1alpha-脱氧-1alpha-叠氮基-4alpha-脱氧-4alpha-(胸腺激素-1-基)-2,3alpha:2alpha,5alpha-二脱水-L-阿卓糖醇 | 900513-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 1alpha-脱氧-1alpha-叠氮基-4alpha-脱氧-4alpha-(胸腺激素-1-基)-2,3alpha:2alpha,5alpha-二脱水-L-阿卓糖醇
• 英文名称: 1'-deoxy-1'-azido-4'-deoxy-4'-(thymin-1-yl)-2,3':2',5'-dianhydro-L-altritol
• 英文别名: 1alpha-DEOXY-1alpha-AZIDO-4alpha-DEOXY-4alpha-(THYMIN-1-YL)-2,3alpha:2alpha,5alpha-DIANHYDRO-L-ALTRITOL；(2S,3R,5S,6S)-5-(azidomethyl)-3-(hydroxymethyl)-11-methyl-4,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-10-one
• CAS: 900513-69-1
• 化学式: C₁₁H₁₃N₅O₄
• 分子量: 279.255
• InChiKey: QGJUYFLKZVELIB-XSPKLOCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  85.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1alpha-脱氧-1alpha-叠氮基-4alpha-脱氧-4alpha-(胸腺激素-1-基)-2,3alpha:2alpha,5alpha-二脱水-L-阿卓糖醇 在 4-甲苯硫酚 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  One-step synthesis of novel tricyclic isomeric azidonucleosides

  摘要：

  Several tricyclic azido-isonucleosides were formed in high yields by the treatment of pyrimidine isonucleosides with triphenylphosphine, tetrabromomethane, and sodium azide. The regioselective ring opening of these tricyclic azido-isonucleosides was also investigated. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.03.034
• 作为产物：
  描述：

  6'-O-benzoyl-1'-deoxy-1'-azido-4'-deoxy-4'-(thymin-1-yl)-2,3':2',5'-dianhydro-L-altritol 在 甲胺 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以98%的产率得到1alpha-脱氧-1alpha-叠氮基-4alpha-脱氧-4alpha-(胸腺激素-1-基)-2,3alpha:2alpha,5alpha-二脱水-L-阿卓糖醇
  参考文献：
  名称：

  One-step synthesis of novel tricyclic isomeric azidonucleosides

  摘要：

  Several tricyclic azido-isonucleosides were formed in high yields by the treatment of pyrimidine isonucleosides with triphenylphosphine, tetrabromomethane, and sodium azide. The regioselective ring opening of these tricyclic azido-isonucleosides was also investigated. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.03.034

文献信息

• One-step synthesis of novel tricyclic isomeric azidonucleosides
  作者：Zong-Sheng Li、Ren-Ping Qiao、Zhen-Jun Yang、Liang-Ren Zhang、Li-He Zhang

  DOI：10.1016/j.tetasy.2006.03.034

  日期：2006.4

  Several tricyclic azido-isonucleosides were formed in high yields by the treatment of pyrimidine isonucleosides with triphenylphosphine, tetrabromomethane, and sodium azide. The regioselective ring opening of these tricyclic azido-isonucleosides was also investigated. (c) 2006 Elsevier Ltd. All rights reserved.