2,2,2-三氟-1-(4-氟苯基)乙胺盐酸盐 | 1184980-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,2,2-三氟-1-(4-氟苯基)乙胺盐酸盐
• 英文名称: 2,2,2-trifluoro-1-(4-fluorophenyl)ethan-1-amine hydrochloride
• 英文别名: 2,2,2-Trifluoro-1-(4-fluorophenyl)ethanamine hydrochloride；2,2,2-trifluoro-1-(4-fluorophenyl)ethanamine;hydrochloride
• CAS: 1184980-60-6
• 化学式: C₈H₇F₄N*ClH
• mdl: MFCD11226541
• 分子量: 229.605
• InChiKey: BMJQOPDJQFLGFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.26
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  6-氰基-3-吡啶磺酰氯 、 2,2,2-三氟-1-(4-氟苯基)乙胺盐酸盐 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 以59.4 %的产率得到N-(1-(4-chlorophenyl)-2,2,2-trifluoroethyl)-5-cyanopyridine-3-sulfonamide
  参考文献：
  名称：

  WO2023/94830

  摘要：

  公开号：
• 作为产物：
  描述：

  2,2,2,4'-四氟苯乙酮 在 盐酸 、 水 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 48.0h， 生成 2,2,2-三氟-1-(4-氟苯基)乙胺盐酸盐
  参考文献：
  名称：

  Thermocontrolled benzylimine–benzaldimine rearrangement over Nafion-H catalysts for efficient entry into α-trifluoromethylbenzylamines

  摘要：

  Nation-H and Nation SAC-13 are efficient solid Bronsted acid catalysts for the preparation of trifluoromethyl ketimines from benzylamines and trifluoromethylated ketones in high yields. A finely tuned benzylimine-benzaldimine rearrangement by facile 1,3-hydrogen shift has been achieved for the formation of fluorinated benzaldimines in high yields by careful optimization of reaction conditions including attempts under microwave conditions and a flow system. These alpha-trifluoromethylated benzaldimines are efficient precursors for pharmaceutically important alpha-trifluoromethylated benzylamines, accessed through their direct acid hydrolysis. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.088

文献信息

• [EN] SUBSTITUTED 1-OXO-ISOINDOLINE-5-CARBOXAMIDE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH<br/>[FR] COMPOSÉS DE 1-OXO-ISOINDOLINE-5-CARBOXAMIDE SUBSTITUÉS, COMPOSITIONS DE CEUX-CI, ET PROCÉDÉS DE TRAITEMENT ASSOCIÉS
  申请人：CELGENE CORP

  公开号：WO2020243379A1

  公开（公告）日：2020-12-03

  Provided herein are 1-oxo-isoindoline-5-carboxamide compounds having the following structure of Formula (I), wherein R1, R2, R3, R4 and n are as defined herein, compositions comprising an effective amount of a 1-oxo-isoindoline-5-carboxamide compound, and methods for treating or preventing disorders.

  本文提供了具有以下结构的1-氧代异吲哚啉-5-甲酰胺化合物的结构（I），其中R1、R2、R3、R4和n的定义如本文所述，包括有效量的1-氧代异吲哚啉-5-甲酰胺化合物的组合物，以及用于治疗或预防疾病的方法。
• SUBSTITUTED 1-OXO-ISOINDOLINE-5-CARBOXAMIDE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Celgene Corporation

  公开号：US20200377512A1

  公开（公告）日：2020-12-03

  Provided herein are 1-oxo-isoindoline-5-carboxamide compounds having the following structure: wherein R 1 , R 2 , R 3 , R 4 and n are as defined herein, compositions comprising an effective amount of a 1-oxo-isoindoline-5-carboxamide compound, and methods for treating or preventing disorders.
• Thermocontrolled benzylimine–benzaldimine rearrangement over Nafion-H catalysts for efficient entry into α-trifluoromethylbenzylamines
  作者：G.K. Surya Prakash、Kevin E. Glinton、Chiradeep Panja、Laxman Gurung、Patrice T. Battamack、Béla Török、Thomas Mathew、George A. Olah

  DOI：10.1016/j.tetlet.2011.11.088

  日期：2012.2

  Nation-H and Nation SAC-13 are efficient solid Bronsted acid catalysts for the preparation of trifluoromethyl ketimines from benzylamines and trifluoromethylated ketones in high yields. A finely tuned benzylimine-benzaldimine rearrangement by facile 1,3-hydrogen shift has been achieved for the formation of fluorinated benzaldimines in high yields by careful optimization of reaction conditions including attempts under microwave conditions and a flow system. These alpha-trifluoromethylated benzaldimines are efficient precursors for pharmaceutically important alpha-trifluoromethylated benzylamines, accessed through their direct acid hydrolysis. (C) 2011 Elsevier Ltd. All rights reserved.
• WO2023/94830
  申请人：——

  公开号：——

  公开（公告）日：——