2,5-二甲基萘-1-醇 | 175841-32-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2,5-二甲基萘-1-醇
• 英文名称: 1,6-dimethyl-5-hydroxynaphthalene
• 英文别名: 2,5-dimethylnaphthalen-1-ol；2,5-dimethyl-1-naphthol；2,5-dimethyl-α-naphthol；2,5-Dimethyl-naphthol-(1)
• CAS: 175841-32-4
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: WHWZJCKKJVJWBH-UHFFFAOYSA-N

物化性质

• 沸点：
  321.4±11.0 °C(Predicted)
• 密度：
  1.114±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-二甲基萘-1-醇 在 palladium on activated charcoal 氢气 、 乙酸酐 、 sodium hydride 、 copper(II) nitrate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 4-Methoxy-3,8-dimethyl-naphthalen-1-ylamine
  参考文献：
  名称：

  Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity

  摘要：

  Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.039
• 作为产物：
  描述：

  5-甲基-1-萘酚 在 10percent Pd/C 氢气 、 丙酸 、 苯硼酸 作用下， 以 甲醇 、 苯 为溶剂， 反应 6.0h， 生成 2,5-二甲基萘-1-醇
  参考文献：
  名称：

  通过围环闭合轻松构建 oxaphenalene 骨架。曼索酮 F 的形式合成

  摘要：

  通过萘酚醚的易周环闭合有效地构建 oxaphenalene 骨架，以及从容易获得的 5-甲氧基-1-四氢萘酮开始的环化前体的有效制备采用钯诱导的萘酚芳构化。

  DOI：

  10.1039/b001859g

文献信息

• Efficient Synthesis of 1-Thiomansonones with Anti-MRSA Activity
  作者：Dongyun Shin、Seong-Hyuk Park、Sooyoung Park、Chang-Yong Lee、Young-Ger Suh

  DOI：10.1055/s-0036-1591894

  日期：2018.4

  In this study, we developed an efficient and general synthetic strategy for thiaphenalene, a sulfur-containing polyaromatic hetero­cycle, and applied for the synthesis of 1-thio derivatives of mansonone I and F, natural 1-oxaphenalenic orthoquinones. The pivotal steps for the construction of thiophenalene skeleton include formation of arylsulfide by Newman–Kwart rearrangement of thiocarbamate or palladium-­catalyzed cross-coupling, and pericyclic ring closure. Three bioisosterically modified orthoquinones were synthesized and were evaluated for anti-MRSA activity.

  在这项研究中，我们为噻吩并苯，一种含硫的多环芳烃杂环，开发了一种高效且通用的合成策略，并应用于天然1-氧杂苯并苯醌的1-硫代衍生物曼松酮I和F的合成。构建噻吩并苯骨架的关键步骤包括通过Newman-Kwart重排噻吩甲酸盐或钯催化的交叉偶联形成芳基硫化物，以及周环闭环。合成了三种生物等排修饰的邻醌，并对其抗MRSA活性进行了评估。
• Process For Producing Phosphonitrilic Acid Ester
  申请人：Kuwata Kotaro

  公开号：US20080091050A1

  公开（公告）日：2008-04-17

  A process for producing a cyclic and/or linear phosphonitrilic acid ester from a cyclic and/or linear phosphonitrile dichloride is provided, wherein the reaction time is shorter and the content of monochloro phosphazenes is very small. When phosphonitrile dichloride is reacted with a metal arylolate and/or a metal alcoholate in the presence of a reaction solvent, a metal arylolate and/or a metal alcoholate composed of at least two different metals having different ionization energies is used and also a specific compound is used as a catalyst.

  解决的问题：提供一种从环状和/或线性磷酸腈二氯化物制备环状和/或线性磷氮酸酯的方法，其中反应时间较短，单氯磷氮烷的含量非常小。 解决方案：当磷酸腈二氯化物与金属芳酚醇盐和/或金属醇盐在反应溶剂存在下反应时，使用由至少两种具有不同电离能的金属组成的金属芳酚醇盐和/或金属醇盐，并且还使用特定化合物作为催化剂。
• Synthesis of Some Substituted Naphthalenes as Potential Intermediates for Polyethers and Terpenoids
  作者：A. K. Banerjee、P. S. Poon、M. S. Laya、J. A. Azocar

  DOI：10.1023/b:rugc.0000018662.02489.8d

  日期：2003.11

  1-Benzyloxy-5-hydroxynaphthalene and 1,6-dimethyl-5-hydroxynaphthalene were prepared from 5-methoxy-alpha-tetralone. 6-Methoxy-alpha-tetralone was converted to 1,6-dimethoxy-2-isopropylnaphthalene.
• Process for producing phosphonitrilic acid ester
  申请人：Kuwata Kotaro

  公开号：US20070060739A1

  公开（公告）日：2007-03-15

  A process for producing a phosphonitrilic acid ester. The process comprises using a specific compound as a catalyst to react phosphonitrile dichloride with at least one member selected among phenol compounds and/or alcohol compounds in the presence of a reaction solvent. Alternatively, the process comprises reacting a liquid reaction mixture obtained in a first stage with at least one member selected among phenol compounds and/or alcohol compounds without isolating phosphonitrile dichloride from the mixture.
• US3987068A
  申请人：——

  公开号：US3987068A

  公开（公告）日：1976-10-19