2,4,6-三甲基-3-苯基吡啶 | 53911-39-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,4,6-三甲基-3-苯基吡啶
• 英文名称: 2,4,6-trimethyl-3-phenylpyridine
• 英文别名: 3-phenyl-2,4,6-trimethylpyridine；2,4,6-trimethyl-3-phenyl-pyridine；2,4,6-Trimethyl-3-phenylpyridin
• CAS: 53911-39-0
• 化学式: C₁₄H₁₅N
• 分子量: 197.28
• InChiKey: RBQYYKPIUNQAQV-UHFFFAOYSA-N

物化性质

• 沸点：
  119 °C(Press: 3 Torr)
• 密度：
  1.002±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-phenyl-2,4,6-trimethylpyrylium tetrafluoroborate 在 ammonium hydroxide 作用下， 以 水 为溶剂， 以24%的产率得到2,4,6-三甲基-3-苯基吡啶
  参考文献：
  名称：

  Rajoharison, Harivelo G.; Roussel, Christian, Bulletin de la Societe Chimique de France, 1986, # 2, p. 307 - 313

  摘要：

  DOI：

文献信息

• A convenient route to symmetrically and unsymmetrically substituted 3,5-diaryl-2,4,6-trimethylpyridines via Suzuki–Miyaura cross-coupling reaction
  作者：Dariusz Błachut、Joanna Szawkało、Zbigniew Czarnocki

  DOI：10.3762/bjoc.12.82

  日期：——

  A series of differently substituted 3,5-diaryl-2,4,6-trimethylpyridines were prepared and characterized using the Suzuki-Miyaura coupling reaction with accordingly selected bromo-derivatives and arylboronic acids. The reaction conditions were carefully optimized allowing high yield of isolated products and also the construction of unsymmetrically substituted diarylpyridines, difficult to access by

  制备了一系列不同取代的3,5-二芳基-2,4,6-三甲基吡啶，并使用Suzuki-Miyaura偶联反应与相应选择的溴代衍生物和芳基硼​​酸进行了表征。仔细优化了反应条件，可实现高收率的分离产物，以及不对称取代的二芳基吡啶的构建，难以通过其他方法获得。
• Process for preparing pyrylium salts
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0096641A2

  公开（公告）日：1983-12-21

  A process for selectively preparing isomers of polysubstituted pyrylium salts from isoolefins or isoolefin precursors comprises diacylating the isoolefin or isoolefin precursor with a carboxylic acid anhydride in the presence of an acid having a Hammett acidity function, when pure, between -10 and -5. This method is selective to obtain the most substituted isomer of pyrylium salt that can be obtained from the isoolefin or isoolefin precursor.

  一种从异烯烃或异烯烃前体中选择性制备多取代芘盐异构体的工艺，包括在纯度为-10 和-5 之间的哈密特酸度函数的酸存在下，用羧酸酐对异烯烃或异烯烃前体进行二酰化。
• Rhenium-Catalyzed Regioselective Synthesis of Multisubstituted Pyridines from β-Enamino Ketones and Alkynes via C–C Bond Cleavage
  作者：Shun-ichi Yamamoto、Kana Okamoto、Makiko Murakoso、Yoichiro Kuninobu、Kazuhiko Takai

  DOI：10.1021/ol301273j

  日期：2012.6.15

  A new method is described for the regioselective synthesis of multisubstituted pyridine derivatives. Treatment of N-acetyl beta-enamino ketones with alkynes in the presence of the rhenium catalyst, Re-2(CO)(10), gives multisubstituted pyridines regioselectively. In this reaction, the N-acetyl moieties are important for the selective formation of the multisubstituted pyridines. This reaction proceeds via insertion of alkynes into a carbon carbon single bond of beta-enamino ketones, intramolecular nucleophilic cyclization, and elimination of acetic acid.
• BOTA A.; BALABAN A. T.; CHIRALEU F., REV. ROUM. CHIM. <RRCH-AC>, 1976, 21, NO 1, 101-106
  作者：BOTA A.、 BALABAN A. T.、 CHIRALEU F.

  DOI：——

  日期：——
• US4642359A
  申请人：——

  公开号：US4642359A

  公开（公告）日：1987-02-10