2,2,6,6-四甲基哌啶-4-羧酸盐酸盐 | 65728-19-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2,2,6,6-四甲基哌啶-4-羧酸盐酸盐
• 英文名称: 2,2,6,6-tetramethylpiperidine-4-carboxylic acid
• 英文别名: 4-carboxy-2,2,6,6-tetramethylpiperidine；2,2,6,6-Tetramethylpiperidin-1-ium-4-carboxylate
• CAS: 65728-19-0
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: QKXWNEXHGMFIGB-UHFFFAOYSA-N

物化性质

• 熔点：
  >320°C
• 沸点：
  275.7±33.0 °C(Predicted)
• 密度：
  0.967±0.06 g/cm3(Predicted)
• 溶解度：
  溶于甲醇、水

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 储存条件：
  存储条件：2-8°C，密封保存，并保持干燥。

反应信息

• 作为反应物：
  描述：

  2,2,6,6-四甲基哌啶-4-羧酸盐酸盐 在 双氧水 作用下， 以 水 为溶剂， 以97.9 %的产率得到4-羧基-2,2,6,6-四甲基氮杂环己烷-1-氧基自由基
  参考文献：
  名称：

  CN116063224

  摘要：

  公开号：
• 作为产物：
  描述：

  2,2,6,6,-四甲基哌啶-4-甲腈 、 水 、 氢氧化钾 、 盐酸 在 二氯甲烷 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以to give the crude product 2,2,6,6-tetramethylpiperidine-4-carboxylic acid as a white solid (1.9 g, 83%)的产率得到
  参考文献：
  名称：

  MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

  摘要：

  本文提供了用于调节甲基修饰酶的代理，以及其组合物和用途。

  公开号：

  US20130310379A1

文献信息

• ORGANIC LIGHT-EMITTING DEVICE AND LIGHT-EMITTING APPARATUS INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：US20200266354A1

  公开（公告）日：2020-08-20

  Provided are an organic light-emitting device including a capping layer including an amine-based compound represented by a set or predetermined formula and a radical scavenger, and a light-emitting apparatus including the organic light-emitting device. The organic light-emitting device includes: a first electrode; a second electrode facing the first electrode; an organic layer between the first electrode and the second electrode and including an emission layer a capping layer on the second electrode, wherein the capping layer includes the amine-based compound.

  提供的是一种有机发光器件，包括一个封盖层，其中封盖层包括一种由一组预定公式表示的胺基化合物和一个自由基清除剂，并且包括这种有机发光器件的发光装置。该有机发光器件包括：第一电极；面对第一电极的第二电极；位于第一电极和第二电极之间的有机层，并包括一个发射层；覆盖在第二电极上的封盖层，其中封盖层包括这种胺基化合物。
• NOVEL COMPOSITIONS AND THERAPEUTIC METHODS
  申请人：AyuVis Research LLC

  公开号：US20170281667A1

  公开（公告）日：2017-10-05

  The present invention is directed to novel products, variants, pharmaceutically acceptable salts and prodrugs thereof, and medical use of such compounds for the treatment and/or management of sepsis, septicemia, septic shock, ocular infection, ocular inflammation, ocular angiogenesis, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel diseases (IBD), asthma, chronic obstructive pulmonary disease, fever syndromes, cachexia, psoriasis, autoimmune diseases, cardiac diseases, retinoblastoma, cancer and/or any disorder associated with inflammation, immunomodulation and microbial infection.

  本发明涉及新产品、变体、药用可接受的盐和前药，以及这些化合物的医学用途，用于治疗和/或管理败血症、败血症、脓毒性休克、眼部感染、眼部炎症、眼部血管生成、类风湿性关节炎（RA）、动脉粥样硬化、炎症性肠病（IBD）、哮喘、慢性阻塞性肺病、发热综合征、消瘦症、牛皮癣、自身免疫疾病、心脏疾病、视网膜母细胞瘤、癌症和/或任何与炎症、免疫调节和微生物感染有关的疾病。
• Hindered amine light stabilizers for polymers
  申请人：American Cyanamid Company

  公开号：US04369274A1

  公开（公告）日：1983-01-18

  Compounds of the formula ##STR1## and polymers thereof are useful as ultraviolet radiation stabilizers for polymers.

  式为##STR1##的化合物及其聚合物可作为聚合物的紫外线辐射稳定剂。
• 2,2,6,6-Tetramethyl-4-piperidyl spiro aliphatic ethers as stabilizers for synthetic polymers
  申请人：ADEKA ARGUS CHEMICAL CO., Ltd.

