2,5-二氨基甲苯 二盐酸盐

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,5-二氨基甲苯 二盐酸盐
• 中文别名: 2,5-二氨基甲苯二盐酸盐
• 英文名称: hydron;2-methylbenzene-1,4-diamine;dichloride
• 化学式: C7H12Cl2N2
• 分子量: 195.09
• InChiKey: VQUHVWVGRKTIBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.0
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  52
• 氢给体数：
  4
• 氢受体数：
  2

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。 高铁血红蛋白血症 - 血液中高铁血红蛋白含量增加；该化合物被归类为第二毒性效应 皮肤致敏剂 - 可以诱导皮肤过敏反应的剂。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、气囊面罩装置或口袋面罩，按培训操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者向前倾或放在左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗救助。 /有机碱/胺及相关化合物/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有必要，使用口咽或鼻咽气道）。如有必要，进行吸痰。密切观察呼吸不足的迹象，如有必要，进行辅助通气。通过非重复呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克并如有必要进行治疗……。预防癫痫并如有必要进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能够吞咽、有强烈的呕吐反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/有机碱/胺和相关化合物/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于无意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊阀面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿...。监测心率和必要时治疗心律失常...。开始静脉输注D5W /SRP: "保持开放"，最低流量/。如果出现低血容量的迹象，使用0.9%生理盐水（NS）或乳酸钠林格氏液（LR）。对于伴有低血容量迹象的低血压，谨慎给予液体。如果病人对这些措施无反应，血管加压药可能有所帮助。注意观察液体过载的迹象...。如果病人在严重低氧血症、发绀和心脏受损（对氧疗无反应）的情况下出现症状，给予1%亚甲蓝溶液。 ...。用地西泮或劳拉西泮治疗癫痫...。使用丙美卡因氢氯化物协助眼部冲洗...。 /有机碱/胺及相关化合物/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验动物：急性暴露/研究的目的是评估对对苯二胺2HCl（PTD）、对苯二胺（PPD）、对氨基酚（PAP）、对氨基苯（PAB）和苏丹III的皮肤致敏潜力，并研究交叉反应性。诱导是根据豚鼠最大化测试协议，在第0天进行注射，并在第7天进行局部应用，持续48小时。修改包括没有选择可能最高的诱发浓度，并且挑战是通过开放应用而不是封闭应用进行的。在第21天通过开放应用24小时进行挑战。在挑战应用后24、48和72小时进行读数。这里只回顾与PTD相关的结果。用PTD诱导的动物（6/6）在PTD挑战时都有反应，表明测试物质是一种极其强烈的皮肤致敏剂。在用PTD诱导的动物中，也记录了PPD（5/6）、PAP（3/6）、PAB（5/6）和苏丹III（1/6）挑战时的阳性反应，这表明对这些物质存在交叉反应性。用PPD诱导的动物（6/6）在PTD挑战时反应，但用PAP或PAB诱导的动物则没有。结果表明，用PPD诱导的动物对PTD存在交叉反应性。

/LABORATORY ANIMALS: Acute Exposure/ The aim of the study was to evaluate the skin sensitizing potency of p-toluenediamine 2HCl (PTD), p-phenylenediamine (PPD), p-aminophenol (PAP), p-aminobenzene (PAB) and Sudan III, and to study cross-reactivity. Induction was performed according to the guinea pig maximization test protocol by injections on day 0, and topical application on day 7 for 48 hours. Modifications included that the highest possible elicitation concentrations were not chosen, and that challenge was performed by open application and not closed. Challenge on day 21 by open application for 24 hours. Readings were made at 24, 48 and 72 hours after challenge application. Only results related to PTD are reviewed here. 100% of the animals induced with PTD (6/6) reacted at challenge with PTD, showing that the test substance was an extremely potent skin sensitizer. Positive reactions were recorded in the animals induced with PTD at challenge also with PPD (5/6), PAP (3/6), PAB (5/6) and Sudan III (1/6), indicating cross-reactivity to these substances in animals induced with PTD. 100% of the animals induced with PPD (6/6) reacted at challenge with PTD, but not in animals induced with PAP or PAB. The results indicate cross-reactivity to PTD in animals induced with PPD.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

