1-烯丙基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶甲腈 | 25855-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 1-烯丙基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶甲腈
• 中文别名: 1-烯丙基-2,4-二氧-1,2,3,4-四氢-5-嘧啶甲腈
• 英文名称: 1-Allyl-5-cyanouracil
• 英文别名: 1-allyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile；1-allyl-2-4-dioxo-1-2-3-4-tetrahydro-5-pyrimidinecarbonitrile；1-Allyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile；2,4-dioxo-1-prop-2-enylpyrimidine-5-carbonitrile
• CAS: 25855-27-0
• 化学式: C₈H₇N₃O₂
• 分子量: 177.162
• InChiKey: LPDJFWOEFJOJMB-UHFFFAOYSA-N

物化性质

• 熔点：
  156-158°C
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  73.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933599090

文献信息

• COMPOUNDS AND METHODS FOR THE TREATMENT OF UBIQUITIN CONJUGATING DISORDERS
  申请人：Hygeia Biological Systems

  公开号：EP1778011A2

  公开（公告）日：2007-05-02
• Compounds and methods for the treatment of ubiquitin conjugating disorders
  申请人：Banerjee Amit

  公开号：US20060035890A1

  公开（公告）日：2006-02-16

  The present invention provides methods for identifying compounds that selectively bind one or more active sites within an ubiquitin conjugating enzyme. The compounds identified by the methods are useful in the treatment of disorders attributed to dysregulated ubiquitin conjugating enzyme function, specifically in hyperproliferative disorders.
• Method for the treatment of a ubiquitin conjugating disorder
  申请人：Banerjee Amit

  公开号：US20070191488A1

  公开（公告）日：2007-08-16

  The present invention provides methods for identifying compounds that selectively bind one or more active sites within an ubiquitin conjugating enzyme. The compounds identified by the methods are useful in the treatment of disorders attributed to dysregulated ubiquitin conjugating enzyme function, specifically in hyperproliferative disorders.
• US8003572B2
  申请人：——

  公开号：US8003572B2

  公开（公告）日：2011-08-23
• [EN] COMPOUNDS AND METHODS FOR THE TREATMENT OF UBIQUITIN CONJUGATING DISORDERS<br/>[FR] COMPOSES ET PROCEDES DESTINES AU TRAITEMENT DES TROUBLES DE CONJUGAISON D'UBIQUITINE
  申请人：HYGEIA BIOLOG SYSTEMS

  公开号：WO2006020681A2

  公开（公告）日：2006-02-23

  The present invention provides methods for identifying compounds that selectively bind one or more active sites within an ubiquitin conjugating enzyme. The compounds identified by the methods are useful in the treatment of disorders attributed to dysregulated ubiquitin conjugating enzyme function, specifically in hyperproliferative disorders.