2,2,3,3,4,4,5,5,6-九氟-6-(三氟甲基)四氢吡喃 | 356-47-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 中文名称: 2,2,3,3,4,4,5,5,6-九氟-6-(三氟甲基)四氢吡喃
• 中文别名: 肼磺酸,2-[1-(4-甲基苯基)亚乙基]-
• 英文名称: Perfluor-2-methyloxan
• 英文别名: 2,2,3,3,4,4,5,5,6-Nonafluorotetrahydro-6-(trifluoromethyl)-2H-pyran；2,2,3,3,4,4,5,5,6-nonafluoro-6-(trifluoromethyl)oxane
• CAS: 356-47-8
• 化学式: C₆F₁₂O
• 分子量: 316.046
• InChiKey: ZCPSRQQUNLMQMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  13

安全信息

• 海关编码：
  2932999099

反应信息

• 作为产物：
  描述：

  oxane-2-yl-methyl acetate 在 氢氟酸 作用下， 反应 5.95h， 以7.8 g的产率得到全氟(2-甲基-1,3,5-三氧杂螺[4.5]癸烷)
  参考文献：
  名称：

  环氧乙烷-2-基-羧酸，环氧乙烷-2-基-甲醇和环氧烷-2-基-甲醇衍生的几种酯的电化学氟化

  摘要：

  研究了环氧乙烷-2-基-羧酸（1），环氧乙烷-2-基-甲醇（2）和环氧烷-2-基-甲醇（3）的酯衍生物的电化学氟化（ECF）。全氟（氧杂环戊烷-2-基- carbonylfluoride）（4）从的衍生物获得的1和2，和全氟（氧杂环己烷-2-基- carbonylfluoride）（5从衍生物获得）3作为所需化合物，分别。从2和3的乙酸盐的ECF，还以低收率获得了具有二氧戊环环的全氟螺醚与所需的全氟酰氟（4和5）。通过分析通过与AlCl 3反应获得的氯化产物，证实了这些全氟螺醚的结构。

  DOI：

  10.1016/j.jfluchem.2004.11.014

文献信息

• METHODS OF INDUCING ANESTHESIA
  申请人：The Regents of the University of California

  公开号：EP3329966A1

  公开（公告）日：2018-06-06

  The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering an effective amount of an anesthetic compound identified according to the present methods.

  本发明提供了通过确定麻醉剂的摩尔水溶性来确定麻醉剂对麻醉剂敏感受体的选择性的方法。本发明进一步提供了通过改变或修饰麻醉剂使其具有较高或较低的水溶性来调节麻醉剂对麻醉剂敏感受体的选择性的方法。本发明进一步提供了通过施用有效量的根据本方法鉴定的麻醉剂化合物诱导受试者麻醉的方法。
• Methods of inducing anesthesia
  申请人：The Regents of the University of California

  公开号：US10010525B2

  公开（公告）日：2018-07-03

  The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.

  本发明提供了通过确定麻醉剂的摩尔水溶性来确定麻醉剂对麻醉剂敏感受体的选择性的方法。本发明进一步提供了通过改变或修饰麻醉剂使其具有较高或较低的水溶性来调节麻醉剂对麻醉剂敏感受体的选择性的方法。本发明进一步提供了通过呼吸途径（例如通过吸入或肺部给药）给药有效量的根据本发明方法鉴定的麻醉化合物，从而诱导受试者麻醉的方法。
• METHODS OF INDUCING SEDATION
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150157596A1

  公开（公告）日：2015-06-11

  The present invention provides methods for determining the selectivity of a sedative for an anesthetic-sensitive receptor by determining the molar water solubility of the sedative. The invention further provides methods for modulating the selectivity of a sedative for an anesthetic-sensitive receptor by altering or modifying the sedative to have higher or lower water solubility. The invention further provides methods of inducing sedation in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods and at a vapor pressure less than 0.1 atm (76 mm Hg).
• US4172016A
  申请人：——

  公开号：US4172016A

  公开（公告）日：1979-10-23
• US9381185B2
  申请人：——

  公开号：US9381185B2

  公开（公告）日：2016-07-05