1毫升0.4%水溶液(14)C-甲苯-2,5-二胺盐酸盐（比活性：12.8 mCi/g甲苯-2,5-二胺）对18只Sprague-Dawley大鼠进行了皮下给药。在24小时内，超过65%的放射性物质通过尿液排出。5天后，大约15%的放射性物质在粪便中找到，6.9%在全身匀浆中检测到。

A 1-mL subcutaneous administration of 0.4% aqueous (14)C-toluene-2,5-diamine hydrochloride (specific activity: 12.8 mCi/g toluene-2,5-diamine) was given to 18 Sprague-Dawley rats. More than 65% of the radioactivity was excreted in the urine within 24 hours. After 5 days, approximately 15% of the radioactivity was found in the feces, and 6.9% was detected in the total-body homogenate.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

18只Sprague-Dawley大鼠通过胃管口服了1毫升1.6%的水溶液放射性甲苯-2,5-二胺盐酸盐（比活性，15.8 mCi/g甲苯-2,5-二胺）。在24小时内，超过70%的放射性物质通过尿液排出。5天后，总共有10%在粪便中检测到，1.2%在体匀浆中检测到，1.4%残留在胃肠道中。

Eighteen Sprague-Dawley rats were given 1-mL oral doses of a 1.6% aqueous solution of radioactive toluene-2,5-diamine hydrochloride (specific activity, 15.8 mCi/g toluene-2,5-diamine) by stomach tube. Within 24 hours, more than 70% of the radioactivity was excreted in the urine. After 5 days, a total of 10% was detected in the feces, 1.2% was detected in the body homogenate, and 1.4% remained in the gastrointestinal tract.

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• [EN] TRI-AROMATIC AZOMETHINE DIRECT DYES COMPRISING AT LEAST ONE UNIT DERIVED FROM RESORCINOL, DYEING COMPOSITION, METHOD AND USE<br/>[FR] COLORANTS DIRECTS D'AZOMÉTHINE TRIAROMATIQUES COMPRENANT AU MOINS UNE UNITÉ DÉRIVÉE DE RÉSORCINOL, COMPOSITION DE COLORANT, LEUR PROCÉDÉ ET LEUR UTILISATION
  申请人：OREAL

  公开号：WO2013087772A1

  公开（公告）日：2013-06-20

  The present invention relates to azomethine-type direct dyes with a tri-aromatic unit having the following formula (I) : and their use for colouring keratin fibres, particularly human keratin fibres such as the hair. The invention also relates to a composition for dyeing keratin fibres comprising, in a suitable medium for dyeing, such direct dyes. Another subject of the present invention is a method for dyeing keratin fibres using said dyeing composition. Finally the present invention also relates to precursors for these direct dyes.

  本发明涉及具有以下公式（I）的三芳基单元的偶氮甲基型直接染料，以及它们用于染色角蛋白纤维，特别是人类角蛋白纤维如头发。本发明还涉及一种用于染色角蛋白纤维的组合物，其中包含适用于染色的直接染料和适当的介质。本发明的另一个主题是使用所述染料组合物染色角蛋白纤维的方法。最后，本发明还涉及这些直接染料的前体。
• AZOMETHINE DIRECT DYES OR REDUCED PRECURSORS OF THESE DYES OBTAINED FROM 2-CHLORO-3-AMINO-6-METHYLPHENOL, AND HAIR DYEING METHOD STARTING FROM THESE DYES AND PRECURSORS
  申请人：Leduc Madeleine

  公开号：US20110041261A1

  公开（公告）日：2011-02-24

  The invention relates to the dyeing of keratinous fibres using azomethine direct dyes of formula (I) or reduced precursors of azomethine direct dyes of formula (II) obtained from 2-chloro-3-amino-6-methylphenol. A subject-matter of the invention is a dyeing composition comprising at least one chlorinated azomethine direct dye or one reduced precursor of a chlorinated azomethine direct dye, a method for dyeing keratinous fibres which employs the said composition and their uses in the dyeing of keratinous fibres. This composition makes it possible to obtain a particularly stable and consistent colouring.

