1-丁基-2,3-二甲氧基苯 | 82895-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-丁基-2,3-二甲氧基苯
• 英文名称: 1-Butyl-2,3-dimethoxy-benzene
• 英文别名: 1-Butyl-2,3-dimethoxybenzene
• CAS: 82895-27-0
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: TYEIKLOYVMBOAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  正丁基锂 、 o-benzoquinone bis(dimethyl acetal) 生成 1-丁基-2,3-二甲氧基苯
  参考文献：
  名称：

  KIKUCHI, YOSHIYUKI;HASEGAWA, YOKO;MATSUMOTO, MASAKATSU, TETRAHEDRON LETT., 1982, 23, N 21, 2199-2202

  摘要：

  DOI：

文献信息

• TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS
  申请人：AMGEN INC.

  公开号：US20140235642A1

  公开（公告）日：2014-08-21

  Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  式I的化合物可用作TRPM8的拮抗剂。这些化合物对治疗多种TRPM8介导的疾病和症状有用，并可用于制备治疗这些疾病和症状的药物和制剂。这些疾病的例子包括但不限于偏头痛和神经病性疼痛。式I的化合物具有以下结构:其中变量的定义在此提供。
• Reaction of -benzoquinone bisacetals with organolithiums. A novel route to substituted veratroles
  作者：Yoshiyuki Kikuchi、Yoko Hasegawa、Masakatsu Matsumoto

  DOI：10.1016/s0040-4039(00)87299-8

  日期：1982.1
• KIKUTI, SEYUKI;MATSUMOTO, MASAKATSU;XASEHGAVA, JOKO
  作者：KIKUTI, SEYUKI、MATSUMOTO, MASAKATSU、XASEHGAVA, JOKO

  DOI：——

  日期：——
• COMPOSITION AND POLYMER
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP2735581B1

  公开（公告）日：2021-07-14
• DEVELOPMENT OF PHOTOSTABLE NEAR-IR CYANINE DYES FOR IN VIVO IMAGING
  申请人：National University of Singapore

  公开号：US20130101517A1

  公开（公告）日：2013-04-25

  A compound of structural formula (I): The values and alternative values are as defined herein. The invention also includes biosensors comprising nanoparticles functionalized with a compound of structural formula (I). Also described is a method for labeling a biomolecule using a compound of structural formula (I) and a method of detecting a target biomolecule using a compound of structural formula (I) or a biosensor of the invention.