2,4’-异亚丙基二苯酚 | 837-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4’-异亚丙基二苯酚
• 中文别名: 2,4'-异亚丙基二苯酚；2β-反式-降钙素醇
• 英文名称: 2-[1-(4-hydroxyphenyl)-1-methylethyl]-phenol
• 英文别名: Phenol, 2-[1-(4-hydroxyphenyl)-1-methylethyl]-；2-[2-(4-hydroxyphenyl)propan-2-yl]phenol
• CAS: 837-08-1
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: MLCQXUZZAXKTSG-UHFFFAOYSA-N

物化性质

• 熔点：
  110.5 °C
• 沸点：
  381.8±22.0 °C(Predicted)
• 密度：
  1.143±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2907299090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  2,4’-异亚丙基二苯酚 在 DIAION SK-104H 作用下， 反应 8000.0h， 生成 双酚A
  参考文献：
  名称：

  EP1985602

  摘要：

  公开号：
• 作为产物：
  描述：

  苯酚 、 丙酮 生成 2,4’-异亚丙基二苯酚
  参考文献：
  名称：

  IIMURO, SHIGERU;KITAMURA, TAKASHI;MORIMOTO, YOSHIO

  摘要：

  DOI：

文献信息

• Organized Surface Functional Groups:  Cooperative Catalysis via Thiol/Sulfonic Acid Pairing
  作者：Eric L. Margelefsky、Ryan K. Zeidan、Véronique Dufaud、Mark E. Davis

  DOI：10.1021/ja074761e

  日期：2007.11.1

  synthesis and characterization of heterogeneous catalysts containing surfaces functionalized with discrete pairs of sulfonic acid and thiol groups are reported. A catalyst having acid and thiol groups separated by three carbon atoms is ca. 3 times more active than a material containing randomly distributed acid and thiol groups in the condensation of acetone and phenol to bisphenol A and 14 times more

  报道了含有用不连续的磺酸和硫醇基团对官能化的表面的多相催化剂的合成和表征。具有由三个碳原子隔开的酸和硫醇基团的催化剂是大约。在丙酮和苯酚缩合为双酚 A 时比含有随机分布的酸和硫醇基团的材料活性高 3 倍，在环己酮和苯酚缩合为双酚 Z 时活性高 14 倍。 增加配对材料中的酸/硫醇距离降低活性和选择性。这项工作清楚地揭示了多相催化剂表面上两个不同官能团的纳米级组织的重要性。
• Optically active compound and photosensitive resin composition
  申请人：——

  公开号：US20030211421A1

  公开（公告）日：2003-11-13

  A photoactive compound is used in combination with a photosensitizer, represented by the following formula (1): A −[( J ) m −( X-Pro )] n (1) wherein A represents a hydrophobic unit comprising at least one kind of hydrophobic groups selected from a hydrocarbon group and a heterocyclic group, J represents a connecting group, X-Pro represents a hydrophilic group protected by a protective group Pro which is removable by light exposure, m represents 0 or 1, and n represents an integer of not less than 1. The protective group Pro may be removable by light exposure in association with the photosensitizer (especially, a photo acid generator), or may be a hydrophobic protective group. The hydrophilic group may be a hydroxyl group or a carboxyl group. The photoactive compound has high sensitivity to a light source of short wavelength beams, for resist application, therefore, the photoactive compound is advantageously used for forming a pattern with high resolution.

  一种光活性化合物与光敏剂结合使用，由以下公式（1）表示： A −[( J ) m −( X-Pro )] n (1) 其中，A代表至少包括一种从烃基和杂环基中选择的疏水基的疏水单元，J代表连接基团，X-Pro代表由光照可去除的保护基团Pro保护的亲水基团，m代表0或1，n代表不少于1的整数。 保护基团Pro可以与光敏剂（特别是光酸发生剂）一起通过光照可去除，也可以是疏水保护基团。亲水基团可以是羟基或羧基。光活性化合物对短波长光源具有很高的敏感性，用于光刻应用，因此，该光活性化合物有利于形成具有高分辨率的图案。
• Self-assembly synthesis of a high-content sulfonic acid group functionalized ordered mesoporous polymer-based solid as a stable and highly active acid catalyst
  作者：Wei Wang、Xin Zhuang、Qingfei Zhao、Ying Wan