  本发明涉及使用公式(I)的偶氮甲基直接染料或公式(II)的还原前体来染色角蛋白纤维。所述偶氮甲基直接染料或其还原前体是由2-氯-3-氨基-6-甲基苯酚制备而成。本发明的一种对象是染料组合物，包括至少一种氯化偶氮甲基直接染料或一种氯化偶氮甲基直接染料的还原前体，以及一种用于染色角蛋白纤维的方法，该方法采用上述组合物，并且该组合物在染色角蛋白纤维时能够获得特别稳定和一致的着色。
• Novel polyester polymers
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0252415A2

  公开（公告）日：1988-01-13

  Polyester polymers consisting essentially of repeating units having the formula repeating units having the formula repeating units having the formula and repeating units having the formula wherein Ar1 is selected from Ar2 is selected from halogen substituted radicals of these radicals, and wherein X is selected from -0-, -S-, -SOr, -CO-, wherein each n independently represents a member having a value of from 1 to 10, and each R4 is independently selected from alkyl radicals of 1 to 5 carbon atoms, and R2 and R3 are independently selected from hydrogen atom, halogen radicals, alkyl radicals of 1 to 5 carbon atoms, and phenyl radical, and R2 and R3 may be identical or different from. each other, and R1 is selected from halogen radicals and alkyl radicals of 1 to 5 carbon atoms, and wherein the polyester polymer has a reduced viscosity [ sp/c] of at least 0.2 dl/g as measured in p-chlorophenol at a concentration of 0.2 g/dl at 60 °C . Such polyester polymers are excellent in the mechanical strength and heat resistance and, therefore, are useful as various kinds of fibers, films, or engineering plastics. A process for preparing the polyester polymer and novel diimide-dicarboxylic acid to be used as a material in this process are also disclosed.

  主要由以下式子的重复单元组成的聚酯聚合物 式的重复单元 式的重复单元 和具有以下式子的重复单元 其中 Ar1 选自 Ar2 选自 这些基的卤素取代基，以及 其中 X 选自-0-、-S-、-SOr、-CO-、 其中每个 n 独立地代表数值为 1 至 10 的成员，每个 R4 独立地选自 1 至 5 个碳原子的烷基，以及 R2 和 R3 独立地选自氢原子、卤素基、1 至 5 个碳原子的烷基和苯基，且 R2 和 R3 可以相同或不同，以及 R1 选自卤素基和 1 至 5 个碳原子的烷基，其中聚酯聚合物的还原粘度[ sp/c] 至少为 0.2 dl/g，该粘度是在对氯苯酚浓度为 0.2 g/dl 时于 60 °C 测得的。 这种聚酯聚合物具有优异的机械强度和耐热性，因此可用作各种纤维、薄膜或工程塑料。此外，还公开了制备聚酯聚合物的工艺和在该工艺中用作材料的新型二亚胺二羧酸。
• IONIC ORGANIC COMPOUND, PRODUCTION METHOD THEREOF, HYDROGELLING AGENT COMPOSED OF THE IONIC ORGANIC COMPOUND, HYDROGEL CONTAINING SAME, METHANOL GELLING AGENT, METHANOL GEL CONTAINING SAME, AND CARBON NANOTUBE DISPERSANT
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP2330143A1

