1-烯丙基-3,7-二甲基-8-苯基黄嘌呤 | 149981-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 1-烯丙基-3,7-二甲基-8-苯基黄嘌呤
• 英文名称: 1-allyl-3,7-dimethyl-8-phenylxanthine
• 英文别名: 3,7-dimethyl-8-phenyl-1-prop-2-enylpurine-2,6-dione
• CAS: 149981-23-7
• 化学式: C₁₆H₁₆N₄O₂
• mdl: MFCD00083166
• 分子量: 296.329
• InChiKey: DKISSNPEWQAXRA-UHFFFAOYSA-N

物化性质

• 熔点：
  173-174°C
• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.187
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙烯酰碘 、 3,7-二甲基-8-苯基黄嘌呤 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以85%的产率得到1-烯丙基-3,7-二甲基-8-苯基黄嘌呤
  参考文献：
  名称：

  Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors

  摘要：

  An aryl p-(trifluoromethyl) substituent increases the affinity of 1,3-disubstituted 8-phenylxanthines at A2a-adenosine receptors, while having little effect on affinity at Al-adenosine receptors. In contrast, an aryl p-(trifluoromethyl) substituent has little effect on affinity of 3,7-disubstituted and 1,3,7-trisubstituted 8-phenylxanthines. An aryl p-sulfo substituent reduces affinity of all 8-phenylxanthines at A1-and A2a-adenosine receptors. An 8-(trifluoromethyl) substituent markedly reduces affinity of 1,3-dialkylxanthines at both A1- and A2a-adenosine receptors. In contrast, 8-(trifluoromethyl)caffeine retains affinity for A2a-adenosine receptors, but does lose affinity for A1-adenosine receptors. 8-Bromo-, 8-acryl-, and 8-pent-1-enylcaffeines are also selective for A2-adenosine receptors, while 8-cyclobutylcaffeine is nonselective. 8-[trans-2-(tert-butyloxycarbonyl)vinylcaffeine is 20-fold selective for Aza vs A1 receptors.

  DOI：

  10.1021/jm00070a007

文献信息

• Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same
  申请人：Takara Bio USA, Inc.

  公开号：US10584363B2

  公开（公告）日：2020-03-10

  Methods of producing single-stranded deoxyribonucleic acids (ssDNAs) are provided. Aspects of the methods include generating a double stranded deoxyribonucleic acid (dsDNA) and then selectively degrading one strand of the dsDNA to produce a ssDNA. ssDNAs produced using methods of the invention find use in a variety of applications, including genomic modification applications. Also provided are compositions, e.g., kits, that find use in practicing various embodiments of the invention.

  本文提供了生产单链脱氧核糖核酸（ssDNA）的方法。 这些方法的各个方面包括产生双链脱氧核糖核酸（dsDNA），然后选择性地降解dsDNA的一条链以产生ssDNA。使用本发明方法产生的ssDNA可用于各种应用，包括基因组修饰应用。 此外，还提供了可用于实施本发明各种实施方案的组合物，如试剂盒。
• Methods for detecting agglutination and compositions for use in practicing the same
  申请人：The Regents of the University of California

  公开号：US11149296B2

  公开（公告）日：2021-10-19

  Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the antigen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided.

  提供了检测样品中抗原结合剂的方法。这些方法的各个方面包括通过与抗原结合的多核苷酸的灵敏近距离结合来检测抗原结合剂与多核苷酸结合抗原的聚集。这些方法的各个方面还包括通过核酸扩增来检测这种基于近距离结合的方法。此外，还提供了有助于实施本方法各实施例的组合物，如试剂、试剂盒和装置。
• Materials and methods for binding nucleic acids to surfaces
  申请人：——

  公开号：US20020103350A1

  公开（公告）日：2002-08-01

  Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By masking the phosphate charges of the nucleic acids, undesired interactions may be minimized or eliminated, thereby allowing the covalent bonding of the nucleic acids to the surface to proceed. The use of such formulations additionally minimizes nonspecific binding of the nucleic acids to the surface. Examples of materials to be included in such formulations include cations, xanthines, hexoses, purines, arginine, lysine, polyarginine, polylysine, and quaternary ammonium salts.

  含有高纯度二氧化硅的表面具有很高的核酸负载潜力。 本研究公开了含有核酸的制剂和可掩盖核酸与表面之间静电相互作用的材料。通过掩盖核酸的磷酸电荷，可以最大限度地减少或消除不希望发生的相互作用，从而使核酸与表面的共价键结合得以进行。此外，使用此类制剂还能最大程度地减少核酸与表面的非特异性结合。可包括在此类制剂中的材料包括阳离子、黄嘌呤、己糖、嘌呤、精氨酸、赖氨酸、多精氨酸、多赖氨酸和季铵盐。
• ADENOSINE AS A POSITIVE INOTROP IN THE COMPROMISED HEART
  申请人：UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER

  公开号：EP0814810A1

  公开（公告）日：1998-01-07
• EP0814810A4
  申请人：——

  公开号：EP0814810A4

  公开（公告）日：1999-06-09