1-[2-[3-(2,2-二苯基乙基)-1,2,4-噁二唑-5-基]乙基]哌啶盐酸盐 | 982-43-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[2-[3-(2,2-二苯基乙基)-1,2,4-噁二唑-5-基]乙基]哌啶盐酸盐
• 英文名称: 1-{2-[3-(2,2-diphenyl-ethyl)-[1,2,4]oxadiazol-5-yl]-ethyl}-piperidine; monohydrochloride
• 英文别名: prenoxdiazine; monohydrochloride；3-(2,2-diphenylethyl)-5-(2-piperidin-1-ylethyl)-1,2,4-oxadiazole;hydron;chloride
• CAS: 982-43-4
• 化学式: C₂₃H₂₇N₃O*ClH
• 分子量: 397.948
• InChiKey: ONTOFAWPPHNLML-UHFFFAOYSA-N

物化性质

• 熔点：
  192-193°
• 密度：
  1.1144 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

文献信息

• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• METHOD OF TREATING A PATHOLOGICAL SYNDROME
  申请人：Epshtein Oleg Iliich

  公开号：US20160229914A1

  公开（公告）日：2016-08-11

  A method of treating disorder or condition that relates to intracellular signal transmission of a neurotransmitter, comprising administration of an homeopathically potentized form of antibodies to an antigen, which antigen is a molecule capable of effecting the intracellular signal transmission of a neuroreceptor, in particular dopamine or serotonin.

  一种治疗与神经递质的细胞内信号传递相关的疾病或症状的方法，包括给予一种高度稀释的抗原抗体制剂，该抗原是一种能够影响神经受体的细胞内信号传递的分子，特别是多巴胺或血清素。
• CURING METHOD FOR PATHOLOGIC SYNDROME AND A MEDICINAL PREPARATION
  申请人：Epshtein, Oleg Iliich

  公开号：EP1295606A1

  公开（公告）日：2003-03-26

  A method of treating a pathological syndrome includes administration of an activated form of ultra-low doses of antibodies to an antigen, wherein said activated form is obtained by repeated consecutive dilution combined with external impact, and the antigen is a substance or a pharmaceutical agent exerting influence upon the mechanisms of formation of this particular pathological syndrome. Pharmaceutical agent for treating a pathological syndrome contains activated form of ultra-low doses of monoclonal, polyclonal or natural antibodies to an antigen, wherein said activated form is prepared by means of repeated consecutive dilution and external treatment, predominantly based on homeopathic technology, and said antigen is a substance or a drug acting as a direct cause of the pathological syndrome or involved in regulation of mechanisms of its formation. At that, activated forms of ultra-low doses of antibodies are raised against antigens of exogenous or endogenous origin, against autologous antigens, fetal antigens; anti-idiotypic antibodies are used too.

  一种治疗病理综合征的方法，包括给药超低剂量抗原抗体的活化形式，其中所述活化形式是通过反复连续稀释结合外部影响获得的，抗原是对该特定病理综合征的形成机制有影响的物质或药剂。 治疗病理综合征的药剂包含超低剂量的抗原单克隆抗体、多克隆抗体或天然抗体的活化形式，其中所述活化形式是通过反复连续稀释和外部处理的方法制备的，主要基于顺势疗法技术，所述抗原是作为病理综合征的直接原因或参与调节其形成机制的物质或药物。在这种情况下，针对外源性或内源性抗原、自体抗原、胎儿抗原的超低剂量抗体活化形式就会产生。
• Compositions for treating pain of the mucous membrane
  申请人：EpiCept Corporation

  公开号：EP1559418A1

  公开（公告）日：2005-08-03

  Compositions useful for long-lasting pain relief from mucosal damage, such as mucosal inflammation, abrasions, ulcerations, lesions, trauma and incisions, without significant systemic absorption. The compositions of the invention are particularly suitable for application to the mucous membrane of the nasal cavity and bucal cavity. To relieve pain, the compositions or the invention are topically applied directly to the affected area.

  本发明的复合物可用于粘膜损伤（如粘膜炎症、擦伤、溃疡、病变、创伤和切口）的持久止痛，且不会被全身大量吸收。本发明的组合物尤其适合用于鼻腔和颊腔粘膜。为缓解疼痛，可将本发明的组合物直接局部涂抹于患处。