  公开号：EP0045358A2

  公开（公告）日：1982-02-10

  2,2,6,6-Tetramethyl-4-piperidyl spiro aliphatic ethers are provided, useful as stabilizers for organic polymeric materials, and having the general formula: wherein: Y1 is A,, A2, A3, A4, A5, and A6 each are selected from the group consisting of hydrogen; alkyl and hydroxyalkyl having from one to about eighteen carbon atoms; cycloalkyl having from three to about eight carbon atoms; aryl having from about six to about eighteen carbon atoms; acyl having from one to about eighteen carbon atoms wherein R4 is selected from the group consisting of aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocyclic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; carbamoyl wherein R5 is selected from the group consisting of aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocylic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; and monovalent oxyacid groups; at least one pair of A, and A2; A3 and A4; and A5 and A6 being taken together to form the group; wherein: Z is selected from the group consisting of hydrogen; oxyl 0; alkyl and hydroxyalkyl having from one to about twenty carbon atoms; and aryl and hydroxyaryl having from six to about twenty carbon atoms; X is selected from the group consisting of alkylene having from one to about eighteen carbon atoms; cycloalkylene having from three to about eight carbon atoms; arylene having from about six to about eighteen carbon atoms; polyacyl R4 wherein R4 is as above and n, is a number from 2 to 4; polycarbamoyl R5 wherein R5 is as above and n2 is a number from 2 to 4; and di- and trivalent oxyacid groups; R, and R2 each are selected from the group consisting of hydrogen; alkyl having from one to about eighteen carbon atoms; cycloalkyl having from three to about eight carbon atoms; aryl having from about six to about eighteen carbon atoms; carbamoyl wherein R5 is selected from the group consisting of aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocyclic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; and monovalent oxyacid groups; R3 is selected from the group consisting of alkyl having from one to about eighteen carbon atoms; cycloalkyl having from three to about eight carbon atoms; aryl having from about six to about eighteen carbon atoms; and -X-O-R1; R7 is selected from the group consisting of the residues of monohydric alcohols having from one to about eighteen carbon atoms and phenols having from six to about fifty carbon atoms; R" is selected from the group consisting of alkylene and oxyalkylene having from two to about ten carbon atoms and from zero to about five oxyether groups; cycloalkylene having from three to about eight carbon atoms; and arylene having from six to about fifty carbon atoms; and isocyanurate; m is a number from zero to 10; and p is zero or 1.

  本发明提供了 2,2,6,6-四甲基-4-哌啶基脂肪族螺醚，可用作有机聚合物材料的稳定剂，其通式为 其中Y1 是 A、A2、A3、A4、A5 和 A6 各选自氢；具有 1 至约 18 个碳原子的烷基和羟烷基；具有 3 至约 8 个碳原子的环烷基；具有约 6 至约 18 个碳原子的芳基；具有 1 至约 18 个碳原子的酰基组成的组 其中 R4 选自由 1 至约 18 个碳原子的脂肪族、3 至约 8 个碳原子的环脂族、6 至约 18 个碳原子的杂环族和 6 至约 18 个碳原子的芳香族组成的组； 氨基甲酰基 其中 R5 选自由 1 至约 18 个碳原子的脂肪族、3 至约 8 个碳原子的环脂族、6 至约 18 个碳原子的杂环族和 6 至约 18 个碳原子的芳香族组成的组； 和单价氧酸基团；至少有一对 A 和 A2、A3 和 A4 以及 A5 和 A6 共同组成该基团； 其中 Z 选自由氢、氧 0、具有 1 至约 20 个碳原子的烷基和羟基烷基以及具有 6 至约 20 个碳原子的芳基和羟基芳基组成的组； X 选自由 1 至约 18 个碳原子的亚烷基、3 至约 8 个碳原子的环亚烷基、约 6 至约 18 个碳原子的芳基、多酰基 R4 所组成的组。 其中 R4 如上，n 为 2 至 4 的数字； 聚氨基甲酰基 R5 其中 R5 如上，n2 为 2 至 4 的数字； 二价和三价氧酸基团； R和R2各自选自由下列物质组成的组：氢；具有 1 至约 18 个碳原子的烷基；具有 3 至约 8 个碳原子的环烷基；具有约 6 至约 18 个碳原子的芳基；氨基甲酰基 其中 R5 选自由 1 至约 18 个碳原子的脂肪族、3 至约 8 个碳原子的环脂族、6 至约 18 个碳原子的杂环族和 6 至约 18 个碳原子的芳香族组成的组； 以及单价氧酸基团； R3 选自由 1 至约 18 个碳原子的烷基、3 至约 8 个碳原子的环烷基、约 6 至约 18 个碳原子的芳基和-X-O-R1 组成的组； R7 选自具有 1 至约 18 个碳原子的一元醇残基和具有 6 至约 50 个碳原子的酚残基组成的组； R "选自由 2 至约 10 个碳原子和 0 至约 5 个氧醚基团的亚烷基和氧烷基、3 至约 8 个碳原子的环亚烷基和 6 至约 50 个碳原子的芳基组成的组；以及异氰尿酸酯； m 是零至 10 的数字；以及 p 为 0 或 1。
• Isopropylidenedicyclohexylene esters and their use as light stabilizers
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0032566A1

  公开（公告）日：1981-07-29

  Isopropylidenedicyclohexylene esters of 2,2,6,6-tetramethylpiperidine-4-carboxylic acid of formula: wherein R is hydrogen or alkyl (C1-C8); R' is hydrogen, hydroxyl or alkoxy (C,-C8); and R" is the group: and their use as light stabilizers for thermoplastic polymers such as polypropylene.

  式中 2，2，6，6-四甲基哌啶-4-羧酸的异亚丙基二环己烷酯： 其中 R 是氢或烷基（C1-C8）；R'是氢、羟基或烷氧基（C,-C8）；R" 是基团： 以及它们作为热塑性聚合物（如聚丙烯）的光稳定剂的用途。