1-苯乙基-哌嗪双盐酸盐 | 5321-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-苯乙基-哌嗪双盐酸盐
• 中文别名: 1-苯乙基哌嗪二盐酸盐
• 英文名称: 1-Phenethyl-piperazine dihydrochloride
• 英文别名: 1-(2-phenylethyl)piperazine;dihydrochloride
• CAS: 5321-62-0
• 化学式: C12H20Cl2N2
• 分子量: 263.2
• InChiKey: JWSRGCWCXUCWBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.98
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.3
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  1-苯乙基-哌嗪双盐酸盐 、 二聚氰胺 以70%的产率得到
  参考文献：
  名称：

  ZIKOLOVA, S.;SLAVOVA, S.;XADZHIEVA, K., TR. N.-I. XIM.-FARM. IN-T, NRB, 1985, 15, 13-20

  摘要：

  DOI：

文献信息

• 1, 2, 4-Thiadiazol-5-Ylpiperazine derivatives useful in the treatment of neurodegenerative diseases
  申请人：Griffioen Gerard

  公开号：US20140128404A1

  公开（公告）日：2014-05-08

  The present invention relates to a compound of formula (IA) The present invention also relates to the use of the compound of formula IA for treating certain neurodegenerative disorders characterized by cytotoxic TAU misfolding and/or aggregation.

  本发明涉及一种化合物的公式（IA）。本发明还涉及利用公式IA化合物治疗由细胞毒性TAU错误折叠和/或聚集特征的某些神经退行性疾病。
• [EN] 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES<br/>[FR] DÉRIVÉS DE 1,2,4-THIADIAZOL-5-YLPIPÉRAZINE UTILES DANS LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：REMYND NV

  公开号：WO2013004642A1

  公开（公告）日：2013-01-10

  The present invention relates to a compound of formula (IA) The present invention also relates to the use of the compound of formula IA for treating certain neurodegenerative disorders characterized by cytotoxic TAU misfolding and/or aggregation.

  本发明涉及一种化合物，其化学式为（IA）。本发明还涉及利用化合物IA治疗某些以细胞毒性TAU错误折叠和/或聚集为特征的神经退行性疾病。
• Aralkyl-alcohol peiperazine derivatives adn their uses as antidepressant
  申请人：Li Jianqi

  公开号：US20050267121A1

  公开（公告）日：2005-12-01

  Aryl alkanol piperazine derivatives of the formula and pharmaceutical compositions comprising the same. Also disclosed are methods for treating depression using the pharmaceutical compositon. Compounds of the invention have excellent dual inhibitory actions to the uptake of the mono-amines neurotransmitter, good antidepressant activities and minor side effects.

  Aryl alkanol piperazine衍生物的公式和包含它们的药物组合物。还公开了使用药物组合物治疗抑郁症的方法。本发明的化合物对单胺类神经递质的摄取具有优良的双重抑制作用，具有良好的抗抑郁活性和较小的副作用。
• Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent
  申请人：Li Jianqi

  公开号：US20060148811A1

  公开（公告）日：2006-07-06

  Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also dislcosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.

  Arylalkyl酮哌嗪衍生物的公式为： 以及包含该化合物的药物组合物。还公开了将化合物用作镇痛和镇静剂的方法。本发明的化合物具有良好的镇痛和镇静活性，但副作用很少。
• UREA COMPOUND OR SALT THEREOF
  申请人：Ishii Takahiro

  公开号：US20110172230A1

  公开（公告）日：2011-07-14

  [Object] To provide a compound which can be used for the treatment of a disease associated with fatty acid amide hydrolase (FAAH), particularly urinary frequency, urinary incontinence and/or overactive bladder. [Means for solution] It is confirmed that a urea compound chemical-structurally characterized by having a piperidine or piperazine ring or a salt thereof has an excellent FAAH-inhibitory activity, and thus the present invention is completed. The urea compound or its pharmaceutically acceptable salt of the present invention can increase the effective bladder capacity and ameliorate the state of urinary frequency, and is therefore useful as an agent for treating urinary frequency, urinary incontinence and/or overactive bladder.

  [目的] 提供一种化合物，可用于治疗与脂肪酸酰胺水解酶（FAAH）相关的疾病，特别是尿频、尿失禁和/或膀胱过度活动。 [解决方案] 确认具有哌啶或哌嗪环或其盐的尿素化合物在化学结构上具有出色的FAAH抑制活性，因此完成了本发明。本发明的尿素化合物或其药学上可接受的盐可以增加有效膀胱容量，改善尿频状态，因此可用作治疗尿频、尿失禁和/或膀胱过度活动的药物。