1-甲基二乙烯三胺 | 34066-95-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-甲基二乙烯三胺
• 英文名称: N-methyl-2,2′-diaminodiethylamine
• 英文别名: 1-methyldiethylenetriamine；1,2-Ethanediamine, N-(2-aminoethyl)-N'-methyl-；N'-[2-(methylamino)ethyl]ethane-1,2-diamine
• CAS: 34066-95-0
• 化学式: C₅H₁₅N₃
• mdl: MFCD00039782
• 分子量: 117.194
• InChiKey: QATBRNFTOCXULG-UHFFFAOYSA-N

物化性质

• 沸点：
  199.5±8.0 °C(Predicted)
• 密度：
  0.885±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  对苯二甲醛 、 1-甲基二乙烯三胺 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 48.0h， 以43%的产率得到6,19-Dimethyl-3,6,9,16,19,22-hexaazatricyclo[22.2.2.2<11,14>]triaconta-1(27),11,13,24(28),25,29-hexaene
  参考文献：
  名称：

  通过基于大环的新型双核镍配合物比色和荧光检测水中的草酸盐：荧光带显着红移†

  摘要：

  一种新的基于大环的双核镍化学传感器选择性地结合溶液和固态中的草酸根阴离子，在存在外部染料的情况下，在生理 pH 值的水中显示出显着的荧光带红移和可见的颜色变化。

  DOI：

  10.1039/c3dt53467g

文献信息

• Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
  作者：K. C. Murdock、R. G. Child、P. F. Fabio、Robert D. Angier、Roslyn E. Wallace、Frederick E. Durr、R. V. Citarella

  DOI：10.1021/jm00195a002

  日期：1979.9

  The condensation of alkylenediamines with quinizarin or with 2,3-dihydro-1,4,5,8-tetrahydroxy-9,10-anthracenedione, followed by oxidation, gave 1,4-bis[aminoalkyl)amino]-9,10-anthracenediones. Some of these compounds and their 2,3-dihydro derivatives were markedly active against both leukemias and solid tumors in mice. Activity was maximal with 5,8-dihydroxylation and 1,4-bis[(2-aminoethyl)amino] substitution, in which the terminal nitrogen atoms were either unsubstituted (compound 50) or carried 2-hydroxyethyl groups (compound 40), indicating the importance of hydrophilicity. Against B-16 melanoma, 50 gave greater than 433% increase in median life span (ILS) with 7/10 80-day survivors. Against P-388 leukemia, 40 gave greater than 500% ILS with 4/5.60-day survivors; its efficacy and therapeutic index equaled or surpassed those of adriamycin, cyclophosphamide, daunorubicin, methotrexate, or 5-fluorouracil. Against L-1210 leukemia, B-16 melanoma, and colon tumor 26, 40 was generally as effective or more effective than adriamycin and is now undergoing preclinical toxicological evaluation.
• Colourimetric and fluorescent detection of oxalate in water by a new macrocycle-based dinuclear nickel complex: a remarkable red shift of the fluorescence band
  作者：Md Mhahabubur Rhaman、Frank R. Fronczek、Douglas R. Powell、Md. Alamgir Hossain

  DOI：10.1039/c3dt53467g

  日期：——

  A new macrocycle-based dinuclear nickel chemosensor selectively binds oxalate anions both in solution and the solid state, displaying a remarkable red shift of the fluorescence band with a visible colour change in water at physiological pH in the presence of an external dye.

  一种新的基于大环的双核镍化学传感器选择性地结合溶液和固态中的草酸根阴离子，在存在外部染料的情况下，在生理 pH 值的水中显示出显着的荧光带红移和可见的颜色变化。

表征谱图