10H-吩噻嗪-2-羧酸酰胺 | 1778-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 10H-吩噻嗪-2-羧酸酰胺
• 中文别名: 氰美马嗪杂质4
• 英文名称: phenothiazine-2-carboxamide
• 英文别名: Phenothiazin-2-carbonsaeure-amid；2-Carbamoyl-phenothiazin；10H-phenothiazine-2-carboxylic acid amide；10H-phenothiazine-2-carboxamide
• CAS: 1778-82-1
• 化学式: C₁₃H₁₀N₂OS
• 分子量: 242.301
• InChiKey: KETFITVSYVFHLU-UHFFFAOYSA-N

物化性质

• 熔点：
  264-265 °C
• 沸点：
  455.7±34.0 °C(Predicted)
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  10H-吩噻嗪-2-羧酸酰胺 在 三氯氧磷 作用下， 生成 氰美马嗪
  参考文献：
  名称：

  Synthesis of Phenothiazines. VI. Certain 2-Substituted Phenothiazines and Their 10-Aminoalkyl Derivatives

  摘要：

  DOI：

  10.1021/jo01063a040
• 作为产物：
  描述：

  10H-吩噻嗪-2-羧酸 生成 10H-吩噻嗪-2-羧酸酰胺
  参考文献：
  名称：

  Synthesis of Phenothiazines. VI. Certain 2-Substituted Phenothiazines and Their 10-Aminoalkyl Derivatives

  摘要：

  DOI：

  10.1021/jo01063a040

文献信息

• Dendrimers as molecular translocators
  申请人：Goodman Murray

  公开号：US20060216265A1

  公开（公告）日：2006-09-28

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  转运分子包括一种树枝状聚合物和一种生物活性分子。这些转运分子的树枝状聚合物包括至少一个胍基团、至少一个质子化的胍基团、至少一个保护的胍基团、至少一个酰胺基团、至少一个质子化的酰胺基团、至少一个保护的酰胺基团、至少一个脲基团、至少一个质子化的脲基团、至少一个保护的脲基团、至少一个硫脲基团、至少一个质子化的硫脲基团，或至少一个保护的硫脲基团。生物活性分子与树枝状聚合物结合。一种增加药物生物利用度的方法包括将药物与本发明的树枝状聚合物结合。
• An Inhibitor of the Interaction of Survivin with Smac in Mitochondria Promotes Apoptosis
  作者：Seong‐Hyun Park、Insu Shin、Sang‐Hyun Park、Nam Doo Kim、Injae Shin

  DOI：10.1002/asia.201900587

  日期：2019.11.18

  Herein we report the first small molecule that disrupts the survivin-Smac interaction taking place in mitochondria. The inhibitor, PZ-6-QN, was identified by initially screening a phenothiazine library using a fluorescence anisotropy assay and then conducting a structure-activity relationship study. Mutagenesis and molecular docking studies suggest that PZ-6-QN binds to survivin similarly to the known

  在此，我们报道了第一个破坏线粒体中survivin-Smac相互作用的小分子。通过首先使用荧光各向异性测定法筛选吩噻嗪文库，然后进行结构-活性关系研究，鉴定了抑制剂PZ-6-QN。诱变和分子对接研究表明，PZ-6-QN与survivin的结合类似于已知的Smac肽AVPI。努力的结果还表明，PZ-6-QN对各种癌细胞表现出良好的抗癌活性。此外，基于细胞的机理研究为PZ-6-QN进入线粒体以抑制survivin-Smac相互作用并促进Smac和细胞色素c从线粒体释放到胞质溶胶中这一提议提供了证据，这一过程诱导了癌细胞的凋亡。全面的，
• Efficient and Regioselective Synthesis of Phenothiazine via Ferric Citrate Catalyzed C-S/C-N Cross-Coupling
  作者：Tonmoy Chitta Das、Syed Aziz Imam Quadri、Mazahar Farooqui

  DOI：10.2174/1570178615666180806114523

  日期：2018.12.4

  Efficient C-S and C-N cross-coupling reactions have been developed for regioselective, scalable and environmentally benign synthesis of substituted phenothiazine derivatives. Cross-coupling reactions were demonstrated on various challenging substrates using non-toxic, highly economical, readily available ferric citrate as a catalyst to get desired product with high regioselectivity. Atom economy is

  已经开发出有效的CS和CN交叉偶联反应，用于取代的吩噻嗪衍生物的区域选择性，可扩展性和环境友好的合成。使用无毒，经济性强，易得的柠檬酸铁作为催化剂，可以在各种具有挑战性的底物上进行交叉偶联反应，从而获得具有高区域选择性的所需产物。原子经济性是该协议的另一个优点，因为不需要在耦合之前进行额外的N保护步骤以及最终对其进行脱保护以获得所需产品的步骤。据我们所知，这是关于使用廉价的柠檬酸铁作为催化剂而不涉及任何配体来合成区域选择性取代的吩噻嗪的报道。
• Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
  申请人：Medinox, Inc.

  公开号：US20030181495A1

  公开（公告）日：2003-09-25

  The present invention provides novel combinations of dithiocarbamate disulfide dimers with other active agents. In one method, the disulfide derivative of a dithiocarbamate is coadministered with a thiazolidinedione for the treatment of diabetes. In another embodiment, In another embodiment, invention combinations further comprise additional active agents such as, for example, metformin, insulin, sulfonylureas, and the like. In another embodiment, the present invention relates to compositions and formulations useful in such therapeutic methods.

  本发明提供了二硫代氨基甲酸盐二硫化二聚体与其他活性药剂的新组合。在一种方法中，二硫代氨基甲酸盐的二硫化衍生物与噻唑烷二酮联合用于治疗糖尿病。在另一实施例中，该发明的组合进一步包括额外的活性药剂，例如二甲双胍、胰岛素、磺酰脲类药物等。在另一实施例中，本发明涉及用于这种治疗方法的组合物和配方。
• COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT
  申请人：Pignol Bernadette

  公开号：US20090149430A1

  公开（公告）日：2009-06-11

  The present invention relates to a composition containing at least one amidine derivative or carboxamide derivative of general formula (I) or (A) in combination with at least one compound chosen from steroids, corticoids or corticosteroids, wherein said composition is suitable for the preparation of a medicament.

  本发明涉及一种含有至少一种氨基甲酸酰胺衍生物或一般式(I)或(A)的羧酰胺衍生物的组合物，与至少一种来自类固醇、皮质类固醇或皮质类固醇的化合物结合在一起，所述组合物适用于制备药物。