2,3,4-5-四氯-4-羟基联苯 | 67651-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3,4-5-四氯-4-羟基联苯
• 中文别名: 4-羟基-2',3',4',5'-四氯联苯
• 英文名称: 2,3,4,5-Tetrachloro-4'-biphenylol
• 英文别名: 4-(2,3,4,5-tetrachlorophenyl)phenol
• CAS: 67651-34-7
• 化学式: C₁₂H₆Cl₄O
• 分子量: 308.0
• InChiKey: RESKVBRHSNTJNG-UHFFFAOYSA-N

物化性质

• 碰撞截面：
  163.1 Ų [M-H]-

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES
  申请人：Kelly Jeffery W.

  公开号：US20100120919A1

  公开（公告）日：2010-05-13

  Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods are disclosed.

  转甲状腺素原生态状态的动力学稳定是预防蛋白质错折的有效机制。因为转甲状腺素错折在转甲状腺素淀粉样病中起着重要作用，抑制这种错折可以用作有效的治疗或预防此类疾病的方法。本文公开了治疗方法。
• GENETICALLY-MUTATED BACTERIAL STRAIN FOR DETECTING ESTROGENIC COMPOUND AND METHOD FOR DETECTING ESTROGENIC COMPOUND USING THE SAME
  申请人：INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY

  公开号：US20190127774A1

  公开（公告）日：2019-05-02

  The present invention relates to a genetically mutated bacteria strain for detecting an estrogenic compound and a method for detecting an estrogenic compound by using the same. More specifically, the present invention relates to a bacteria strain having an ability to detect an estrogenic compound, transformed by plasmid A comprising base sequences in which a gene for encoding a coactivator interacting with an estrogen receptor ligand binding domain (ER LBD) is conjugated to a gene for encoding λCI protein, and plasmid B in which a gene for encoding an estrogen receptor ligand binding domain (ER LBD) is conjugated to a gene for encoding αNTD protein, and a method for detecting an estrogenic compound by using same. The present invention can provide genetically mutated bacteria for detecting an estrogenic compound and a method for detecting an estrogenic compound by using same since the bacteria are based on estrogen receptor protein originated from the human body, and thus are environmentally friendly, and the detection of the bacteria can be performed in a very short time with low cost and labor by virtue of a relatively simple process.
• US7996156B2
  申请人：——

  公开号：US7996156B2

  公开（公告）日：2011-08-09
• US8168663B2
  申请人：——

  公开号：US8168663B2

  公开（公告）日：2012-05-01
• US8653119B2
  申请人：——

  公开号：US8653119B2

  公开（公告）日：2014-02-18