hours. From six to 24 hours post-dosing, the half life was about six hours and after 24 hours it was considerably longer. Nearly all the radioactivity in blood after 24 hours was accounted for by a high retention in erythrocytes which had considerably higher levels of radioactivity than other organs and tissues for up to ten days. Serum levels after 24 hours were low compared to erythrocytes and at ten days were negligible. Distribution of radioactivity in various body organs and tissues was relatively uniform at two hours. Radioactivity did not concentrate in fat tissue or in the reticuloendothelial system (liver, spleen, bone marrow). By two days post-administration, radioactivity in most organs and tissues, except blood and erythrocytes, had dropped 130 fold. At ten days, radioactivity was nearly undetectable in the majority of organs and tissues except for blood and erythrocytes. In a separate experiment, whole-body autoradiography confirmed previous findings regarding distribution of radioactivity in body tissues, but also indicated some localized accumulation or radioactivity in the pineal gland, thyroid and in some glands of the genital tract (Cowper's gland, seminal vescicle, accessory genital gland).

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

Demeton-S-methyl 可通过消化道吸收；通过完好皮肤吸收；以及通过吸入喷雾雾气和粉尘吸收。

Demeton-S-methyl may be absorbed from the gastrointestinal tract; through the intact skin; and by inhalation of spray mist and dusts.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

有机磷农药的皮肤吸收率可能会受到所使用溶剂的影响。

The rate of dermal absorption /of organophosphorus pesticides/ may be ... influenced by the solvent used. /Organophosphorus pesticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

许多有机磷杀虫剂会通过牛奶排出体外... /有机磷杀虫剂/

Many of the organophosphorus insecticides are excreted in the milk ... /Organophosphorus insecticides/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)
• 危险品标志：
  Xn,F,T,N
• 安全说明：
  S16,S26,S28,S36/37,S45,S61
• 危险类别码：
  R20/21/22,R36,R24/25,R11,R51/53
• WGK Germany：
  2
• 海关编码：
  29309090
• 危险品运输编号：
  UN 3018
• RTECS号：
  TG1750000
• 包装等级：
  II
• 危险类别：
  6.1(a)
• 储存条件：
  库房应保持低温、通风和干燥，并与其他食品原料分开存放。

SDS

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模块 1. 化学品
1.1 产品标识符
: 内吸磷-S-甲基 溶液
产品名称
1.2 鉴别的其他方法
无数据资料
1.3 有关的确定了的物质或混合物的用途和建议不适合的用途
仅用于研发。不作为药品、家庭或其它用途。

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模块 2. 危险性概述
2.1 GHS-分类
易燃液体 (类别 2)
急性毒性, 经口 (类别 4)
急性毒性, 吸入 (类别 4)
急性毒性, 经皮 (类别 4)
皮肤刺激 (类别 3)
眼睛刺激 (类别 2A)
2.2 GHS 标记要素，包括预防性的陈述
象形图
警示词 危险
危险申明
H225 高度易燃液体和蒸气
H302 吞咽有害。
H312 皮肤接触有害。
H316 引起轻微皮肤刺激。
H319 造成严重眼刺激。
H332 吸入有害。
警告申明
预防措施
P210 远离热源、火花、明火和热表面。- 禁止吸烟。
P233 保持容器密闭。
P240 容器和接收设备接地。
P241 使用防爆的电气/ 通风/ 照明 设备。
P242 只能使用不产生火花的工具。
P243 采取措施，防止静电放电。
P261 避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾.
P264 操作后彻底清洁皮肤。
P270 使用本产品时不要进食、饮水或吸烟。
P271 只能在室外或通风良好之处使用。
P280 戴防护手套/穿防护服/戴护目镜/戴面罩.
事故响应
P301 + P312 如果吞咽并觉不适: 立即呼叫解毒中心或就医。
P303 + P361 + P353 如果皮肤(或头发)接触：立即除去/脱掉所有沾污的衣物，用水清洗皮肤/淋
浴。
P304 + P340 如吸入: 将患者移到新鲜空气处休息，并保持呼吸舒畅的姿势。
P305 + P351 + P338 如与眼睛接触，用水缓慢温和地冲洗几分钟。如戴隐形眼镜并可方便地取
出，取出隐形眼镜，然后继续冲洗.
P312 如感觉不适，呼救中毒控制中心或医生.
P322 具体处置（见本标签上提供的急救指导）。
P330 漱口。
P332 + P313 如觉皮肤刺激：求医/就诊。
P337 + P313 如仍觉眼睛刺激：求医/就诊。
P363 沾污的衣服清洗后方可再用。
P370 + P378 火灾时： 用干的砂子，干的化学品或耐醇性的泡沫来灭火。
安全储存
P403 + P235 保持低温，存放于通风良好处。
废弃处置
P501 将内容物/ 容器处理到得到批准的废物处理厂。
2.3 其它危害物 - 无