  公开（公告）日：2011-06-08

  Disclosed are a novel ionic organic compound and a method for producing the ionic organic compound by a simple process. Also disclosed are a hydrogelling agent composed of an ionic organic compound obtained by the method, an alcohol gelling agent, a gel which uses the gelling agent, while using water or methanol as a medium, and a carbon nanotube dispersant composed of the compound. Specifically disclosed is an ionic organic compound, represented by general formula (1). The compound is obtained by a condensation reaction of (A) an aromatic diamide compound or cyclohexane diamide compound having a 4-(chloromethyl)benzamide group at both ends, and (B) a compound selected from N,N,N',N'-tetramethylalkylenediamines which may have a substituent wherein there are 1-6 carbon atoms between nitrogen atoms. The thus-obtained ionic organic compound serves as a gelling agent which is capable of gelling a neutral aqueous solution or an alcohol. The solvent solubility can be changed by substituting the anion of the thus-obtained ionic compound with another anion by anion-exchange. (In the formula, A represents a linking moiety having one or more optionally substituted aromatic rings or a linking moiety composed of a cyclohexane ring; B represents a cationic functional group having a quaternized nitrogen atom, which is selected trom N,N,N',N'-tetramethylalkylenediamines which may have a substituent wherein there are 1-6 carbon atoms between nitrogen atoms; X represents a monovalent anion; and n represents an integer of 1-800.)

  本发明公开了一种新型离子有机化合物和一种通过简单工艺生产该离子有机化合物的方法。还公开了由通过该方法获得的离子有机化合物组成的水胶凝剂、醇胶凝剂、使用该胶凝剂同时使用水或甲醇作为介质的凝胶，以及由该化合物组成的碳纳米管分散剂。具体公开了一种离子有机化合物，由通式（1）表示。该化合物是通过以下两种物质的缩合反应得到的：(A)两端具有 4-（氯甲基）苯甲酰胺基团的芳香族二酰胺化合物或环己烷二酰胺化合物；(B)选自 N,N,N',N'-四甲基烷基二胺的化合物，该化合物可具有取代基，其中氮原子之间有 1-6 个碳原子。由此获得的离子有机化合物可用作胶凝剂，能够胶凝中性水溶液或醇。通过阴离子交换法，用另一种阴离子取代由此获得的离子化合物的阴离子，可以改变溶剂的溶解度。(式中，A 代表具有一个或多个任选取代的芳香环的连接基团，或由环己烷环组成的连接基团；B 代表具有季化氮原子的阳离子官能团，该官能团选自 N,N,N',N'-四甲基烷二胺，其中氮原子间可有 1-6 个碳原子的取代基；X 代表一价阴离子；n 代表 1-800 的整数)。
• Fashionable copper shades in a nonionic base
  申请人：Henkel AG & Co. KGaA

  公开号：US10034822B2

  公开（公告）日：2018-07-31

  An agent for oxidatively dyeing keratinous fibers, in particular human hair, includes —in a cosmetic carrier— (A) 1-(2-hydroxyethyl)-4,5-diamino pyrazole and/or a physiologically acceptable salt thereof, (B) 2,6-dihydroxy-3,4-dimethylpyridine, (C) hydrogen peroxide, and (D) one or more nonionic surfactants, wherein the total content of all anionic surfactants (E) included in the agent is below 0.6 wt %, based on the total weight of the agent. A second subject matter of the present invention is a corresponding multicomponent packaging unit (kit-of-parts).

  一种用于氧化染色角质纤维，特别是人类头发的制剂，包括--在化妆品载体中-- 用于氧化染色角质纤维，特别是人类头发的制剂。 (A) 1-(2-羟乙基)-4,5-二氨基吡唑和/或其生理上可接受的盐、 (B) 2,6-二羟基-3,4-二甲基吡啶、 (C) 过氧化氢，以及 (D) 一种或多种非离子表面活性剂、 其中，以制剂总重量为基准，制剂中包含的所有阴离子表面活性剂 (E) 的总含量低于 0.6 wt %。 本发明的第二个主题是相应的多组分包装单元（部件套件）。

表征谱图