2,6-二甲基苯甲脒 | 184778-43-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,6-二甲基苯甲脒
• 英文名称: 2,6-Dimethyl-benzamidine
• 英文别名: 2,6-dimethylbenzenecarboximidamide
• CAS: 184778-43-6
• 化学式: C₉H₁₂N₂
• 分子量: 148.2
• InChiKey: RRIKJEBDBLNLOW-UHFFFAOYSA-N

物化性质

• 沸点：
  253.2±50.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.9
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR<br/>[FR] MODULATEURS DU RÉGULATEUR DE LA CONDUCTANCE TRANSMEMBRANAIRE DE LA MUCOVISCIDOSE
  申请人：VERTEX PHARMA

  公开号：WO2022076627A1

  公开（公告）日：2022-04-14

  This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure:, pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies and combination pharmaceuticals employing those modulators, and processes and intermediates for making such modulators.

  本公开提供囊性纤维化跨膜传导调节因子（CFTR）的调节剂，其具有以下核心结构：，包含至少一种这样的调节剂的药物组合物，使用这样的调节剂和药物组合物治疗CFTR介导的疾病，包括囊性纤维化的方法，使用这些调节剂的组合疗法和组合药物，以及制造这些调节剂的过程和中间体。
• AMINOPYRIDINES AND AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Jimenez Juan-Miguel

  公开号：US20100022502A1

  公开（公告）日：2010-01-28

  The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及用作蛋白激酶抑制剂的化合物。本发明还提供了包括所述化合物的药学上可接受的组合物，并提供了使用这些组合物治疗各种疾病、状况或障碍的方法。本发明还提供了制备本发明化合物的方法。
• Process for Preparing 5-Fluoro-1H-Pyrazolo [3,4-b] Pyridin-3-amine and Derivatives Thereof
  申请人：Jimenez Juan-Miguel

  公开号：US20100184980A1

  公开（公告）日：2010-07-22

  The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.

  本发明涉及一种高产率和纯度的合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。本发明还涉及合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的方法。这些方法可用于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。
• PROCESS FOR PREPARING 5-FLUORO-1H-PYRAZOLO [3,4-B] PYRIDIN-3-AMINE AND DERIVATIVES THEREOF
  申请人：Jimenez Juan-Miguel

  公开号：US20120232275A1

  公开（公告）日：2012-09-13

  The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.

  本发明涉及一种高收率和高纯度合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。本发明还涉及合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的方法。这些方法有助于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。
• ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
  申请人：UNIVERSAL DISPLAY CORPORATION

  公开号：US20220259242A1

  公开（公告）日：2022-08-18

  Provided are compounds of formula M(L 1 )(L 2 ), wherein M is Pd or Pt; L 1 is a tridentate ligand, or a substituted or unsubstituted cyclopentadienyl ligand; L 2 is a bidentate ligand; if L 1 is a tridentate ligand, then it is coordinated to M forming at least two 6-membered chelate rings; if L 1 is a cyclopentadienyl ligand, then L 2 is a monoanionic ligand; and L 1 and L 2 can be joined together by a linker. Also provided are formulations comprising these compounds. Further provided are OLEDs and related consumer products that utilize these compounds.