2,3'-二硝基二苯砜 | 34418-84-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3'-二硝基二苯砜
• 英文名称: 1-nitro-2-((3-nitrophenyl)sulfonyl)benzene
• 英文别名: 2,3'-dinitrodiphenyl sulfone；(2-nitro-phenyl)-(3-nitro-phenyl)-sulfone；(2-Nitro-phenyl)-(3-nitro-phenyl)-sulfon；2,3'-Dinitrodiphenylsulfon；1-Nitro-2-(3-nitrophenyl)sulfonylbenzene
• CAS: 34418-84-3
• 化学式: C₁₂H₈N₂O₆S
• 分子量: 308.271
• InChiKey: VUAPECJJZHGQTQ-UHFFFAOYSA-N

物化性质

• 熔点：
  173-175 °C(Solv: acetic acid (64-19-7))
• 沸点：
  534.2±35.0 °C(Predicted)
• 密度：
  1.530±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  134
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,3'-二硝基二苯砜 在 盐酸 、 tin(ll) chloride 作用下， 生成 2-(3-氨基苯基)磺酰基苯胺
  参考文献：
  名称：

  SULFONES. I. THE ISOMERIC X,X'-DIAMINODIPHENYL SULFONES

  摘要：

  DOI：

  10.1021/jo01148a027
• 作为产物：
  描述：

  2-硝基二苯砜 在 硫酸 、 硝酸 作用下， 生成 2,3'-二硝基二苯砜
  参考文献：
  名称：

  SULFONES. I. THE ISOMERIC X,X'-DIAMINODIPHENYL SULFONES

  摘要：

  DOI：

  10.1021/jo01148a027

文献信息

• Silver-Promoted Decarboxylative Sulfonylation of Aromatic Carboxylic Acids with Sodium Sulfinates
  作者：Yongqi Yu、Qianlong Wu、Da Liu、Lin Yu、Ze Tan、Gangguo Zhu

  DOI：10.1021/acs.joc.9b01333

  日期：2019.9.6

  A novel and efficient synthesis of sulfones was developed via a silver-promoted decarboxylative sulfonylation reaction between aromatic carboxylic acids and sodium sulfinates for the first time. The approach features operational simplicity and good functional group compatibility and uses readily available starting materials. Furthermore, mechanistic studies reveal that the decarboxylative sulfonylation

  首次通过芳香族羧酸与亚磺酸钠之间的银促进的脱羧磺酰化反应，开发了一种新颖，有效的砜合成方法。该方法具有操作简单和良好的功能组兼容性的特点，并使用了容易获得的起始材料。此外，机理研究表明，脱羧磺酰化反应可能通过自由基机理进行。
• Convenient One-pot Procedure for Converting Aryl Sulfides to Nitroaryl Sulfones
  作者：Masatoshi Nose、Hitomi Suzuki

  DOI：10.1055/s-2002-31950

  日期：——

  When treated with nitrogen dioxide and ozone in inert solvent at 0 °C or below, aryl sulfides underwent smooth oxidative nitration to give nitroaryl sulfones in good yield. Using this methodology. a series of mono- and di-nitrated aryl sulfones were prepared from methyl phenyl sulfide and diphenyl sulfide and their physical data are presented.

  当在惰性溶剂中在 0 °C 或更低温度下用二氧化氮和臭氧处理时，芳基硫化物经历了平稳的氧化硝化反应，以良好的收率得到硝基芳基砜。使用这种方法。由甲基苯硫醚和二苯硫醚制备了一系列单硝基和二硝基芳基砜，并提供了它们的物理数据。
• Purification process of 3,3'-dinitrodiphenyl compounds
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0212823A1

  公开（公告）日：1987-03-04

  A crude 3,3'-dinitrodiphenyl compound selected from 3,3'-dinitrodiphenylsulfone or 3,3'-dinitrobenzophenone is purified by reacting the crude 3,3'-dinitrodiphenyl compound with a lower alcohol in the presence of a base so as to convert pracitcally the isomer or isomers, which contain one or more nitro groups at the ortho- or/and para-positions, only into the corresponding alkoxy compound or compounds thereof and then separating the alkoxy compound or compounds.

  选自 3,3'-二硝基二苯砜或 3,3'-二硝基二苯甲酮的粗制 3,3'-二硝基二苯化合物的提纯方法是：在碱存在下，将粗制 3,3'-二硝基二苯化合物与低级醇反应，以便将正位或/和对位含有一个或多个硝基的异构体转化为相应的烷氧基化合物，然后分离烷氧基化合物。
• Cell-permeable peptide inhibitors of the JNK signal transduction pathway
  申请人：Xigen S.A.

  公开号：EP2418217A1

  公开（公告）日：2012-02-15

  The present invention refers to protein kinase inhibitors and more specifically to inhibitors of the protein kinase c-Jun amino terminal kinase. Additionally, the present invention provides JNK inhibitor sequences, chimeric peptides, nucleic acids encoding same as well as pharmaceutical compositions for treating pathophysiologies associated with JNK signaling.

  本发明是指蛋白激酶抑制剂，更具体地说是指蛋白激酶c-Jun氨基末端激酶的抑制剂。此外，本发明还提供了JNK抑制剂序列、嵌合肽、编码嵌合肽的核酸以及治疗与JNK信号转导相关的病理生理的药物组合物。
• Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases
  申请人：Xigen S.A.

  公开号：EP2489361A1

  公开（公告）日：2012-08-22

  The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor sequences, chimeric peptides, or of nucleic acids encoding same as well as pharmaceutical compositions containing same, for the treatment of various diseases or disorders strongly related to JNK signaling, wherein these diseases or disorders are selected from autoimmune disorders, cardiovascular diseases, cancerous diseases, diabetes, including diabetes type 1 or type 2, inflammatory diseases, hair loss, including Alopecia areata, diseases of the lung, neuronal or neurodegenerative diseases, diseases of the liver, diseases of the spine, diseases of the uterus, viral infectious diseases and depressive disorders.

  本发明是指使用蛋白激酶抑制剂，更具体地说是使用蛋白激酶c-Jun氨基末端激酶抑制剂、JNK抑制剂序列、嵌合肽或编码它们的核酸以及含有它们的药物组合物来治疗与JNK信号转导密切相关的各种疾病或紊乱、其中，这些疾病或紊乱选自自身免疫性疾病、心血管疾病、癌症疾病、糖尿病（包括 1 型或 2 型糖尿病）、炎症性疾病、脱发（包括斑秃）、肺部疾病、神经元或神经退行性疾病、肝脏疾病、脊柱疾病、子宫疾病、病毒性传染病和抑郁症。