2'-脱氧胞苷 3',5'-二磷酸酯 | 4682-43-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 中文名称: 2'-脱氧胞苷 3',5'-二磷酸酯
• 中文别名: 2'-脱氧胞苷3',5'-二磷酸酯
• 英文名称: 2‘-deoxycytidine-3‘,5'-O-bisphosphate
• 英文别名: O^3'_,O5'-diphosphono-2'-deoxy-cytidine；O^3'_,O5'-Diphosphono-2'-desoxy-cytidin；Desoxycytidin-3',5'-biphosphat；Desoxycytidin-3',5'-diphosphat；2'-Deoxycytidine 3',5'-diphosphate；[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate
• CAS: 4682-43-3
• 化学式: C₉H₁₅N₃O₁₀P₂
• 分子量: 387.18
• InChiKey: PIILJQRMNSOCFD-SHYZEUOFSA-N

物化性质

• 沸点：
  735.3±70.0 °C(Predicted)
• 密度：
  2.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  201
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2'-脱氧胞嘧啶核苷 在 O[P(O)Cl₂]2 作用下， 反应 4.0h， 生成 2'-脱氧胞苷 3',5'-二磷酸酯
  参考文献：
  名称：

  Solid-Phase Enzymatic Synthesis of Oligonucleotides

  摘要：

  [GRAPHICS]The controlled and selective synthesis of oligonucleotides on the solid phase is possible:under mild aqueous conditions using the enzyme T4 RNA ligase, the resins being tentagel or kieselguhr/polydimethylacrylamide.

  DOI：

  10.1021/ol990240n

文献信息

• Methods for modulating taste receptors
  申请人：MARS, INCORPORATED

  公开号：US11185100B2

  公开（公告）日：2021-11-30

  Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

  本文描述了存在于鲜味受体结构域中的氨基酸，其中氨基酸与至少一种核苷酸衍生物和/或至少一种跨膜化合物相互作用，从而增强、调节、增加和/或提高鲜味受体的活性。此类化合物可用于调味组合物，以增强食品的鲜味和/或适口性。
• Thannhauser; Ottenstein, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1921, vol. 114, p. 39,47
  作者：Thannhauser、Ottenstein

  DOI：——

  日期：——
• Dekker et al., Journal of the Chemical Society, 1953, p. 947,949,950
  作者：Dekker et al.

  DOI：——

  日期：——
• Diabetes in Elderly Adults
  作者：G. S. Meneilly、D. Tessier

  DOI：10.1093/gerona/56.1.m5

  日期：2001.1.1

  Diabetes is common in the elderly population. By the age of 75, approximately 20% of the population are afflicted with this illness. Diabetes in elderly adults is metabolically distinct from diabetes in)younger patient populations, and the approach to therapy needs to be different in this age group. Diabetes is associated with substantial morbidity from macro- and microvascular complications. Several lines of evidence suggest that optimal glycemic control and risk factor modification can substantially reduce the risk of complications in elderly patients. In the past, treatment options were limited. However, recent studies have delineated several new and exciting therapeutic opportunities for elderly patients with diabetes.
• Levene; Jacobs, Journal of Biological Chemistry, 1912, vol. 12, p. 411,415,420
  作者：Levene、Jacobs

  DOI：——

  日期：——