1-甲氧基-4-(3-甲基苯氧基)苯 | 82721-04-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-甲氧基-4-(3-甲基苯氧基)苯
• 英文名称: 1-methoxy-4-m-tolyloxybenzene
• 英文别名: 1-(4-methoxyphenoxy)-3-methylbenzene；p-(m-Tolyloxy)anisole；1-methoxy-4-(3-methylphenoxy)benzene
• CAS: 82721-04-8
• 化学式: C₁₄H₁₄O₂
• 分子量: 214.264
• InChiKey: NCTBMVAIKUNJFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-甲氧基-4-(3-甲基苯氧基)苯 在 chromium(VI) oxide 作用下， 生成 3-(4-甲氧基苯氧基)苯甲酸
  参考文献：
  名称：

  Methoxy (and Hydroxy) Phenoxybenzoic Acids

  摘要：

  DOI：

  10.1021/jo50002a021
• 作为产物：
  描述：

  3-(4-甲氧基苯氧基)苯甲醛 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 1.5h， 以95%的产率得到1-甲氧基-4-(3-甲基苯氧基)苯
  参考文献：
  名称：

  A solvent-controlled highly efficient Pd–C catalyzed hydrogenolysis of benzaldehydes to methylbenzenes via a novel ‘acetal pathway’

  摘要：

  Pd-C catalyzed hydrogenolysis of benzaldehydes to methylbenzenes has been described to proceed via a 'benzenemethanol pathway'. In this article, a novel 'acetal pathway' was first revealed by a systematic study when lower alcohols were used as solvents and a solvent-controlled highly efficient procedure was established. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.06.105

文献信息

• Pd-Catalyzed Etherification of Nitroarenes
  作者：Naoki Matsushita、Myuto Kashihara、Michele Formica、Yoshiaki Nakao

  DOI：10.1021/acs.organomet.1c00183

  日期：2021.7.26

  The Pd-catalyzed etherification of nitroarenes with arenols has been achieved using a new rationally designed ligand. Mechanistic insights were used to design the ligand so that both the oxidative addition and reductive elimination steps of a plausible catalytic cycle were facilitated. The catalytic system established here provides direct access to a range of unsymmetrical diaryl ethers from nitroarenes

  使用一种新的合理设计的配体已经实现了 Pd 催化的硝基芳烃与芳醇的醚化。机械见解用于设计配体，以便促进合理催化循环的氧化加成和还原消除步骤。这里建立的催化系统提供了从硝基芳烃中直接获得一系列不对称二芳基醚的途径。
• 1,1,1-Tris(hydroxymethyl)ethane as a New, Efficient, and Versatile Tripod Ligand for Copper-Catalyzed Cross-Coupling Reactions of Aryl Iodides with Amides, Thiols, and Phenols
  作者：Yao-Jung Chen、Hsin-Hung Chen

  DOI：10.1021/ol062339h

  日期：2006.11.1

  1,1,1-tris(hydroxymethyl)ethane was presented as a new, efficient, and versatile tridentate O-donor ligand suitable for the copper-catalyzed formation of C-N, C-S, and C-O bonds. This inexpensive and commercially available tripod ligand has been demonstrated to facilitate the copper-catalyzed cross-coupling reactions of aryl iodides with amides, thiols, and phenols to afford the corresponding desired

  1,1,1-三（羟甲基）乙烷是一种新型，高效，通用的三齿O型供体配体，适用于铜催化的CN，CS和CO键的形成。已经证明这种便宜的和可商购的三脚架配体可以促进芳基碘化物与酰胺，硫醇和酚的铜催化的交叉偶联反应，从而以良好或优异的收率提供相应的所需产物。[反应：请参见文字]。
• <i>N</i>,<i>N</i>-Dimethyl Glycine-Promoted Ullmann Coupling Reaction of Phenols and Aryl Halides
  作者：Dawei Ma、Qian Cai

  DOI：10.1021/ol0350947

  日期：2003.10.1

  [reaction: see text] Ullmann-type diaryl ether synthesis can be performed at 90 degrees C using either aryl iodides or aryl bromides as the substrates under the assistance of N,N-dimethylglycine.

  [反应：见正文] Ullmann型二芳基醚的合成可以在N，N-二甲基甘氨酸的帮助下，使用芳基碘化物或芳基溴化物作为底物，在90摄氏度下进行。
• Carbamic acid esters and use as pesticides
  申请人：Hoffmann-La Roche Inc.

  公开号：US04413010A1

  公开（公告）日：1983-11-01

  Carbamic acid compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X and Y are as hereinafter set forth, processes for their preparation, pesticidal compositions containing one or more of the carbamic acid compounds as the active ingredient and methods for using the pesticidal compositions for the control of pests, particularly insects, mites and nematodes, are described.

  本文描述了化学式为##STR1##的碳酸化合物，其中R.sup.1，R.sup.2，R.sup.3，R.sup.4，R.sup.5，R.sup.6，X和Y如下所述，以及它们的制备过程、含有一种或多种碳酸化合物作为活性成分的杀虫剂组合物和使用这些杀虫剂组合物控制害虫，特别是昆虫、螨和线虫的方法。
• Low Catalyst Loadings for Copper-Catalyzed O-Arylation of Phenols with Aryl and Heteroaryl Halides under Mild Conditions
  作者：Yong-Chua Teo、Fui-Fong Yong、Yaw-Kai Yan、Guan-Leong Chua

  DOI：10.1055/s-0031-1290110

  日期：2012.1

  A practical and mild strategy has been developed for the cross-coupling of O-arylation of phenol with differently substituted aryl halides and heteroaryl iodides using low catalyst loading of copper iodide under low operating temperature in DMF with TMHD as the ligand and Cs2CO3 as the base. This method tolerates a variety of functional groups including sterically hindered phenols and heteroaryl iodides

  已经开发了一种实用且温和的策略，用于在 DMF 中以 TMHD 为配体和 Cs2CO3 为碱，在低操作温度下，使用低催化剂负载量的碘化铜将苯酚与不同取代的芳基卤化物和杂芳基碘化物的 O-芳基化交叉偶联. 该方法可耐受各种官能团，包括空间位阻酚和杂芳基碘化物，以提供良好至极好的产率（高达 95%）的产品。