氯甲基膦酸二戊酯 | 100536-23-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 氯甲基膦酸二戊酯
• 英文名称: chloromethyl-phosphonic acid dipentyl ester
• 英文别名: Chlormethyl-phosphonsaeure-dipentylester；1-[Chloromethyl(pentoxy)phosphoryl]oxypentane
• CAS: 100536-23-0
• 化学式: C₁₁H₂₄ClO₃P
• 分子量: 270.737
• InChiKey: KGCFIMMXCPAQGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  戊醇 、 O,O-双(三氟乙基)氯甲基膦酸酯 在 lithium 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以88%的产率得到氯甲基膦酸二戊酯
  参考文献：
  名称：

  New route to amino[²H₂]methylphosphonic acid via bis(trifluoroethyl) phosphonate transesterification

  摘要：

  Transesterification of bis(trifluoroethyl) chloromethyl- and azidomethyl-phosphonates with alcohols in the presence of catalytic quantities of alcoholates gives dialkyl chloromethyl- and azidomethyl-phosphonates in good yield. This process has been used for the synthesis of dibenzyl azido[H-2(2)]methylphosphonate which has been reduced and hydrogenolised to amino[H-2(2)]methylphosphonic acid under neutral conditions.

  DOI：

  10.1039/p19950003125

文献信息

• Plastic compositions containing dialkyl monochlorophosphonate esters
  申请人：VICTOR CHEMICAL WORKS

  公开号：US02836504A1

  公开（公告）日：1958-05-27
• New route to amino[²H₂]methylphosphonic acid via bis(trifluoroethyl) phosphonate transesterification
  作者：Sylvie Berté-Verrando、Rachel Dizière、Mohammad Samadi、Philippe Savignac

  DOI：10.1039/p19950003125

  日期：——

  Transesterification of bis(trifluoroethyl) chloromethyl- and azidomethyl-phosphonates with alcohols in the presence of catalytic quantities of alcoholates gives dialkyl chloromethyl- and azidomethyl-phosphonates in good yield. This process has been used for the synthesis of dibenzyl azido[H-2(2)]methylphosphonate which has been reduced and hydrogenolised to amino[H-2(2)]methylphosphonic acid under neutral conditions.