2,6-二乙苯肼 | 84828-07-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,6-二乙苯肼
• 中文别名: (2,6-二乙基苯基)-肼
• 英文名称: 2,6-Diethyl-phenyl-hydrazin
• 英文别名: 2,6-diethylphenylhydrazine；(2,6-Diethylphenyl)hydrazine
• CAS: 84828-07-9
• 化学式: C₁₀H₁₆N₂
• mdl: MFCD02663065
• 分子量: 164.25
• InChiKey: CKQVIJPMZIQDSK-UHFFFAOYSA-N

物化性质

• 沸点：
  259.8±29.0 °C(Predicted)
• 密度：
  1.015±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  2,6-二乙苯肼 在 氢氧化钾 、 ammonium hydroxide 作用下， 反应 28.0h， 生成 N-[[benzylsulfanyl(1,2,4-triazol-1-ylmethylsulfanyl)methylidene]amino]-2,6-diethylaniline
  参考文献：
  名称：

  Syntheses Starting from 2,6-Dialkylphenylhydrazines

  摘要：

  1,4-二取代半胱氨酸酰胺 I，二硫代卡巴酯 II，III 和 N-(2,6-二烷基苯胺基)咪唑硫代碳酸酯酯 IV，V 是由2,6-二烷基苯基肼制备的。 产品经过农药活性测试。

  DOI：

  10.1135/cccc19921699

文献信息

• 5-Aryl-2-furancarbaldehyde Hydrazones and Related Compounds
  作者：Alžbeta Krutošíková、Miloslava Dandárová、Juraj Alföldi

  DOI：10.1135/cccc19931905

  日期：——

  A series of 5-aryl-2-furancarbaldehyde 2,6-dialkylphenylhydrazones (Ia - Iv) and dimethylhydrazones (IIa - IIf) as well as related compound benzo[b]furan-2-carbaldehyde dimethylhydrazone (III) were prepared. Compounds Ia - Iv were synthesized by condensing 5-aryl-2-furancarbaldehydes with 2,6-dialkylphenylhydrazines, compounds IIa - IIf were obtained from the same starting compounds and N,N-dimethylhydrazine. The intermediate 5-aryl-2-furancarbaldehydes were prepared by reaction of aryldiazonium chlorides with 2-furancarbaldehyde. The structure of the compounds were proven by ¹H, ¹³C and ¹⁵N NMR spectra.

  一系列5-芳基-2-呋喃甲醛2,6-二烷基苯基腙（Ia - Iv）和二甲基腙（IIa - IIf）以及相关化合物苯并[b]呋喃-2-甲醛二甲基腙（III）已经制备。化合物Ia - Iv通过5-芳基-2-呋喃甲醛与2,6-二烷基苯基腙缩合合成，化合物IIa - IIf则来自相同起始化合物和N,N-二甲基腙。中间体5-芳基-2-呋喃甲醛通过芳基重氮氯化物与2-呋喃甲醛反应制备。这些化合物的结构通过1H、13C和15N核磁共振谱得到证实。
• Cooperative <i>N</i>-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenolates
  作者：Benoit Cardinal-David、Dustin E. A. Raup、Karl A. Scheidt

  DOI：10.1021/ja910666n

  日期：2010.4.21

  A new approach that takes advantage of N-heterocyclic carbene/Lewis acid cooperative catalysis provides access to cis-1,3,4-trisubstituted cyclopentenes from enals and chalcone derivatives with high levels of diastereoselectivity and enantioselectivity. The presence of Ti(OiPr)(4) as the Lewis acid allows for efficient substrate preorganization, which translates into high levels of diastereoselectivity

  一种利用 N-杂环卡宾/路易斯酸协同催化的新方法可以从具有高水平非对映选择性和对映选择性的烯醛和查尔酮衍生物中获得顺式 1,3,4-三取代的环戊烯。Ti(OiPr)(4) 作为路易斯酸的存在允许有效的底物预组织，这转化为高水平的非对映选择性。此外，我们证明了通过使用催化量的手性路易斯酸作为光学活性促进剂的独特来源来控制 NHC 催化反应的绝对立体化学的可能性。
• Synthesis and Reactions of Furo[3,2-b]pyrrole Type Aldehydes
  作者：Alžbeta Krutošíková、Miloslava Dandárová、Juraj Alföldi

  DOI：10.1135/cccc19932139

  日期：——

  The synthesis of ethyl 2-formyl-4-benzylfuro[3,2-b]pyrrole-5-carboxylate (I) is described. A series of furo[3,2-b]pyrrole-2-carbaldehyde 2,6-dialkylphenylhydrazones (IIa - IIg) and dimethylhydrazones (IIIa - IIId) were prepared. By reaction of title compounds with hydroxylammonium chloride in acetic anhydride in the presence of pyridine corresponding cyano-substituted compounds (IVa - IVd) were obtained. Alkaline hydrolysis of IVa - IVd gave Va - Vb and the reaction with sodium azide and ammonium chloride in dimethylformamide led to VIa - VId. the structure of the compounds have been proved by UV, IR, ¹H and ¹³C NMR spectra.