  DOI：10.1039/c2jm32894a

  日期：——

  A stable and highly active ordered mesoporous polymer-based acid catalyst has been prepared via a simple surfactant templating approach and oxidation treatment. The composition and nanostructure are characterized by XRD, NMR, XPS, TEM, nitrogen sorption, elemental and chemical analysis. The sulfonic acid groups have been anchored within the well-arranged channels of the polymer-based matrix. Even with a high –SO3H group loading (up to about 27.4 wt%) on the mesoporous polymer-based material, the ordered mesostructure and high surface area (∼400 m2 g−1) can be retained and the functional moieties are highly chemically accessible. With the large number of acid sites (0.93–2.38 H+ mmol g−1 determined by acid–base titration) and the hydrophobic character, the mesoporous polymer-based solid exhibits unique catalytic performance in acid-catalyzed reactions such as condensation and acetalization, not only high activity (per site yield of bisphenol-A is over 45 in the condensation of phenol and acetone) but also excellent stability. Loss in acidic loading and activity is negligible even after the catalyst is reused 20 times in the acetalization of butanediol and aldehyde. The stability is most likely attributed to the hydrophobic nature of the mesoporous polymer-based solids, which favors the diffusion of water and thereby inhibits the poisoning of acidic sites caused by water generating in the reaction. Moreover, with large mesopores, the diffusion of reactants and products can be promoted and hence the catalytic activity can be further increased.

  一种稳定且高活性的有序介孔聚合物基酸催化剂通过简单的表面活性剂模板法和氧化处理制备而成。通过XRD、NMR、XPS、TEM、氮气吸附、元素和化学分析对其成分和纳米结构进行了表征。磺酸基团已被锚定在聚合物基基体的井然有序的通道内。即使在介孔聚合物基材料上具有高达约27.4 wt%的–SO3H基团负载，有序的介观结构和高比表面积（约400 m²/g）依然能够保持，功能性基团具有较高的化学可接近性。由于大量的酸位（通过酸碱滴定测定为0.93–2.38 H+/mmol g−1）以及疏水性，这种介孔聚合物基固体在酸催化反应中表现出独特的催化性能，如缩合反应和缩醛化反应，不仅活性高（在苯酚与丙酮的缩合反应中，每个活性位点产生的双酚A的产率超过45），而且稳定性也极佳。即使催化剂在丁二醇和醛的缩醛化反应中重复使用20次，酸负载和活性的损失也是微不足道的。这种稳定性很可能归因于介孔聚合物基固体的疏水特性，有助于水的扩散，从而抑制了反应中生成的水对酸位点造成的中毒。此外，由于具有较大的介孔，反应物和产物的扩散得以促进，因此催化活性进一步提高。
• Template-free synthesis of porous carbonaceous solid acids with controllable acid sites and their excellent activity for catalyzing the synthesis of biofuels and fine chemicals
  作者：Fujian Liu、Bojie Li、Chen Liu、Weiping Kong、Xianfeng Yi、Anmin Zheng、Chenze Qi

  DOI：10.1039/c5cy01226k

  日期：——

  immobilized acidic groups were homogeneously dispersed into NPC-[CxN][X]. Notably, NPC-[CxN][X] acted as efficient, reusable and generalized solid acids, which showed excellent activity in various acid-catalyzed reactions such as esterification and transesterification in the synthesis of biodiesel, dehydration of fructose into 5-hydroxymethylfurfural, depolymerization of crystalline cellulose into sugars,

  富氮多孔碳基固体酸（NPC- [C x N] [X]）已通过用各种季铵化试剂（如碘甲烷，1,3-丙烷磺内酯和1,4-丁磺酸内酯，以及与各种强酸如HSO离子交换3 CF 3，H 2 SO 4，H 3 PW 12 ø 40，HBF 4等的NPC支持由KOH活化的聚吡咯的合成碳化而不使用其他模板。各种表征表明，NPC- [C xN] [X]具有丰富的纳米孔，大的Brunauer-Emmett-Teller表面积，良好的稳定性以及具有Brønsted特征的强且可控制的酸位。固定的酸性基团均匀分散在NPC- [C x N] [X]中。值得注意的是，NPC- [C xN] [X]可作为有效，可重复使用的通用固体酸，在各种酸催化的反应中表现出出色的活性，例如在生物柴油合成中的酯化和酯交换，果糖脱水成5-羟甲基糠醛，结晶纤维素解聚成糖，以及在双酚A合成中苯酚与丙酮的缩合反应，远高于诸如Amberlyst
• PROCESS FOR THE MANUFACTURE OF POLYPHENOLS
  申请人：Fetsko Stephen W.

  公开号：US20090137848A1

  公开（公告）日：2009-05-28

  An improved process for the manufacture of a polyphenol compound such as bisphenol-A by introducing into a reaction zone a phenolic compound reactant, a carbonyl compound reactant, and a catalyst promoter comprising bismethylthiopropane added to the reaction system in certain specific locations, and reacting the ingredients within the reaction zone in the presence of an acid catalyst.

  一种改进的制造多酚类化合物（如双酚-A）的工艺，通过将酚类反应物、羰基化合物反应物和催化剂促进剂（包括添加到反应系统中的双甲基硫代丙烷）引入反应区域的特定位置，并在酸性催化剂的存在下在反应区域内反应这些成分。

表征谱图