1-羟基-10H-吩噻嗪 | 7445-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 1-羟基-10H-吩噻嗪
• 英文名称: 1-hydroxy-10H-phenothiazine
• 英文别名: 1-hydroxyphenothiazine；10H-phenothiazin-1-ol；phenothiazin-1-ol；4-Hydroxy-phenothiazin；10H-Phenothiazin-1-ol
• CAS: 7445-99-0
• 化学式: C₁₂H₉NOS
• 分子量: 215.276
• InChiKey: DKYSJQNSWGHPKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-羟基-10H-吩噻嗪 在 lead dioxide 作用下， 生成 phenothiazin-1-one
  参考文献：
  名称：

  1H - phenothiazin - 1 - ones, a new class of heterocyclic -quinoneimines

  摘要：

  DOI：

  10.1016/s0040-4039(01)92013-1
• 作为产物：
  描述：

  1-甲氧基-10H-吩噻嗪 在 吡啶盐酸盐 作用下， 生成 1-羟基-10H-吩噻嗪
  参考文献：
  名称：

  Notes- Ring Derivatives of Phenothiazine. IV. Further Studies on the Thionation Reaction, and the Synthesis of Phenothiazinols

  摘要：

  DOI：

  10.1021/jo01089a600

文献信息

• NOVEL SPIROOXYINDOLE COMPOUNDS AND DRUGS CONTAINING SAME
  申请人：NAKASHIMA Hisashi

  公开号：US20080306102A1

  公开（公告）日：2008-12-11

  A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11β-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11β-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).

  本发明的化合物或其盐，或其溶剂化物，由下式（1）表示的螺环氧吲哚化合物，显示出对11β-羟基类固醇脱氢酶的优越抑制作用，并且可用作预防或治疗涉及11β-羟基类固醇脱氢酶的疾病的药剂（特别是糖尿病、胰岛素抵抗、糖尿病并发症、肥胖、血脂异常、高血压、脂肪肝或代谢综合征）。
• Novel physiologically active substances
  申请人：Kotake Yoshihiko

  公开号：US20050245514A1

  公开（公告）日：2005-11-03

  Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents and R 3 , R 7 , R 16 , R 17 , R 20 , R 21 and R 21′ are the same or different and each represents hydrogen, etc. Because of inhibiting angiogenesis and inhibiting the production of VEGF particularly in hypoxia, the compounds (I) are useful as remedies for solid cancer.

  具有下述通式(I)表示的化合物、其药理学上可接受的盐或水合物：(I)其中W代表，R3、R7、R16、R17、R20、R21及R21'相同或不同，各自代表氢等。由于能抑制血管生成及在缺氧条件下抑制VEGF的产生，化合物(I)可作为实体癌症的治疗药物。
• Heterocyclic compound having oxime group
  申请人：Yoshida Ichiro

  公开号：US20050227959A1

  公开（公告）日：2005-10-13

  The present invention provides a compound that has an excellent inhibitory activity on STAT6 activation and is effective against allergic diseases, and a medicinal composition thereof. According to the present invention, disclosed is the compound represented by the General Formula (I) [where R 1 and R 2 independently represent a C 1-6 alkyl group and the like that may have a hydrogen atom or a substituent; R 3 represents a C 1-6 alkyl group and the like that may have a substituent; R 4 and R 5 independent represents a hydrogen atom or a C 1-6 alkyl group and the like that may have a substituent; R 6 represents a hydrogen atom and the like; W represents —SO 2 — and the like; and X represents a sulphur atom and the like.]or a salt thereof, or a hydrate thereof.

  本发明提供了一种对STAT6激活具有优异抑制活性且对过敏疾病有效的化合物及其药物组合物。根据本发明，公开了由通式（I）表示的化合物[其中R1和R2独立地表示可能具有氢原子或取代基等的C1-6烷基基团；R3表示可能具有取代基的C1-6烷基基团等；R4和R5独立地表示可能具有取代基的氢原子或C1-6烷基基团等；R6表示氢原子等；W表示—SO2—等；X表示硫原子等]或其盐或水合物。
• Antioxidant Activities of Phenothiazines and Related Compounds: Correlation between the Antioxidant Activities and Dissociation Energies of O–H or N–H Bonds
  作者：Tatsuo Yamamura、Kyouichi Suzuki、Tatsuya Yamaguchi、Tomihiro Nishiyama

  DOI：10.1246/bcsj.70.413

  日期：1997.2

  The antioxidant activities of phenothiazines, carbazoles, and related diphenylamines were evaluated in the oxidation of tetralin at 60 °C and linoleic acid micelles in aqueous dispersion at 37 °C induced by an azo initiator. Phenothiazines were highly antioxidant in both systems. Although diphenylamine and carbazole were not good antioxidants, those having a hydroxy group as a substituent at the ortho

  吩噻嗪、咔唑和相关二苯胺的抗氧化活性在由偶氮引发剂诱导的 60°C 萘满和 37°C 水分散体中的亚油酸胶束氧化中进行评估。吩噻嗪在两个系统中都具有很强的抗氧化性。尽管二苯胺和咔唑不是很好的抗氧化剂，但那些在氨基的邻位或对位具有羟基取代基的化合物是有效的抗氧化剂。由于苯氧基自由基的稳定性，邻羟基二苯胺的抗氧化活性比两个系统中的其他化合物都要大得多，这是因为未配对电子离域到氨基的 p 型孤对电子。应用半经验MNDO-AM1计算来研究自氧化链式过程中抗氧化剂的夺氢。
• TARGET MOLECULES OF PLADIENOLIDES, COMPOUNDS BINDING TO SUCH TARGET MOLECULES, AND SCREENING METHOD THEREOF
  申请人：Kotake Yoshihiko

  公开号：US20090227795A1

  公开（公告）日：2009-09-10

  A method of measuring the binding activity of a test compound to a splicing factor 3 b (SF3 b ), which comprises the following steps of: (a) contacting a labeled pladienolide compound and a test compound with a cell or a cell fraction; and (b) measuring the distribution of the bound labeled compound. The method enables to screen for a novel active compound capable of acting on (binding to) a pladienolide target molecule or the like.

  一种测量试验化合物与剪接因子3b（SF3b）结合活性的方法，包括以下步骤：(a)将标记的普拉地诺酯化合物和试验化合物与细胞或细胞分离物接触；(b)测量结合的标记化合物的分布。该方法能够筛选出能够作用于（结合到）普拉地诺酯靶分子或类似分子的新型活性化合物。