10-(2-甲基丙基)吩噻嗪 | 68825-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 10-(2-甲基丙基)吩噻嗪
• 英文名称: 10-isobutylphenothiazine
• 英文别名: N-isobutylphenothiazine；10-isobutyl-10H-phenothiazine；10-(2-Methylpropyl)-10H-phenothiazine；10-(2-methylpropyl)phenothiazine
• CAS: 68825-24-1
• 化学式: C₁₆H₁₇NS
• 分子量: 255.384
• InChiKey: FESTYMZLGOLYMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-(2-甲基丙基)吩噻嗪 在 potassium permanganate 、 十六烷基三甲基氯化铵 作用下， 以 氯仿 为溶剂， 以93%的产率得到10-Isobutyl-10H-phenothiazine 5,5-dioxide
  参考文献：
  名称：

  制备 N- 烷基吩噻嗪亚砜和砜的选择性氧化方法

  摘要：

  DOI：

  10.1515/hc.2001.7.3.277
• 作为产物：
  描述：

  吩噻嗪 、 溴代异丁烷 在 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 3.33h， 以78%的产率得到10-(2-甲基丙基)吩噻嗪
  参考文献：
  名称：

  超声辅助合成咔唑，吲哚和吩噻嗪的N-烷基衍生物

  摘要：

  咔唑，吲哚和吩噻嗪等带有氮原子的酸性氢原子杂环化合物可以在氢氧化钾为碱的情况下，在DMSO或N，N -DMF中有效地烷基化。在几乎所有情况下，都会大大缩短反应时间，并明显提高产率，同时提高产品质量。

  DOI：

  10.1002/jhet.1652

文献信息

• Zimova, Nad'a; Nemec, Ivan; Ehlova, Miroslava, Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 1, p. 63 - 71
  作者：Zimova, Nad'a、Nemec, Ivan、Ehlova, Miroslava、Waisser, Karel

  DOI：——

  日期：——
• Soft tissue implants and drug combination compositions, and use thereof
  申请人：Hunter L. William

  公开号：US20070196421A1

  公开（公告）日：2007-08-23

  Soft tissue implants (e.g., breast, pectoral, chin, facial, lip, and nasal implants) are used in combination with an anti-scarring drug combination in order to inhibit scarring that may otherwise occur when the implant is placed within an animal.
• Anti-scarring drug combinations and use thereof
  申请人：Hunter L. William

  公开号：US20070208134A1

  公开（公告）日：2007-09-06

  The present invention provides devices or implants that comprise anti-scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fibrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
• Implantable sensors, implantable pumps and anti-scarring drug combinations
  申请人：Hunter L. William

  公开号：US20070197957A1

  公开（公告）日：2007-08-23

  Pumps and sensors for contact with tissue are used in combination with an anti-scarring agent or a composition that comprises an anti-scarring agent to inhibit scarring that may otherwise occur when the pumps and sensors are implanted within an animal.
• Electrical devices and anti-scarring drug combinations
  申请人：Hunter L. William

  公开号：US20070198063A1

  公开（公告）日：2007-08-23

  Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring drug combination or a composition that comprises an anti-scarring drug combination to inhibit scarring that may otherwise occur when the devices are implanted within an animal.