2,3-二羟基-2-苯基苯丙酮 | 15121-78-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 2,3-二羟基-2-苯基苯丙酮
• 英文名称: α-hydroxymethylbenzoin
• 英文别名: hydroxymethylbenzoin；2,3-dihydroxy-1,2-diphenyl-propan-1-one；2,3-Dihydroxy-1,2-diphenyl-propan-1-on；2,3-dihydroxy-2-phenylpropiophenone；2,3-dihydroxy-1,2-diphenyl-1-propanone；α-hydroxymethyl-benzoin；2,3-Dihydroxy-1,2-diphenylpropan-1-one
• CAS: 15121-78-5
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: AOGNACZDZNOTSN-UHFFFAOYSA-N

物化性质

• 熔点：
  85.5 °C
• 沸点：
  460.5±45.0 °C(Predicted)
• 密度：
  1.248±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2914400090

反应信息

• 作为反应物：
  描述：

  2,3-二羟基-2-苯基苯丙酮 在 对甲苯磺酸 、 paraformaldehyde 作用下， 以 水 、 甲苯 为溶剂， 生成 phenyl-4-phenyl-4-(1,3-dioxolane)ketone
  参考文献：
  名称：

  Dioxolane derivatives and use as photoinitiators

  摘要：

  二氧杂环戊烷化合物可用于启动光聚合反应，包含这种化合物的可聚合物组合物。

  公开号：

  US04072694A1
• 作为产物：
  描述：

  联苯甲酰 在 rongalite 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.67h， 以60%的产率得到安息香精油
  参考文献：
  名称：

  Harris, Alan R.; Mason, Timothy J., Synthetic Communications, 1989, vol. 19, # 3and4, p. 529 - 536

  摘要：

  DOI：

文献信息

• [EN] DENTAL COMPOSITION CONTAINING POLYOXOMETALATES, PROCESS OF PRODUCTION AND USE THEREOF<br/>[FR] COMPOSITION DENTAIRE CONTENANT DES POLYOXOMÉTALATES, PROCÉDÉS DE PRODUCTION ET D'UTILISATION DE LADITE COMPOSITION
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2015034977A1

  公开（公告）日：2015-03-12

  The invention relates to a curable composition for dental use comprising polyoxymetalates and/or derivatives thereof in an amount of at least about 5 wt.-% with respect to the weight of the composition.

  该发明涉及一种可治疗的牙科用组合物，其包括聚氧金属酸盐和/或其衍生物，其在组合物的重量上占至少约5重量百分比。
• Development of Photobase Generator with Benzoin Derivatives and Its Application to Photosensitive Materials
  作者：Nobuhiro Ishikawa、Koji Arimitsu、Takahiro Gunji、Yoshimoto Abe

  DOI：10.1246/cl.131148

  日期：2014.5.5

  We developed novel photobase generators (PBGs) that generate radicals and aliphatic amines simultaneously. We demonstrated that the PBGs induced radical polymerization and hydrolytic polycondensation. A film of poly[(methacryloxypropyl)silsesquioxane] (MA-PS) was cured in the presence of a PBG upon UV-light irradiation at 254 nm. This result showed that radical polymerization of methacryloyl groups of MA-PS with the photogenerated radicals and the crosslinking reactions based on the base-catalyzed condensation reactions of alkoxysilyl units of MA-PS proceeded. Furthermore, pencil hardness showed HB at 1.0 J cm−2 and 4H at 21.6 J cm−2 without heat treatment.

  我们开发了一种新型光碱基生成剂（PBGs），能同时生成自由基和脂肪族胺。我们证明这些PBGs引发了自由基聚合和缩聚反应。在254 nm紫外光的照射下，含有PBGs的聚[(甲基丙烯酰氧丙基)倍半硅氧烷]（MA-PS）薄膜完成固化。这一结果表明，MA-PS中的甲基丙烯酰基团与光生自由基之间进行了自由基聚合反应，同时基于碱催化缩合反应的MA-PS中的烷氧基硅单元产生了交联反应。此外，未经热处理，铅笔硬度显示在1.0 J cm−2时为HB，21.6 J cm−2时增加到4H。
• Preparation method of copolymerizable photoinitiators
  申请人：Agfa Graphics N.V.

  公开号：EP2065362A1

  公开（公告）日：2009-06-03

  An intermediate for preparing (meth)acrylated photoinitiators according to Formula (I): wherein: R1 is selected from the group consisting of hydrogen and a methyl group; A represents a group comprising at least one photoinitiating moiety; L represents a n+o-valent linking group comprising at least one carbon atom; n and o each independently represent an integer from 1 to 4; p is equal to 0 or 1; X represents a group selected from the group consisting of Cl, Br, I and R2SO3; and R2 represents an optionally substituted group selected from the group consisting of an alkyl group, an alkenyl group, an alkynyl group, an alkaryl group , an aralkyl group, an aryl group and a heteroaryl group. A method for the preparation of (meth)acrylated photoinitiators by β-elimination of HX from the intermediate according to Formula (I) is also disclosed.

  根据公式（I），制备（甲基）丙烯酸光引发剂的中间体，其中：R1选择自氢和甲基；A代表包含至少一个光引发基团的基团；L代表包含至少一个碳原子的n+o价键合基团；n和o各自独立地表示1至4之间的整数；p等于0或1；X代表选择自Cl、Br、I和R2SO3的基团；R2代表选择自烷基、烯基、炔基、烷芳基、芳基和杂环芳基的可选择取代基团。还公开了一种通过从公式（I）中间体中β-消除HX制备（甲基）丙烯酸光引发剂的方法。
• ANTIHYPERTENSIVE POLYOL COMPOUND AND DERIVATIVE THEREOF
  申请人：East China University of Science and Technology

  公开号：EP3906969A1

  公开（公告）日：2021-11-10

  The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

  本发明提供了一种由式I代表的化合物，或其药用可接受的盐或酯，前药，光学异构体，立体异构体或其溶剂合物。本发明提供的化合物可用于制备用于预防或治疗高血压或与高血压相关疾病，或肺动脉高压或与肺动脉高压相关疾病的药物。本发明提供的化合物与现有用于治疗高血压和肺动脉高压的药物具有不同的机制，从而为开发用于治疗高血压和肺动脉高压的药物奠定了新的物质基础。
• PHOTOLATENT CATALYSTS BASED ON ORGANOMETALLIC COMPOUNDS
  申请人：Kohli Steck Rachel

  公开号：US20100234485A1

  公开（公告）日：2010-09-16

  The present invention provides organometallic latent catalyst compounds, which are suitable as catalysts in polyaddition or polycondensation reactions which are catalysed by a Lewis acid type catalyst, in particular for the crosslinking of a blocked or unblocked isocyanate or isothiocyanate component with a polyol or polythiolto form a polyurethane (PU).

  本发明提供了有机金属潜伏催化剂化合物，适用于由Lewis酸类催化剂催化的聚加成反应或缩聚反应中作为催化剂，特别是用于将受阻或未受阻的异氰酸酯或异硫氰酸酯组分与多元醇或多硫醇交联以形成聚氨酯（PU）。