2,5-二甲基萘-1-醇 | 175841-32-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2,5-二甲基萘-1-醇
• 英文名称: 1,6-dimethyl-5-hydroxynaphthalene
• 英文别名: 2,5-dimethylnaphthalen-1-ol；2,5-dimethyl-1-naphthol；2,5-dimethyl-α-naphthol；2,5-Dimethyl-naphthol-(1)
• CAS: 175841-32-4
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: WHWZJCKKJVJWBH-UHFFFAOYSA-N

物化性质

• 沸点：
  321.4±11.0 °C(Predicted)
• 密度：
  1.114±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-二甲基萘-1-醇 在 palladium on activated charcoal 氢气 、 乙酸酐 、 sodium hydride 、 copper(II) nitrate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 4-Methoxy-3,8-dimethyl-naphthalen-1-ylamine
  参考文献：
  名称：

  Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity

  摘要：

  Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.039
• 作为产物：
  描述：

  5-甲基-1-萘酚 在 10percent Pd/C 氢气 、 丙酸 、 苯硼酸 作用下， 以 甲醇 、 苯 为溶剂， 反应 6.0h， 生成 2,5-二甲基萘-1-醇
  参考文献：
  名称：

  通过围环闭合轻松构建 oxaphenalene 骨架。曼索酮 F 的形式合成

  摘要：

  通过萘酚醚的易周环闭合有效地构建 oxaphenalene 骨架，以及从容易获得的 5-甲氧基-1-四氢萘酮开始的环化前体的有效制备采用钯诱导的萘酚芳构化。

  DOI：

  10.1039/b001859g

文献信息

• Process For Producing Phosphonitrilic Acid Ester
  申请人：Kuwata Kotaro

  公开号：US20080091050A1

  公开（公告）日：2008-04-17

  A process for producing a cyclic and/or linear phosphonitrilic acid ester from a cyclic and/or linear phosphonitrile dichloride is provided, wherein the reaction time is shorter and the content of monochloro phosphazenes is very small. When phosphonitrile dichloride is reacted with a metal arylolate and/or a metal alcoholate in the presence of a reaction solvent, a metal arylolate and/or a metal alcoholate composed of at least two different metals having different ionization energies is used and also a specific compound is used as a catalyst.

  解决的问题：提供一种从环状和/或线性磷酸腈二氯化物制备环状和/或线性磷氮酸酯的方法，其中反应时间较短，单氯磷氮烷的含量非常小。 解决方案：当磷酸腈二氯化物与金属芳酚醇盐和/或金属醇盐在反应溶剂存在下反应时，使用由至少两种具有不同电离能的金属组成的金属芳酚醇盐和/或金属醇盐，并且还使用特定化合物作为催化剂。
• Facile construction of the oxaphenalene skeleton by peri ring closure. Formal synthesis of mansonone F
  作者：Young-Ger Suh、Dong-Yun Shin、Kyung-Hoon Min、Soon-Sil Hyun、Jae-Kyung Jung、Seung-Yong Seo

  DOI：10.1039/b001859g

  日期：——

  A concise and divergent total synthesis of mansonone F has been accomplished via an efficient construction of the oxaphenalene skeleton by facile peri ring closure of the naphthol ether, and an effective preparation of the cyclization precursor starting from readily available 5-methoxy-1-tetralone by employing a palladium-induced aromatization of the naphthalinol.

  通过萘酚醚的易周环闭合有效地构建 oxaphenalene 骨架，以及从容易获得的 5-甲氧基-1-四氢萘酮开始的环化前体的有效制备采用钯诱导的萘酚芳构化。
• Synthesis of Some Substituted Naphthalenes as Potential Intermediates for Polyethers and Terpenoids
  作者：A. K. Banerjee、P. S. Poon、M. S. Laya、J. A. Azocar

  DOI：10.1023/b:rugc.0000018662.02489.8d

  日期：2003.11

  1-Benzyloxy-5-hydroxynaphthalene and 1,6-dimethyl-5-hydroxynaphthalene were prepared from 5-methoxy-alpha-tetralone. 6-Methoxy-alpha-tetralone was converted to 1,6-dimethoxy-2-isopropylnaphthalene.
• Process for producing phosphonitrilic acid ester
  申请人：Kuwata Kotaro

  公开号：US20070060739A1

  公开（公告）日：2007-03-15

  A process for producing a phosphonitrilic acid ester. The process comprises using a specific compound as a catalyst to react phosphonitrile dichloride with at least one member selected among phenol compounds and/or alcohol compounds in the presence of a reaction solvent. Alternatively, the process comprises reacting a liquid reaction mixture obtained in a first stage with at least one member selected among phenol compounds and/or alcohol compounds without isolating phosphonitrile dichloride from the mixture.
• US3987068A
  申请人：——

  公开号：US3987068A

  公开（公告）日：1976-10-19