2,4-二甲基-3-呋喃酰氯 | 15139-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 中文名称: 2,4-二甲基-3-呋喃酰氯
• 英文名称: 2,4-Dimethylfuran-3-carbonsaeurechlorid
• 英文别名: 2,4-dimethyl-furan-3-carbonyl chloride；2,4-dimethylfuran-3-carboxylic chloride；2,4-dimethyl-3-furoyl chloride；2,4-Dimethylfuran-3-carbonyl chloride
• CAS: 15139-39-6
• 化学式: C₇H₇ClO₂
• mdl: MFCD13151978
• 分子量: 158.584
• InChiKey: NOEQXZGBSMGWCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2932190090

反应信息

• 作为反应物：
  描述：

  2,4-二甲基-3-呋喃酰氯 在 吡啶 、 乙醚 、 羟胺 、 溶剂黄146 、 锌 作用下， 生成 2,4-dimethyl-furan-3-carbaldehyde-oxime
  参考文献：
  名称：

  Über2,4-二甲基-呋喃-3-醛

  摘要：

  DOI：

  10.1002/hlca.193201501122
• 作为产物：
  描述：

  (3-羧基-4-甲基-[2]呋喃基)-乙酸 在 氯化亚砜 作用下， 生成 2,4-二甲基-3-呋喃酰氯
  参考文献：
  名称：

  Über2,4-二甲基-呋喃-3-醛

  摘要：

  DOI：

  10.1002/hlca.193201501122

文献信息

• [EN] INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES<br/>[FR] INGÉNOL-3-ACYLATES III ET INGÉNOL-3-CARBAMATES
  申请人：LEO PHARMA AS

  公开号：WO2012083953A1

  公开（公告）日：2012-06-28

  The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is -NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

  该发明涉及一般式I的化合物，其中R为杂环芳基，可选择地由R7取代；或R为杂环烷基或杂环烯基，可选择地由R8取代；或R为X，其中X为-NR11R12；以及其在治疗中的药物可接受的盐、水合物或溶剂合物，用于单独使用或与一个或多个其他药用活性化合物结合在一起，用于预防、治疗或改善对中性粒细胞氧化爆发的刺激响应、对角质细胞IL-8释放的刺激响应或对坏死诱导的刺激响应的疾病或症状。
• 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for
  申请人：Euro-Celtique, S.A.

  公开号：US06166041A1

  公开（公告）日：2000-12-26

  Novel compounds which are effective PDE IV inhibitors are disclosed. The present invention is directed to compounds having the general formula I ##STR1## wherein: X is a halogen; Q is --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --, a single or a double bond, or --NR.sub.1 --; R.sub.1 is a C.sub.3-7 monocyclic ring structure containing at least one carbon atom and comprising one or more chalcogen atoms selected from the group consisting of nitrogen, sulfur and oxygen, wherein the monocyclic ring is unsaturated, partially unsaturated or saturated, and is optionally substituted with alkyl, cycloalkyl, alkoxy, cycloalkoxy, hydroxy or halogen; or is a bicyclic structure, comprised of a phenyl ring fused to a monocyclic ring structure as defined above, or comprised of two fused monocyclic ring structures, each ring containing at least one carbon atom and comprising one or more chalcogen atoms selected from the group consisting of nitrogen, sulfur and oxygen, wherein the monocyclic ring is unsaturated, partially unsaturated or saturated, and is optionally substituted with alkyl, cycloalkyl, alkoxy, cycloalkoxy, hydroxy or halogen. R.sub.2 is a phenyl group or a C.sub.3-7 monocyclic ring structure containing at least one carbon atom and comprising one or more chalcogen atoms selected from the group consisting of nitrogen, sulfur and oxygen, wherein the monocyclic ring may be unsaturated, partially unsaturated or saturated, and is optionally substituted with alkyl, cycloalkyl, alkoxy, cycloalkoxy, hydroxy or halogen.

  揭示了有效的PDE IV抑制剂的新型化合物。本发明涉及具有一般式I的化合物 其中：X是卤素；Q是--CH.sub.2 --CH.sub.2 --，--CH.sub.2 --，一个单键或双键，或--NR.sub.1 --；R.sub.1是含有至少一个碳原子并包含一种或多种来自氮、硫和氧的卤素原子的C.sub.3-7单环结构，其中单环结构不饱和、部分不饱和或饱和，并且可以用烷基、环烷基、烷氧基、环烷氧基、羟基或卤素取代；或者是一个双环结构，由一个苯环与上述定义的单环结构融合而成，或由两个融合的单环结构组成，每个环含有至少一个碳原子并包含一种或多种来自氮、硫和氧的卤素原子，其中单环结构不饱和、部分不饱和或饱和，并且可以用烷基、环烷基、烷氧基、环烷氧基、羟基或卤素取代。R.sub.2是苯基或含有至少一个碳原子并包含一种或多种来自氮、硫和氧的卤素原子的C.sub.3-7单环结构，其中单环结构可以是不饱和的、部分不饱和的或饱和的，并且可以用烷基、环烷基、烷氧基、环烷氧基、羟基或卤素取代。
• Certain N-methoxy-N-cycloalkyl-2-methyl-3-furancarboxamides and
  申请人：BASF Aktiengesellschaft

  公开号：US03993772A1

  公开（公告）日：1976-11-23

  New and valuable furanhydroxamic acid derivatives having a good fungicidal action, fungicides containing these compounds as active ingredients, a process for controlling the growth of fungi with these compounds, and a process for their manufacture.

  具有良好杀菌作用的新型和有价值的呋喃羟肟酸衍生物，含有这些化合物作为活性成分的杀菌剂，使用这些化合物控制真菌生长的过程，以及它们的制造过程。
• INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
  申请人：Grue-Sørensen Gunnar

  公开号：US20140303150A1

  公开（公告）日：2014-10-09

  The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

  本发明涉及一般式I的化合物，其中R是杂环芳基，可选择由R7取代; 或R是杂环烷基或杂环烯基，可选择由R8取代; 或R是X，其中X是—NR11R12;以及其药学上可接受的盐、水合物或溶剂化物，用于治疗，单独或与一个或多个其他药学活性化合物联合使用，预防、治疗或改善对嗜中性粒细胞氧化爆发刺激、对角质细胞IL-8释放刺激或对坏死诱导反应的疾病或病情的响应。
• PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS
  申请人：CARDIOXYL PHARMACEUTICALS

  公开号：US20150366977A1

  公开（公告）日：2015-12-24

  The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

  本公开提供了含有N-取代羟胺衍生物的亚硝酰基供体药物组合物。该组合物在治疗心血管疾病（如心力衰竭）方面具有高效性，具有适当的毒理学特性，并且对于静脉或口服给药具有足够的稳定性。