  描述了乙酸2-甲酰基-4-苄基呋喃[3,2-b]吡咯-5-羧酸乙酯（I）的合成。制备了一系列呋喃[3,2-b]吡咯-2-甲醛2,6-二烷基苯肼酮（IIa - IIg）和二甲基肼酮（IIIa - IIId）。通过将标题化合物与乙酸酐中的羟胺盐和吡啶反应，在生成的氰基取代化合物（IVa - IVd）中。对IVa - IVd进行碱性水解得到Va - Vb，并在二甲基甲酰胺中与叠氮化钠和氯化铵反应得到VIa - VId。这些化合物的结构已通过UV、IR、1H和13C NMR谱证明。
• CRTH2 Receptor Ligands For Medicinal Uses
  申请人：Ulven Trond

  公开号：US20090099189A1

  公开（公告）日：2009-04-16

  Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic rhinobronchitis, wherein A represents a carboxyl group —COON, or a carboxyl bioisostere; A 1 , is hydrogen or methyl; ring Ar 1 is an optionally substituted phenyl ring 5- or 6-membered monocyclic heteroaryl ring, in which AA 1 CHO— and L2 are linked to adjacent ring atoms; rings Are 2 , Ar 3 each independently represent a phenyl or 5- or 6-membered monocyclic heteroaryl ring, or a bicyclic ring system consisting of a 5- or 6-membered carbocyclic or heterocyclic ring which is benz-fused or fused to a 5- or 6-membered monocyclic heteroaryl ring, said ring or ring system being optionally substituted; t is 0 or 1; L2 and L3 are linker radicals as defined in the description.

  式(I)的化合物可用于治疗对CRTH2受体活性调节敏感的疾病，例如哮喘、鼻炎、过敏性气道综合症和过敏性鼻支气管炎，其中A代表羧基—COON或羧基生物同位素；A1为氢或甲基；环Ar1是一个可选取代的苯环5-或6-成员的单环杂环，其中AA1CHO—和L2与相邻的环原子连接；环Are2，Ar3各自独立地表示一个苯环或5-或6-成员的单环杂环，或由一个5-或6-成员的碳环或杂环组成的双环系统，该环或环系统被苯并或与一个5-或6-成员的单环杂环融合，该环或环系统是可选取代的；t为0或1；L2和L3是如描述中所定义的连接基团。
• CRTH2 receptor ligands for medicinal uses
  申请人：Ulven Trond

  公开号：US20110269763A1

  公开（公告）日：2011-11-03

  Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic rhinobronchitis: wherein A represents a carboxyl group —COOH, or a carboxyl bioisostere; A 1 is hydrogen or methyl; ring Ar 1 is an optionally substituted phenyl ring or 5- or 6-membered monocyclic heteroaryl ring, in which AA 1 CHO— and L2 are linked to adjacent ring atoms; rings Ar 2 , Ar 3 each independently represent a phenyl or 5- or 6-membered monocyclic heteroaryl ring, or a bicyclic ring system consisting of a 5- or 6-membered carbocyclic or heterocyclic ring which is benz-fused or fused to a 5- or 6-membered monocyclic heteroaryl ring, said ring or ring system being optionally substituted; t is 0 or 1; L2 and L3 are linker radicals as defined in the description.

  式(I)的化合物可用于治疗对CRTH2受体活性调节敏感的疾病，例如哮喘、鼻炎、过敏性气道综合症和过敏性鼻支气管炎：其中A代表羧基—COOH或羧基生物同位素；A1为氢或甲基；环Ar1为可选取代的苯环或5-或6-成员的单环杂环，其中AA1CHO—和L2连接到相邻的环原子上；环Ar2、Ar3各自独立地表示苯环或5-或6-成员的单环杂环，或由5-或6-成员的碳环或杂环组成的双环系统，该环或环系统是苯并或与5-或6-成员的单环杂环融合，该环或环系统是可选的取代；t为0或1；L2和L3是如描述中定义的连接基。