1H-苯并[D][1,2,3]三唑-1-基碳酸苄酯 | 59577-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1H-苯并[D][1,2,3]三唑-1-基碳酸苄酯
• 英文名称: 1-benzyloxycarbonyloxy-1H-benzotriazole
• 英文别名: 1-benzyloxycarbonyloxy-1H-benzotriazole；BtO-Cbz；1H-Benzo[d][1,2,3]triazol-1-yl benzyl carbonate；benzotriazol-1-yl benzyl carbonate
• CAS: 59577-41-2
• 化学式: C₁₄H₁₁N₃O₃
• 分子量: 269.26
• InChiKey: UARDXIXWKAZPPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1H-苯并[D][1,2,3]三唑-1-基碳酸苄酯 在 acylase I (Fluka) ammonium hydroxide 、 cobalt(II) acetate 、 三乙胺 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 25.83h， 生成 (E)-N^δ-Z-3,4-didehydro-L-ornithine
  参考文献：
  名称：

  Havlicek, Libor; Hanus, Jan; Nemecek, Jan, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 12, p. 3381 - 3386

  摘要：

  DOI：
• 作为产物：
  描述：

  1-羟基苯并三唑 、 氯甲酸苄酯 在 三乙胺 作用下， 以 水 、 苯 为溶剂， 生成 1H-苯并[D][1,2,3]三唑-1-基碳酸苄酯
  参考文献：
  名称：

  Oxime carbonates

  摘要：

  揭示了一种新型的碳酸酯，可用于在氨基和/或亚氨基化合物中引入酯化羧基型保护基的过程，以临时保护所述氨基和/或亚氨基。此外，还揭示了制备所述酯的方法。

  公开号：

  US04014915A1

文献信息

• Carbonic acid esters, and the preparation thereof and their use
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04010178A1

  公开（公告）日：1977-03-01

  Carbonic acid esters of the formula substituent(s) substituents(s) R'.sub.1 OCOOR'.sub.2 wherein R'.sub.1 is lower alkyl which may have substituent)s) selected from the group of halogen, lower alkoxy and aryloxy, or ar(lower)-alkyl which may have substituents)s) selected from the group of lower alkoxy, halogen, nitro and cyano, and R'.sub.2 is benzotriazolyl which may have halogen; or a group represented by the formula: ##STR1## wherein Y' and Z' are each cyano, nitro, carbamoyl, esterified carboxy, lower alkanoyl, aroyl or disubstituted carbamoyl; provided that when R'.sub.2 is a group represented by the formula: ##STR2## wherein Y' and Z' are each cyano, nitro, carbamoyl or esterified carboxy, R'.sub.1 is ar(lower) alkyl having substituent(s) selected from the group of lower alkoxy, halogen, nitro and cyano. A process for the protection of amino and/or imino groups in compounds containing them by reacting them with the aforementioned esters is also disclosed.

  公式中的碳酸酯基团R'.sub.1 OCOOR'.sub.2，其中R'.sub.1是较低的烷基，可能具有来自卤素、较低的烷氧基和芳基的基团，或者是芳基-较低烷基，可能具有来自较低烷氧基、卤素、硝基和氰基的基团；R'.sub.2是苯并三唑基，可能具有卤素；或者是由以下公式表示的基团：##STR1## 其中Y'和Z'分别是氰基、硝基、氨基甲酰基、酯化羧基、较低的烷酰基、芳酰基或二取代的氨基甲酰基；但是当R'.sub.2是由以下公式表示的基团时：##STR2## 其中Y'和Z'分别是氰基、硝基、氨基甲酰基或酯化羧基时，R'.sub.1是芳基-较低烷基，具有来自较低烷氧基、卤素、硝基和氰基的基团。还公开了一种通过将含有氨基和/或亚氨基基团的化合物与上述酯反应来保护它们的方法。
• Synthesis of Modified Tripeptides and Tetrapeptides as potential bisubstrate inhibitors of the epidermal growth factor receptor protein tyrosine kinase
  作者：Gérard Rossé、Urs Séquin、Helmut Mett、Pascal Furet、Peter Traxler、Heinz Fretz

  DOI：10.1002/hlca.19970800304

  日期：1997.5.12

  The synthesis of a series of bisubstrate inhibitors of the epidermal growth factor receptor protein kinase (EGF-R PTK) consisting of small pep tides linked covalently to adenosine via appropriate triphosphate substitutes is described. Boc-Glu(OtBu)-Tyr-Leu-OBzl (5) and Ac-Glu(OtBu)-Tyr-Leu-Arg(Pmc)-NH2 (8; Pmc = 2,2,5,7,8-pentamethylchroman-6-sulfonyl) were prepared by standard peptide chemistry, (Scheme

