2,6-二[(4R,5R)-4-甲基-5-苯基-2-二恶唑啉]吡啶 | 312624-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-二[(4R,5R)-4-甲基-5-苯基-2-二恶唑啉]吡啶
• 中文别名: 2,6-双[(4R,5R)-4-甲基-5-苯基-2-噁唑啉基]吡啶
• 英文名称: 2,6-bis[(4R,5R)-4,5-dihydro-4-methyl-5-phenyl-2-oxazolyl]pyridine
• 英文别名: 2,6-Bis[(4R,5R)-4-methyl-5-phenyl-2-oxazolinyl]pyridine；(4R,5R)-4-methyl-2-[6-[(4R,5R)-4-methyl-5-phenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridin-2-yl]-5-phenyl-4,5-dihydro-1,3-oxazole
• CAS: 312624-05-8
• 化学式: C₂₅H₂₃N₃O₂
• 分子量: 397.477
• InChiKey: WAQJMWVRZVOTCH-AFXFGAOOSA-N

物化性质

• 熔点：
  135-139 °C(lit.)
• 沸点：
  600.6±55.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)
• 稳定性/保质期：

  在常温常压下稳定，应避免与强氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  56.1
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2934999090
• WGK Germany：
  3

文献信息

• 2'-HYDROXYL-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND MANUFACTURING METHOD OF SAME
  申请人：Kaneka Corporation

  公开号：EP2258709A1

  公开（公告）日：2010-12-08

  The present invention relates to a method for producing a 2'-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2'-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2',3'-hydroxy groups are not protected.

  本发明涉及一种通过在铜化合物和光学活性配体组成的金属配合物存在下，将核糖核苷与酰化试剂反应以制备2'-羟基保护核苷衍生物的方法。根据本发明的方法，可以从未保护2'、3'-羟基的核苷衍生物中轻松、有良好的区域选择性地制备重要的2'-羟基保护核糖核苷衍生物，该衍生物是合成寡核苷酸的重要中间体。
• 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF
  申请人：Maeda Hirofumi

  公开号：US20110009609A1

  公开（公告）日：2011-01-13

  The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected.

  本发明涉及一种通过在存在铜化合物和光学活性配体组成的金属配合物的条件下，将核苷与酰化试剂反应，制备2'-羟基保护核苷衍生物的方法。根据本发明的方法，可以从未保护2'、3'-羟基的核苷衍生物中，以良好的区域选择性轻松地制备出2'-羟基保护的核苷衍生物，该衍生物是合成寡核苷酸的重要中间体。
• Chromium Pyridine Bis(Oxazoline) And Related Catalysts For Ethylene Dimerization
  申请人：Ackerman Lily J.

  公开号：US20080182951A1

  公开（公告）日：2008-07-31

  The present invention provides a method of producing oligomers of olefins, comprising reacting olefins with a chromium based catalyst under oligomerization conditions. The catalyst can be the product of the combination of a chromium compound and a pyridyl bis(oxazoline) or pyridyl bis(thiazoline) ligand. In particular embodiments, the catalyst composition can be used to dimerize ethylene to butenes.
• US8252919B2
  申请人：——

  公开号：US8252919B2

  公开（公告）日：2012-08-28