1H-蝶啶-4-硫酮 | 65882-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 1H-蝶啶-4-硫酮
• 英文名称: 4-Mercapto-pteridin
• 英文别名: Pteridine-4(1H)-thione；1H-pteridine-4-thione
• CAS: 65882-61-3
• 化学式: C₆H₄N₄S
• mdl: MFCD09754022
• 分子量: 164.191
• InChiKey: GTLUQRDIJWHQGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1H-蝶啶-4-硫酮 在 sodium hydroxide 、 一水合肼 作用下， 反应 2.0h， 生成 4-hydrazino-pteridine
  参考文献：
  名称：

  Albert et al., Journal of the Chemical Society, 1954, p. 3832,3833

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氨基吡嗪-2-甲腈 在 硫化氢 、 乙酸酐 作用下， 生成 1H-蝶啶-4-硫酮
  参考文献：
  名称：

  Albert et al., Journal of the Chemical Society, 1951, p. 474,478

  摘要：

  DOI：

文献信息

• PTERIDINES AND THEIR USE AS AGROCHEMICALS
  申请人：Brewster William K.

  公开号：US20110054173A1

  公开（公告）日：2011-03-03

  The present disclosure relates to 1- or 2-(4-(aryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and 1- or 2-(4-(heteroaryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and their use as agrochemicals and animal health products.

  本公开涉及1-或2-(4-(芳氧基)苯基)乙基氨基、氧基或硫基)喹啉和1-或2-(4-(杂芳氧基)苯基)乙基氨基、氧基或硫基)喹啉及其作为农药和动物健康产品的用途。
• Linker-Based Lecithin Microemulsion Delivery Vehicles
  申请人：Acosta-Zara Edgar Joel

  公开号：US20080139392A1

  公开（公告）日：2008-06-12

  The present invention relates to biocompatible microemulsion systems designed for controlled release drug delivery applications formulated with phospholipids such as lecithin (surfactant), a lipophilic additive (linker) containing 9 or more carbons in their alkyl group and hydrophilic-lipophilic balance (HLB) of 5 or less, and a surfactant-like hydrophilic additive (linker) containing between 6 to 9 carbon atoms in their alkyl tail. The combination of linkers and phospholipids produce formulations capable of delivering high concentrations of poorly soluble drugs into epithelial tissue using low surfactant concentrations, with minimum cytotoxic side effects.

  本发明涉及生物相容性微乳液系统，用于控制释放药物的应用，其配方包括磷脂类物质，如卵磷脂（表面活性剂），含有9个或更多碳原子的疏水性添加剂（连接剂），以及亲水-疏水平衡（HLB）为5或更低的类表面活性剂的亲水性添加剂（连接剂），连接剂和磷脂类物质的组合可产生配方，能够使用低表面活性剂浓度将高浓度的难溶性药物输送到上皮组织中，且具有最小的细胞毒性副作用。
• Thiol heterocyclic deodorant composition and method of deodorization
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0483426A1

  公开（公告）日：1992-05-06

  The present invention provides compositions containing a thiol heterocyclic compound and a topical carrier for topical application to the skin in the axilla or crotch region or to articles of clothing which are worn in the vicinity of such skin. The applicable deodorant agents comprise thiol heterocyclic compounds, or a pharmaceutically-acceptable salt thereof, comprising a heterocyclic ring structure having at least one heteroatom in the ring structure selected from the group consisting of oxygen, nitrogen, and sulfur; and wherein said heterocyclic ring structure has a least 1 thiol substituent attached to a carbon atom of said heterocyclic ring. Methods for controlling malodor comprising depositing onto skin in the axilla or crotch region, or to articles of clothing worn in the vicinity of the skin of a safe and effective amount of a thiol heterocyclic deodorant agent of the present invention are also provided.

  本发明提供了含有硫醇杂环化合物和局部载体的组合物，用于局部涂抹于腋窝或裆部皮肤，或涂抹于在这些皮肤附近穿着的衣物上。适用的除臭剂包括硫醇杂环化合物或其药学上可接受的盐，其包括杂环环结构，在环结构中具有至少一个选自氧、氮和硫组成的组的杂原子；其中所述杂环环结构具有至少一个连接到所述杂环环碳原子上的硫醇取代基。 还提供了控制恶臭的方法，包括将安全有效量的本发明硫醇杂环除臭剂涂抹在腋窝或裆部皮肤上，或涂抹在皮肤附近的衣物上。
• Parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same
  申请人：Platform Brightworks Two, Ltd.

  公开号：US10028949B2

  公开（公告）日：2018-07-24

  There may be provided compositions of lipophilic pharmaceutical agents with improved solubility and stability. For example, there may be provided a non-aqueous composition that comprises a lipophilic pharmaceutical agent, and an amphiphilic polymeric solvent such as PEG400 but essentially free of organic solvents and non-solubilized particles. The composition may be further diluted with a desired aqueous diluent such as an infusion fluid for parenteral administration to a subject such as a human. The compositions may be useful for the treatment for diseases or conditions that are sensitive to lipophilic agents, such as infectious diseases, malignant or autoimmune diseases.

  可提供具有更好溶解性和稳定性的亲脂性药剂组合物。例如，可以提供一种非水性组合物，其中包括亲脂性药剂和两亲性聚合物溶剂（如 PEG400），但基本上不含有机溶剂和非增溶颗粒。该组合物可进一步用所需的水性稀释剂稀释，如输液，用于人等受试者的非肠道给药。该组合物可用于治疗对亲脂性制剂敏感的疾病或病症，如传染性疾病、恶性或自身免疫性疾病。
• Compositions and methods for organ specific delivery of nucleic acids
  申请人：The Board of Regents of the University of Texas System

  公开号：US11229609B2

  公开（公告）日：2022-01-25

  The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

  本公开提供的组合物可将核酸组合物优先靶向或递送至特定器官。在某些实施方案中，组合物包含可用于递送核酸的类固醇或甾醇、可电离阳离子脂质、磷脂、PEG 脂质和永久阳离子脂质。