  描述了一系列的表皮生长因子受体蛋白激酶（EGF-R PTK）的双底物抑制剂的合成，这些抑制剂由通过适当的三磷酸酯替代物与腺苷共价连接的小肽组成。Boc-Glu（O t Bu）-Tyr-Leu-OBzl（5）和Ac-Glu（O t Bu）-Tyr-Leu-Arg（Pmc）-NH 2（8 ; Pmc = 2,2,5,7通过标准的肽化学制备（8-五甲基苯并吡喃-6-磺酰基）（方案1），然后用己二酸酐或4-（氯磺酰基）苯甲酸，4-（氯磺酰基）-2在酪氨酸的OH基上进行修饰。 -羟基苯甲酸或苯-1,4-二磺酰二氯（方案2），最后与2'，3'- O-异丙基亚氨腺苷的5'-OH基偶联（方案3）。另外，将ATP替代物N 6 -[（苄氧基）羰基] -2'，3' - O-异亚丙基-腺苷5'-（己二酸氢二乙酯）（26）与5的吗啉化物偶联（方案4）。除去保护基得到双底物类似物23、24和28。测试了合成的化合物作为EGF-R
• Compact floribunda rose plant named ‘Poulpal077’
  申请人：Olesen Mogens Nyegaard

  公开号：USPP030752P3

  公开（公告）日：2019-07-30

  A new garden rose plant of the Compact Floribunda class which has abundant, pink flowers and attractive foliage. This new and distinct variety has shown to be uniform and stable in the resulting generations from asexual propagation.

  一种新的紧凑型多花蔷薇植物，拥有丰富的粉色花朵和吸引人的叶子。这个新的独特品种已经证明在无性繁殖的后代中是均匀和稳定的。
• Process for protecting amino and/or imino groups
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04083848A1

  公开（公告）日：1978-04-11

  Novel carbonic acid esters are disclosed which are useful in a process for introducing esterified carboxy-type protective groups on amino and/or imino groups in amino and/or imino group - containing compounds for the temporary protection of said amino and/or imino groups. Additionally, processes for preparing said esters are also disclosed.

  本发明揭示了一种新型的碳酸酯，可用于在含有氨基和/或亚氨基的化合物中引入酯化羧基型保护基的过程中，对所述氨基和/或亚氨基进行暂时保护。此外，本发明还揭示了制备所述酯的方法。
• CYCLOOLEFIN COPOLYMER OBTAINED BY RING-OPENING POLYMERIZATION, USE THEREOF, AND PROCESS FOR PRODUCING RETARDATION PLATE COMPRISING THE COPOLYMER
  申请人：JSR Corporation

  公开号：EP1739113A1

  公开（公告）日：2007-01-03

  A cycloolefin copolymer obtained by ring opening polymerization according to the present invention is characterized by comprising a specific structural unit and exhibiting a single peak in a derivative differential scanning calorimetry curve obtained by differential scanning calorimeter (DSC), having a temperature width of the rising part in the peak of 35°C or below, and having a glass transition temperature (Tg) of 110°C or above. The cycloolefin copolymer provided by the present invention has excellent heat resistance and optical properties, is suitable for the formation of a film or sheet therefrom, and can be stretched even at a relatively low temperature around the Tg without causing troubles such as cloudiness. A film or sheet comprising the cycloolefin copolymer, which has excellent optical properties and heat resistance and is also suitable for stretching even at a relatively low temperature, is also provided. Further, there are also provided a retardation plate having excellent optical properties and heat resistance and having uniform retardation, and a process for producing the retardation plate.

  根据本发明通过开环聚合得到的环烯烃共聚物，其特征在于包含一个特定的结构单元，并在差示扫描量热仪（DSC）得到的导数差示扫描量热曲线中显示一个单一的峰值，峰值中上升部分的温度宽度为35℃或以下，玻璃化转变温度（Tg）为110℃或以上。本发明提供的环烯烃共聚物具有优异的耐热性和光学特性，适合用其制成薄膜或薄片，即使在 Tg 附近相对较低的温度下拉伸也不会产生浑浊等问题。此外，还提供了一种包含环烯烃共聚物的薄膜或薄片，该薄膜或薄片具有优异的光学特性和耐热性，即使在相对较低的温度下也适合拉伸。此外，还提供了一种具有优异光学性能和耐热性能且具有均匀缓凝效果的缓凝板，以及生产该缓凝板的工艺。