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模块 3. 成分/组成信息
3.2 混合物
: C6H15O3PS2
分子式
: 230.29 g/mol
分子量
组分 分类 浓度或浓度范围
Acetonitrile
-
化学文摘登记号(CA 75-05-8 Flam. Liq. 2; Acute Tox. 4; Eye
S No.) 200-835-2 Irrit. 2A; H225, H302, H312,
EC-编号 608-001-00-3 H319, H332
索引编号 01-2119471307-38-XXXX
注册号
如需在本章节中提及的H类告知和R类描述的全部文字说明,请见第16章节.

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模块 4. 急救措施
4.1 必要的急救措施描述
一般的建议
请教医生。 向到现场的医生出示此安全技术说明书。
吸入
如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。 请教医生。
皮肤接触
用肥皂和大量的水冲洗。 请教医生。
眼睛接触
用大量水彻底冲洗至少15分钟并请教医生。
食入
禁止催吐。 切勿给失去知觉者通过口喂任何东西。 用水漱口。 请教医生。
4.2 主要症状和影响，急性和迟发效应
按氰化物中毒处理。, 总是随身携带附有正确使用说明的氰化物急救包。,
症状的发作一般依赖氰化物的生成而有所延迟。, 恶心, 呕吐, 腹泻, 头痛, 头晕, 皮疹, 发绀, 兴奋, 抑制, 嗜睡,
损害评价, 缺少协调性, 昏迷, 昏迷, 死亡
4.3 及时的医疗处理和所需的特殊处理的说明和指示
无数据资料

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模块 5. 消防措施
5.1 灭火介质
灭火方法及灭火剂
用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。
5.2 源于此物质或混合物的特别的危害
碳氧化物, 氮氧化物, 氢氰酸
5.3 给消防员的建议
如必要的话,戴自给式呼吸器去救火。
5.4 进一步信息
用水喷雾冷却未打开的容器。

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模块 6. 泄露应急处理
6.1 作业人员防护措施、防护装备和应急处置程序
使用个人防护用品。 避免吸入蒸气、烟雾或气体。 保证充分的通风。 移去所有火源。
人员疏散到安全区域。 谨防蒸气积累达到可爆炸的浓度。蒸气能在低洼处积聚。
6.2 环境保护措施
如能确保安全，可采取措施防止进一步的泄漏或溢出。 不要让产品进入下水道。
6.3 泄漏化学品的收容、清除方法及所使用的处置材料
围堵溢出，用防电真空清洁器或湿刷子将溢出物收集起来，并放置到容器中去,根据当地规定处理(见第13部
分)。
6.4 参考其他部分
丢弃处理请参阅第13节。

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模块 7. 操作处置与储存
7.1 安全操作的注意事项
避免接触皮肤和眼睛。 避免吸入蒸气和烟雾。
切勿靠近火源。－严禁烟火。采取措施防止静电积聚。
7.2 安全储存的条件,包括任何不兼容性
贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。
打开了的容器必须仔细重新封口并保持竖放位置以防止泄漏。
建议的贮存温度： 2 - 8 °C
7.3 特定用途
无数据资料

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模块 8. 接触控制和个体防护
8.1 容许浓度
最高容许浓度
组分 化学文摘登 值 容许浓度 基准
记号(CAS
No.)
Aceton