1-氯-2,3,5-三氟-4,6-二异氰酸苯 | 46495-66-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-氯-2,3,5-三氟-4,6-二异氰酸苯
• 英文名称: 1-Chloro-2,3,5-trifluoro-4,6-diisocyanatobenzene
• CAS: 46495-66-3
• 化学式: C₈ClF₃N₂O₂
• 分子量: 248.54
• InChiKey: RDSWPXZXPBCUPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.9
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• IN SITU BULKING COMPOSITION
  申请人：Milbocker Michael T.

  公开号：US20110135700A1

  公开（公告）日：2011-06-09

  The present invention relates to a hydrated, biocompatible tissue-augmentation compound and methodology for its implantation into mammalian tissue. The tissue-augmentation compound is comprised of: living tissue, optionally body derived fluids, and at least one NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate, and oxyethylene-containing diols or polyols in which essentially all of hydroxyl groups are capped with polyisocyanate.

  本发明涉及一种水合的、生物相容的组织增强化合物及其植入哺乳动物组织的方法。该组织增强化合物由活体组织、可选的体液和至少一种由有机多异氰酸酯衍生的NCO-末端亲水性聚氨酯预聚物和含氧乙烯基二醇或多元醇组成，其中基本上所有的羟基都被聚异氰酸酯封顶。
• Fluorinated polyurethanes containing rubber-like polyoxyperfluoroalkylene blocks and rigid blocks
  申请人：AUSIMONT S.p.A.

  公开号：EP0359272A2

  公开（公告）日：1990-03-21

  Polyurethanes comprising rubber-like polyoxyperfluoroalkylene blocks and rigid segments derived from short-chain aliphatic diols and/or aliphatic or aromatic diamines and from (cyclo)aliphatic or aromatic diisocyanates, wherein the number of rigid segments is equal to or higher than the number of rubber-like blocks are described. Said polyurethanes are characterized by a glass transition temperature lower than -80°C, a tensile strength higher that 30 kg/cm² and a hardness of from 50 Shore A to 75 Shore D and show good thermoforming characteristics.

  所述聚氨酯由橡胶状聚全氟烷烃嵌段和刚性段组成，刚性段来源于短链脂肪族二元醇和/或脂肪族或芳香族二元胺以及（环）脂肪族或芳香族二异氰酸酯，其中刚性段的数量等于或高于橡胶状嵌段的数量。这些聚氨酯的特点是玻璃化转变温度低于 -80°C，拉伸强度高于 30 kg/cm²，硬度介于 50 Shore A 到 75 Shore D 之间，并具有良好的热成型特性。
• Fluorinated polyurethanes containing polyoxyperfluoroalkylene blocks
  申请人：AUSIMONT S.r.l.

  公开号：EP0359273A2

  公开（公告）日：1990-03-21

  Polyurethanes comprising rubber-like polyoxyperfluoroalkylene blocks and rigid segments derived from low molecular weight compounds and from (cyclo)aliphatic or aromatic diisocyanates, wherein the number of rigid segments is higher than the number of rubber-like blocks, are described. Said polyurethanes are characterized by a glass transition temperature lower than -80°C, a tensile strength higher than 30 kg/cm² and a hardness of from 50 Shore A to 75 Shore D, and show good thermoforming characteristics.

  描述了由橡胶状聚全氟烷烃嵌段和刚性段组成的聚氨酯，刚性段来自低分子量化合物和（环）脂肪族或芳香族二异氰酸酯，其中刚性段的数量高于橡胶状嵌段的数量。这些聚氨酯的特点是玻璃化转变温度低于 -80°C，拉伸强度高于 30 kg/cm²，硬度从 50 Shore A 到 75 Shore D，并具有良好的热成型特性。
• Crosslinkable polyurethane rubbers containing polyoxyperfluoroalkylene blocks
  申请人：AUSIMONT S.p.A.

  公开号：EP0359271A2

  公开（公告）日：1990-03-21

  Fluorinated polyurethanes containing perfluoropolyether blocks with rubber-like properties, alternating with rigid structural units are described. Said rigid units at least partially are provided with olefinic double bonds suitable for causing a radical-induced crosslinking of the polymeric chains.

  本发明描述了含有具有橡胶特性的全氟聚醚嵌段和刚性结构单元的氟化聚氨酯。所述刚性结构单元至少部分含有烯烃双键，可引起聚合物链的自由基交联。
• Situ bulking device
  申请人：——

  公开号：US20020049363A1

  公开（公告）日：2002-04-25

  The present invention relates to a hydrated, biocompatible tissue-augmentation compound and its methodology for implantation into mammalian tissue. The tissue-augmentation compound is comprised of: living tissue, body derived fluids, at least one NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate, and oxyethylene-based diols or polyols comprised essentially all of hydroxyl groups capped with polyisocyanate

  本发明涉及一种水合生物相容性组织增强化合物及其植入哺乳动物组织的方法。该组织增强化合物由以下成分组成：活组织、机体衍生液体、至少一种由有机多异氰酸酯衍生的 NCO 端亲水聚氨酯预聚物，以及基本上全部由羟基和多异氰酸酯封端的氧乙烯基二元醇或多元醇。